Maximilian Seidl
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View article: Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer
Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer Open
The aggressiveness of prostate cancer is primarily assessed from histopathological data using the Gleason scoring system. Conventional artificial intelligence (AI) approaches can predict Gleason scores, but often lack explainability, which…
View article: 2D-3D deformable image registration of histology slide and micro-CT with DISA-based initialization
2D-3D deformable image registration of histology slide and micro-CT with DISA-based initialization Open
View article: Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children
Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children Open
Objectives Infections with non-tuberculous mycobacteria (NTM) in children usually affect the lymph nodes and surrounding tissue. Although the infection is typically self-limiting, it carries a substantial risk of complications due to persi…
View article: Immune training enhances anti-viral responses and improves outcomes in Pax5−/+ mice susceptible to chronic infection
Immune training enhances anti-viral responses and improves outcomes in Pax5−/+ mice susceptible to chronic infection Open
View article: Ectopic Corticotropin-Releasing Hormone/Adrenocorticotropic Hormone-Co-Secreting Neuroendocrine Tumors Leading to Cushing’s Disease: A Case Presentation and Literature Review
Ectopic Corticotropin-Releasing Hormone/Adrenocorticotropic Hormone-Co-Secreting Neuroendocrine Tumors Leading to Cushing’s Disease: A Case Presentation and Literature Review Open
Background: Adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) are essential regulators of cortisol production within the hypothalamic-pituitary-adrenal (HPA) axis. Elevated cortisol levels, resulting from excessi…
View article: SOCS1 deficiency—crossroads of autoimmunity and autoinflammation—two case reports
SOCS1 deficiency—crossroads of autoimmunity and autoinflammation—two case reports Open
Suppressors of cytokine signaling (SOCS) proteins play a critical role in regulating immune signaling pathways. Deficiency of SOCS1 leads to various autoimmune pathologies. We present two unrelated patients with distinct clinical manifesta…
View article: Editorial: Tumor-draining lymph nodes
Editorial: Tumor-draining lymph nodes Open
View article: High interobserver variability of PTEN immunohistochemistry defining PTEN status in low- to intermediate-risk prostate cancer: results of the first German ring trial
High interobserver variability of PTEN immunohistochemistry defining PTEN status in low- to intermediate-risk prostate cancer: results of the first German ring trial Open
View article: ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA
ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA Open
Although adenosine deaminase 2 (ADA2) is considered an extracellular ADA, evidence questions the physiological relevance of this activity. Our study reveals that ADA2 localizes within the lysosomes, where it is targeted through modificatio…
View article: Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer
Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer Open
The aggressiveness of prostate cancer, the most common cancer in men worldwide, is primarily assessed based on histopathological data using the Gleason scoring system. While artificial intelligence (AI) has shown promise in accurately pred…
View article: 2D-3D Deformable Image Registration of Histology Slide and Micro-CT with ML-based Initialization
2D-3D Deformable Image Registration of Histology Slide and Micro-CT with ML-based Initialization Open
Recent developments in the registration of histology and micro-computed tomography (μCT) have broadened the perspective of pathological applications such as virtual histology based on μCT. This topic remains challenging because of the low …
View article: Resorbable Patient-Specific Implants of Molybdenum for Pediatric Craniofacial Surgery—Proof of Concept in an In Vivo Pilot Study
Resorbable Patient-Specific Implants of Molybdenum for Pediatric Craniofacial Surgery—Proof of Concept in an In Vivo Pilot Study Open
Titanium continues to be the gold standard in the field of osteosynthesis materials. This also applies to pediatric craniofacial surgery. Various resorbable materials have already been developed in order to avoid costly and risky second op…
View article: The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification
The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification Open
View article: Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis
Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis Open
Background Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephrit…
View article: Comparative analysis of diagnostic ultrasound and histopathology for detecting cervical lymph node metastases in head and neck cancer
Comparative analysis of diagnostic ultrasound and histopathology for detecting cervical lymph node metastases in head and neck cancer Open
Purpose We evaluated the current performance of diagnostic ultrasound (US) for detecting cervical lymph node (LN) metastases based on objective measures and subjective findings in comparison to the gold standard, histopathological evaluati…
View article: How Does the Biocompatibility of Molybdenum Compare to the Gold Standard Titanium?—An In Vivo Rat Model
How Does the Biocompatibility of Molybdenum Compare to the Gold Standard Titanium?—An In Vivo Rat Model Open
Molybdenum is an essential trace element, considered in recent work to be a promising 3D-printable biodegradable material for medical applications. Specifically, in our recent in vitro work, we were able to show that molybdenum is a materi…
View article: Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency–Associated Villous Atrophy and Norovirus Infection
Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency–Associated Villous Atrophy and Norovirus Infection Open
View article: Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency
Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency Open
Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific antibody responses, comprises a heterogeneous patient population in terms of clinic…
View article: Acute corneal melt and perforation – A possible complication after riboflavin/UV-A crosslinking (CXL) in keratoconus
Acute corneal melt and perforation – A possible complication after riboflavin/UV-A crosslinking (CXL) in keratoconus Open
View article: Update zur kooperativen autopsiebasierten Forschung in der deutschen Pathologie, Neuropathologie und Gerichtsmedizin
Update zur kooperativen autopsiebasierten Forschung in der deutschen Pathologie, Neuropathologie und Gerichtsmedizin Open
View article: High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study
High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study Open
View article: Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report
Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report Open
Background In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial to prevent device-associated…
View article: First report from the German COVID-19 autopsy registry
First report from the German COVID-19 autopsy registry Open
View article: Multiple Immunostainings with Different Epitope Retrievals—The FOLGAS Protocol
Multiple Immunostainings with Different Epitope Retrievals—The FOLGAS Protocol Open
We describe a sequential multistaining protocol for immunohistochemistry, immunofluorescence and CyTOF imaging for formalin-fixed, paraffin-embedded specimens (FFPE) in the formalin gas-phase (FOLGAS), enabling sequential multistaining, in…
View article: High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study
High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study Open
Background The rate of SARS-CoV-2 breakthrough infections in vaccinees is becoming an increasingly serious issue. Objective To determine the causes of death, histological organ alteration, and viral spread in relation to demographic, clini…
View article: Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms
Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms Open
A link between high sodium chloride (salt) intake and the development of autoimmune diseases was previously reported. These earlier studies demonstrated exacerbation of experimental autoimmune encephalomyelitis and colitis by excess salt i…
View article: Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity
Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity Open
View article: Secondary sclerosing cholangitis as a complication of severe COVID‐19: A case report and review of the literature
Secondary sclerosing cholangitis as a complication of severe COVID‐19: A case report and review of the literature Open
This case of secondary sclerosing cholangitis (SSC‐CIP) emphasizes the need to provide follow‐up care for patients that have recovered from COVID‐19 in order to understand the complexity of SARS‐CoV‐2 associated sequela.
View article: Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation
Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation Open
Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. However, the strength of alloreactivity is biased by non-immunological factors such as ischemia reperfusion injury (IRI). Accordingly, …
View article: Pulmonary granulomatosis of genetic origin
Pulmonary granulomatosis of genetic origin Open
Granulomatous inflammation of the lung can be a manifestation of different conditions and can be caused by endogenous inflammation or external triggers. A multitude of different genetic mutations can either predispose patients to infection…