Maxwell Murphy
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The Portable Microhaplotype Object and Tools Open
Structured Abstract Motivation The rapid increase in the generation of targeted sequencing data offers immense potential for research, medicine, and public health, however the lack of an established standard for these data has led to dispa…
View article: High connectivity and low differentiation of Plasmodium falciparum parasite populations in a setting with high seasonal migration
High connectivity and low differentiation of Plasmodium falciparum parasite populations in a setting with high seasonal migration Open
Seasonal movement of less-immune people from low- to high- transmission regions increase malaria risk and may introduce parasite strains to both areas. This study examined Plasmodium falciparum genetic diversity and connectivity between lo…
View article: Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns
Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns Open
Imported malaria is a critical obstacle to achieving elimination in low transmission settings. Characterising malaria importation and transmission sources using human mobility and parasite genomics has the potential to inform elimination s…
View article: Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns
Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns Open
Imported malaria is a critical obstacle to achieving elimination in low transmission settings. Characterising malaria importation and transmission sources using human mobility and parasite genomics has the potential to inform elimination s…
View article: Estimating probabilities of malaria importation in southern Mozambique through <i>P. falciparum</i> genomics and mobility patterns
Estimating probabilities of malaria importation in southern Mozambique through <i>P. falciparum</i> genomics and mobility patterns Open
Imported malaria is a critical obstacle to achieving elimination in low transmission settings. Characterising malaria importation and transmission sources using human mobility and parasite genomics has the potential to inform elimination s…
Classification of outcomes in antimalarial therapeutic efficacy studies with Aster Open
Reliable assessment of antimalarial drug efficacy is crucial for effective response to emerging drug resistance, and therapeutic efficacy studies (TES) are the primary means of estimating in vivo efficacy. Accuracy of such estimates rests …
Towards an open analysis ecosystem for <i>Plasmodium</i> genomic epidemiology Open
Major advances in Plasmodium sequencing approaches, bioinformatic pipelines, and data analysis tools have provided valuable insights into malaria epidemiology from parasite genomic data. However, translating genetic data into actionable in…
View article: Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis
Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis Open
Summary Background High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in East and Southern Africa has prompted numerous trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-p…
MOIRE: a software package for the estimation of allele frequencies and effective multiplicity of infection from polyallelic data Open
Motivation Malaria parasite genetic data can provide insight into parasite phenotypes, evolution, and transmission. However, estimating key parameters such as allele frequencies, multiplicity of infection (MOI), and within-host relatedness…
View article: Genomic epidemiology demonstrates spatially clustered, local transmission of Plasmodium falciparum in forest-going populations in southern Lao PDR
Genomic epidemiology demonstrates spatially clustered, local transmission of Plasmodium falciparum in forest-going populations in southern Lao PDR Open
While there has been significant progress in controlling falciparum malaria in the Lao People’s Democratic Republic (PDR), sporadic cases persist in southern provinces where the extent and patterns of transmission remain largely unknown. T…
View article: Genomic epidemiology demonstrates spatially clustered, local transmission of <i>Plasmodium falciparum</i> in forest-going populations in southern Lao PDR
Genomic epidemiology demonstrates spatially clustered, local transmission of <i>Plasmodium falciparum</i> in forest-going populations in southern Lao PDR Open
While there has been significant progress in controlling falciparum malaria in the Lao People’s Democratic Republic (PDR), sporadic cases persist in southern provinces where the extent and patterns of transmission remain largely unknown. T…
MOIRE: A software package for the estimation of allele frequencies and effective multiplicity of infection from polyallelic data Open
Motivation Malaria parasite genetic data can provide insight into parasite phenotypes, evolution, and transmission. However, estimating key parameters such as allele frequencies, multiplicity of infection (MOI), and within-host relatedness…
A test combining multiplex-PCR with pooled antibiotic susceptibility testing has high correlation with expanded urine culture for detection of live bacteria in urine samples of suspected UTI patients Open
We evaluated whether multiplex polymerase chain reaction (M-PCR) detects viable micro-organisms by comparing micro-organism identification with standard urine culture (SUC) and expanded quantitative urine culture (EQUC). Of the 395 organis…
Anopheles stephensi is implicated in an outbreak of Plasmodium falciparum parasites that carry markers of drug and diagnostic resistance in Dire Dawa City, Ethiopia, January–July 2022 Open
Anopheles stephensi , an Asian urban malaria vector, continues to expand across Africa. We investigated the role of An. stephensi in malaria transmission following a dry season outbreak in Dire Dawa, Ethiopia, from April to July 2022, usin…
Association between indoor residual spraying and pregnancy outcomes: a quasi-experimental study from Uganda Open
Background Malaria is a risk factor for adverse pregnancy outcomes. Indoor residual spraying with insecticide (IRS) reduces malaria infections, yet the effects of IRS on pregnancy outcomes are not well established. We evaluated the impact …
Within‐household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda Open
Background Evaluation of genetic relatedness of malaria parasites is a useful tool for understanding transmission patterns, but patterns are not easily detectable in areas with moderate to high malaria transmission. To evaluate the feasibi…
Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda Open
Background Evaluation of genetic relatedness of malaria parasites is a useful tool for understanding transmission patterns, but patterns are not easily detectable in areas with moderate to high malaria transmission. To evaluate the feasibi…
Within-Household Clustering of Genetically Related Plasmodium Falciparum Infections In A Moderate Transmission Area of Uganda Open
Background: Evaluation of genetic relatedness of malaria parasites is a useful tool for understanding transmission patterns, but patterns are not easily detectable in areas with moderate to high malaria transmission. To evaluate the feasib…
Inferring person-to-person networks of <i>Plasmodium falciparum</i> transmission: is routine surveillance data up to the task? Open
Inference of person-to-person transmission networks using surveillance data is increasingly used to estimate spatiotemporal patterns of pathogen transmission. Several data types can be used to inform transmission network inferences, yet th…
Sensitive, Highly Multiplexed Sequencing of Microhaplotypes From the <i>Plasmodium falciparum</i> Heterozygome Open
Background Targeted next-generation sequencing offers the potential for consistent, deep coverage of information-rich genomic regions to characterize polyclonal Plasmodium falciparum infections. However, methods to identify and sequence th…
Multiplex Human Malaria Array: Quantifying Antigens for Malaria Rapid Diagnostics Open
Malaria antigen detection through rapid diagnostic tests (RDTs) is widely used to diagnose malaria and estimate prevalence. To support more sensitive next-generation RDT development and screen asymptomatic malaria, we developed and evaluat…
Sensitive, highly multiplexed sequencing of microhaplotypes from the <i>Plasmodium falciparum</i> heterozygome Open
Background Targeted next generation sequencing offers the potential for consistent, deep coverage of information rich genomic regions to characterize polyclonal Plasmodium falciparum infections. However, methods to identify and sequence th…