Maxwell A. Bertolero
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View article: Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain
Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain Open
Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain…
View article: Personalized functional brain network topography is associated with individual differences in youth cognition
Personalized functional brain network topography is associated with individual differences in youth cognition Open
View article: Macroscopic resting-state brain dynamics are best described by linear models
Macroscopic resting-state brain dynamics are best described by linear models Open
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear behaviours. Here we challenge this assumption by leveraging mathematical models derived from measurements of local field potentials via intracra…
View article: Development of white matter fiber covariance networks supports executive function in youth
Development of white matter fiber covariance networks supports executive function in youth Open
View article: Generalizable links between symptoms of borderline personality disorder and functional connectivity
Generalizable links between symptoms of borderline personality disorder and functional connectivity Open
Background Symptoms of borderline personality disorder (BPD) often manifest in adolescence, yet the underlying relationship between these debilitating symptoms and the development of functional brain networks is not well understood. Here w…
View article: Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth Open
View article: Development of top-down cortical propagations in youth
Development of top-down cortical propagations in youth Open
View article: Personalized Functional Brain Network Topography Predicts Individual Differences in Youth Cognition
Personalized Functional Brain Network Topography Predicts Individual Differences in Youth Cognition Open
Individual differences in cognition during childhood are associated with important social, physical, and mental health outcomes in adolescence and adulthood. Given that cortical surface arealization during development reflects the brain’s …
View article: External drivers of BOLD signal’s non-stationarity
External drivers of BOLD signal’s non-stationarity Open
A fundamental challenge in neuroscience is to uncover the principles governing how the brain interacts with the external environment. However, assumptions about external stimuli fundamentally constrain current computational models. We show…
View article: Conserved whole-brain spatiomolecular gradients shape adult brain functional organization
Conserved whole-brain spatiomolecular gradients shape adult brain functional organization Open
Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, how these gradients relate to adult brain function, and whe…
View article: Curation of BIDS (CuBIDS): A workflow and software package for streamlining reproducible curation of large BIDS datasets
Curation of BIDS (CuBIDS): A workflow and software package for streamlining reproducible curation of large BIDS datasets Open
View article: Intrinsic Activity Develops Along a Sensorimotor-Association Cortical Axis in Youth
Intrinsic Activity Develops Along a Sensorimotor-Association Cortical Axis in Youth Open
Animal studies of neurodevelopmental plasticity have shown that intrinsic brain activity evolves from high amplitude and globally synchronized to suppressed and sparse as plasticity declines and the cortex matures. Leveraging resting-state…
View article: Sex differences in the functional topography of association networks in youth
Sex differences in the functional topography of association networks in youth Open
Prior work has shown that there is substantial interindividual variation in the spatial distribution of functional networks across the cerebral cortex, or functional topography. However, it remains unknown whether there are sex differences…
View article: CoCoA: conditional correlation models with association size
CoCoA: conditional correlation models with association size Open
Summary Many scientific questions can be formulated as hypotheses about conditional correlations. For instance, in tests of cognitive and physical performance, the trade-off between speed and accuracy motivates study of the two variables t…
View article: Model-based stationarity filtering of long-term memory data applied to resting-state blood-oxygen-level-dependent signal
Model-based stationarity filtering of long-term memory data applied to resting-state blood-oxygen-level-dependent signal Open
Resting-state blood-oxygen-level-dependent (BOLD) signal acquired through functional magnetic resonance imaging is a proxy of neural activity and a key mechanism for assessing neurological conditions. Therefore, practical tools to filter o…
View article: Information content of brain states is explained by structural constraints on state energetics
Information content of brain states is explained by structural constraints on state energetics Open
Signal propagation along the structural connectome of the brain induces changes in the patterns of activity. These activity patterns define global brain states and contain information in accordance with their expected probability of occurr…
View article: Development of Top-Down Cortical Propagations in Youth
Development of Top-Down Cortical Propagations in Youth Open
Hierarchical processing requires activity propagating between higher and lower-order cortical areas. However, studies of brain development have chiefly quantified fluctuations within regions over time rather than propagations occurring ove…
View article: ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion
ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion Open
View article: Dissociable multi-scale patterns of development in personalized brain networks
Dissociable multi-scale patterns of development in personalized brain networks Open
View article: Curation of BIDS (CuBIDS): a workflow and software package for streamlining reproducible curation of large BIDS datasets
Curation of BIDS (CuBIDS): a workflow and software package for streamlining reproducible curation of large BIDS datasets Open
The Brain Imaging Data Structure (BIDS) is a specification accompanied by a software ecosystem that was designed to create reproducible and automated workflows for processing neuroimaging data. BIDS Apps flexibly build workflows based on t…
View article: CoCoA: Conditional Correlation Models with Association Size
CoCoA: Conditional Correlation Models with Association Size Open
S ummary Many scientific questions can be formulated as hypotheses about conditional correlations. For instance, in tests of cognitive and physical performance, the trade-off between speed and accuracy motivates study of the two variables …
View article: Associations between neighborhood socioeconomic status, parental education, and executive system activation in youth
Associations between neighborhood socioeconomic status, parental education, and executive system activation in youth Open
Socioeconomic status (SES) can impact cognitive performance, including working memory (WM). As executive systems that support WM undergo functional neurodevelopment during adolescence, environmental stressors at both individual and communi…
View article: Broken detailed balance and entropy production in the human brain
Broken detailed balance and entropy production in the human brain Open
Significance To perform biological functions, living systems must break detailed balance by consuming energy and producing entropy. At microscopic scales, broken detailed balance enables a suite of molecular and cellular functions, includi…
View article: External drivers of BOLD signal’s non-stationarity
External drivers of BOLD signal’s non-stationarity Open
A fundamental challenge in neuroscience is to uncover the principles governing how the brain interacts with the external environment. However, assumptions about external stimuli fundamentally constrain current computational models. We show…
View article: Evaluating the sensitivity of functional connectivity measures to motion artifact in resting-state fMRI data
Evaluating the sensitivity of functional connectivity measures to motion artifact in resting-state fMRI data Open
View article: Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities
Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities Open
The Adolescent Brain Cognitive Development Study (ABCD), a 10 year longitudinal neuroimaging study of the largest population based and demographically distributed cohort of 9-10 year olds (N=11,877), was designed to overcome reproducibilit…
View article: Dissociable Multi-scale Patterns of Development in Personalized Brain Networks
Dissociable Multi-scale Patterns of Development in Personalized Brain Networks Open
SUMMARY The brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derived personalized functional networks across 29 scales in a large…
View article: Sex Differences in Functional Topography of Association Networks
Sex Differences in Functional Topography of Association Networks Open
Prior work has shown that there is substantial interindividual variation in the spatial distribution of functional networks across the cerebral cortex, or functional topography . However, it remains unknown whether there are sex difference…
View article: ASLPrep: A Generalizable Platform for Processing of Arterial Spin Labeled MRI and Quantification of Regional Brain Perfusion
ASLPrep: A Generalizable Platform for Processing of Arterial Spin Labeled MRI and Quantification of Regional Brain Perfusion Open
Arterial spin labeled (ASL) magnetic resonance imaging (MRI) is the primary method for non-invasively measuring regional brain perfusion in humans. We introduce ASLPrep, a suite of software pipelines that ensure the reproducible and genera…
View article: Is the brain macroscopically linear? A system identification of resting state dynamics
Is the brain macroscopically linear? A system identification of resting state dynamics Open
A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal fu…