Maximiliano L. Cacicedo

Incorporation of monophosphoryl lipid A and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations Open

Alejandro Vaquero, Paula Calderón-Ruiz, Rocío Celeste Gambaro, Ignacio Rivero-Berti, M. A. Limeres , et al. · 2025

Lipid nanoparticles (LNPs) were engineered for efficient mRNA delivery and immune enhancement through co-encapsulation of adjuvants. CpG-oligodeoxynucleotides (CpG-ODN, TLR9 agonist) and monophosphoryl lipid A (MPLA, TLR4 agonist) were inc…

mRNA-LNP vaccines against hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models Open

María J. Limeres, Rocío Celeste Gambaro, Malin Svensson, Silvia Fraude-El Ghazi, Leah Pretsch , et al. · 2025

Over 300 million people worldwide suffer from chronic hepatitis B virus (HBV) infections that can cause serious liver damage and hepatocellular carcinoma. Ineffective innate and adaptive immune responses characterize these chronic infectio…

mRNA-LNP vaccines against Hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models Open

María J. Limeres, Rocío Celeste Gambaro, Malin Svensson, Silvia Fraude-El Ghazi, Leah Pretsch , et al. · 2025

Over 300 million people worldwide suffer from chronic hepatitis B virus infections that can cause serious liver damage and hepatocellular carcinoma. Ineffective innate and adaptive immune responses characterize these chronic infections, ma…

mRNA-LNP vaccine strategies: Effects of adjuvants on non-parenchymal liver cells and tolerance Open

Malin Svensson, María J. Limeres, Yanira Zeyn, Rocío Celeste Gambaro, Germán A. Islan , et al. · 2025

Encapsulation of Dexamethasone into mRNA–Lipid Nanoparticles Is a Promising Approach for the Development of Liver-Targeted Anti-Inflammatory Therapies Open

Ignacio Rivero Berti, Rocío Celeste Gambaro, María J. Limeres, Cristián Huck‐Iriart, Malin Svensson , et al. · 2024

The objective of this study was to develop two lipid nanoparticle (LNP) formulations capable of efficiently expressing a reporter mRNA while co-delivering the anti-inflammatory drug dexamethasone (DX) to reduce inflammatory side effects in…

Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy Open

Rocío Celeste Gambaro, Ignacio Rivero Berti, María J. Limeres, Cristián Huck‐Iriart, Malin Svensson , et al. · 2024

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/AL…

Liver Cell Type-Specific Targeting by Nanoformulations for Therapeutic Applications Open

Leonard Kaps, María J. Limeres, Paul M. Schneider, Malin Svensson, Yanira Zeyn , et al. · 2023

Hepatocytes exert pivotal roles in metabolism, protein synthesis and detoxification. Non-parenchymal liver cells (NPCs), largely comprising macrophages, dendritic cells, hepatic stellate cells and liver sinusoidal cells (LSECs), serve to i…

mRNA-Based Approaches to Treating Liver Diseases Open

Maximiliano L. Cacicedo, María J. Limeres, Stephan Gehring · 2022

Diseases that affect the liver account for approximately 2 million deaths worldwide each year. The increasing prevalence of these diseases and the limited efficacy of current treatments are expected to stimulate substantial growth in the g…

Modification of Regulatory T Cell Epitopes Promotes Effector T Cell Responses to Aspartyl/Asparaginyl β-Hydroxylase Open

Sebastian Wirsching, Michael Fichter, Maximiliano L. Cacicedo, Katharina Landfester, Stephan Gehring · 2022

Cancer is a leading cause of death worldwide. The search for innovative therapeutic approaches is a principal focus of medical research. Vaccine strategies targeting a number of tumor-associated antigens are currently being evaluated. To d…

CCDC 2088138: Experimental Crystal Structure Determination Open

Facundo Tarasi, Priscila A. Lanza, V. Ferretti, Gustavo A. Echeverría, Oscar E. Piro , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice Open

Maximiliano L. Cacicedo, Christine Weinl-Tenbruck, Daniel Frank, María J. Limeres, Sebastian Wirsching , et al. · 2022

Phenylketonuria (PKU) is an inborn error of metabolism caused by a deficiency in functional phenylalanine hydroxylase (PAH), resulting in accumulation of phenylalanine (Phe) in patients’ blood and organs. Affected patients encounter severe…

OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells Open

Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Leah Pretsch, Michael Fichter , et al. · 2022

Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases. Currently approved n…

Nanostructured Lipid Carriers Loaded with Dexamethasone Prevent Inflammatory Responses in Primary Non-Parenchymal Liver Cells Open

Carolina Medina‐Montano, Ignacio Rivero Berti, Rocío Celeste Gambaro, María J. Limeres, Malin Svensson , et al. · 2022

Liver inflammation represents a major clinical problem in a wide range of pathologies. Among the strategies to prevent liver failure, dexamethasone (DXM) has been widely used to suppress inflammatory responses. The use of nanocarriers for …

mRNA-based therapy proves superior to the standard of care for treating hereditary tyrosinemia 1 in a mouse model Open

Maximiliano L. Cacicedo, Christine Weinl-Tenbruck, Daniel Frank, Sebastian Wirsching, Beate K. Straub , et al. · 2022

Hereditary tyrosinemia type 1 is an inborn error of amino acid metabolism characterized by deficiency of fumarylacetoacetate hydrolase (FAH). Only limited treatment options (e.g., oral nitisinone) are available. Patients must adhere to a s…

Enrichment Methods for Murine Liver Non-Parenchymal Cells Differentially Affect Their Immunophenotype and Responsiveness towards Stimulation Open

Carolina Medina‐Montano, Maximiliano L. Cacicedo, Malin Svensson, María J. Limeres, Yanira Zeyn , et al. · 2022

Hepatocytes comprise the majority of the liver and largely exert metabolic functions, whereas non-parenchymal cells (NPCs)—comprising Kupffer cells, dendritic cells and liver sinusoidal endothelial cells—control the immunological state wit…

Synthesis and Characterization of Novel Copper(II)-Sunitinib Complex: Molecular Docking, DFT Studies, Hirshfeld Analysis and Cytotoxicity Studies Open

Facundo Tarasi, Priscila A. Lanza, Valeria Ferretti, Gustavo A. Echeverría, Oscar E. Piro , et al. · 2021

The main goal of this work was to report the synthesis, characterization, and cytotoxicity study of a novel copper(II)-sunitinib complex, CuSun. It has been synthesized and characterized in solid state and in solution by different methods …

WS12.2 Evolution of inflammatory parameters during CFTR-modulator therapy with lumacaftor/ivacaftor in children aged 6 to 12 years Open

Jochen Rößler, Rebecca L. Knoll, S. Wirsching, Maximiliano L. Cacicedo, Peter Mildenberger , et al. · 2021

Role of Liver-Mediated Tolerance in Nanoparticle-Based Tumor Therapy Open

Maximiliano L. Cacicedo, Carolina Medina‐Montano, Leonard Kaps, Cinja Kappel, Stephan Gehring , et al. · 2020

In the last decades, the use of nanocarriers for immunotherapeutic purposes has gained a lot of attention, especially in the field of tumor therapy. However, most types of nanocarriers accumulate strongly in the liver after systemic applic…

Lipid nanoparticles – Metvan: revealing a novel way to deliver a vanadium compound to bone cancer cells Open

Maximiliano L. Cacicedo, María C. Ruiz, Sebastián Scioli Montoto, María Esperanza Ruiz, Mariela A. Fernández , et al. · 2019

A new Metvan-NLC compound was developed to improve Metvan's biopharmaceutical profile and antitumor efficacy.

Self-Assembly Stereo-Specific Synthesis of Silver Phosphate Microparticles on Bacterial Cellulose Membrane Surface For Antimicrobial Applications Open

Bernardo Bayón, Maximiliano L. Cacicedo, Vera A. Álvarez, Guillermo R. Castro · 2018

New insights into bacterial cellulose materials: production and modification strategies Open

Manuel Horue, Maximiliano L. Cacicedo, Guillermo R. Castro · 2018

Komagataeibacter xylinus cultures produced high amount of bacterial cellulose (BC), which has a structure of nanoporous network of interlaced fibers. When the culture is performed under static experimental conditions, a membrane with chara…

Development and Tailoring of Hybrid Lipid Nanocarriers Open

Germán A. Islan, Maximiliano L. Cacicedo, Boris Rodenak‐Kladniew, Nélson Durán, Guillermo R. Castro · 2018

A new generation of hybrid lipid nanoparticles has emerged by combining the lipidic properties with polymers, proteins and metallic structures. The main features of hybrid lipid nanoparticles including popular methods for synthesis and cha…

Hybrid bacterial cellulose–pectin films for delivery of bioactive molecules Open

Maximiliano L. Cacicedo, Germán A. Islan, M. Florencia Drachemberg, Vera A. Álvarez, Laura C. Bartel , et al. · 2018

Novel biopolymeric films based on bacterial cellulose (BC) modified with high methoxylated pectin (HMP) were developed for drug delivery.

Drug Delivery Systems for Infectious Diseases Open

Maximiliano L. Cacicedo, Germán A. Islan, Pablo Gurman, Guillermo R. Castro · 2017

This chapter describes new advances in the therapeutic procedures for infectious diseases associated to lungs as the primary organ target are covered, including the use of nanotechnology. Microparticles were developed as inhalable carriers…

Desarrollo de sistemas de liberación controlada de agentes quimioterapéuticos en matrices de celulosa microbiana con aplicaciones biomédicas Open

Maximiliano L. Cacicedo · 2017

En el presente trabajo de Tesis se han logrado desarrollar diversos tipos de matrices poliméricas utilizando estructuras basadas en celulosa bacteriana. Luego de comprender los procesos de producción y purificación de la celulosa se proced…

Nanopharmaceuticals as a solution to neglected diseases: Is it possible? Open

Germán A. Islan, Marcela Durán, Maximiliano L. Cacicedo, Gerson Nakazato, Renata Katsuko Takayama Kobayashi , et al. · 2017

Progress in bacterial cellulose matrices for biotechnological applications Open

Maximiliano L. Cacicedo, M. Cristina Castro, Ioannis Servetas, Loulouda Bosnea, Konstantina Boura , et al. · 2016

Modified bacterial cellulose scaffolds for localized doxorubicin release in human colorectal HT-29 cells Open

Maximiliano L. Cacicedo, Ignácio E. León, Jimena S. González, Luismar Marques Porto, Vera A. Álvarez , et al. · 2016

Self-assembly of carrageenin-CaCO<sub>3</sub> hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery Open

Maximiliano L. Cacicedo, Karina Cesca, Valeria E. Bosio, Luismar Marques Porto, Guillermo R. Castro · 2015

Stereospecific nucleation of mesoporous hybrid microspheres composed of CaCO 3 and carrageenan was appended to one side of bacterial cellulose membrane synthesized in static cultures of Gluconacetobacter hansenii to develop an implantable …

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