Maxwell T. Laws
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View article: Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas
Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas Open
Schwann cell tumors occur frequently in association with the vestibular nerves, leading to sensorineural hearing loss, and brainstem compression. In humans, unilateral vestibular schwannomas (VS) occur sporadically (VS spo ) 1 , or bilater…
View article: SUN-323 Metastasis to the Clivus - a Unique Presentation of Metastatic Medullary Thyroid Cancer Associated with Multiple Endocrine Neoplasia Type 2A
SUN-323 Metastasis to the Clivus - a Unique Presentation of Metastatic Medullary Thyroid Cancer Associated with Multiple Endocrine Neoplasia Type 2A Open
Disclosure: D. Al-Souri: None. E. Chuki: None. P. Chittiboina: None. D. Smart: None. J. Diamond: None. M. Laws: None. P. Veeraraghavan: None. S. Gubbi: None. J. Klubo-Gwiezdzinska: None. Introduction: Medullary thyroid carcinoma (MTC) is a…
View article: EPCO-54. MULTIOMIC ANALYSIS OF SPINAL EPENDYMOMAS REVEALS MECHANISMS OF TUMOR AGGRESSIVENESS WITH MYCN AMPLIFICATION
EPCO-54. MULTIOMIC ANALYSIS OF SPINAL EPENDYMOMAS REVEALS MECHANISMS OF TUMOR AGGRESSIVENESS WITH MYCN AMPLIFICATION Open
Grade-3 spinal ependymomas, particularly those harboring MYCN amplification, have dismal prognoses despite optimal treatment regimens. MYCN functions as a transcription factor (TF) to drive the expression of key tumor driver genes. Our aim…
View article: CSIG-19. IDENTIFICATION AND TARGETING OF TUMOR DRIVER SCHWANN(NF2LOSS) CELLS IN SPORADIC AND NF2-RELATED VESTIBULAR SCHWANNOMAS
CSIG-19. IDENTIFICATION AND TARGETING OF TUMOR DRIVER SCHWANN(NF2LOSS) CELLS IN SPORADIC AND NF2-RELATED VESTIBULAR SCHWANNOMAS Open
Vestibular schwannomas (VS) arise from myelinating Schwann cells of CN VIII and are associated with severe morbidity due to local tumor growth. Sporadic and neurofibromatosis type 2 (NF2) associated VS are both characterized by NF2 (merlin…
View article: Glioblastoma may evade immune surveillance through primary cilia-dependent signaling in an IL-6 dependent manner
Glioblastoma may evade immune surveillance through primary cilia-dependent signaling in an IL-6 dependent manner Open
Glioblastoma is the most common, malignant primary brain tumor in adults and remains universally fatal. While immunotherapy has vastly improved the treatment of several solid cancers, efficacy in glioblastoma is limited. These challenges a…
View article: TMIC-09. PRIMARY CILIA REGULATE EXTRACELLULAR VESICLE-MEDIATED IMMUNOSUPPRESSION IN HUMAN GLIOBLASTOMA CELLS
TMIC-09. PRIMARY CILIA REGULATE EXTRACELLULAR VESICLE-MEDIATED IMMUNOSUPPRESSION IN HUMAN GLIOBLASTOMA CELLS Open
Glioblastoma is the most common primary malignant brain tumor. Despite maximal safe resection, followed by chemoradiation, median survival is 15 months, and 5-year survival is 6.8%. Efficacy of immunotherapy is limited by glioblastoma-medi…
View article: Dorsal cervical approach for recurrent intradural anaplastic ependymoma
Dorsal cervical approach for recurrent intradural anaplastic ependymoma Open
The video demonstrates an operative approach to a recurrent cervical anaplastic ependymoma. MYCN-amplified anaplastic ependymomas are locally aggressive, recurrent, and have a high risk of iatrogenic injury. In this case, the patient prese…
View article: The role of the dura mater in cerebral metastases
The role of the dura mater in cerebral metastases Open
OBJECTIVE The objective of this review was to describe the immunological changes that take place in the dura mater in response to metastatic disease that seeds the CNS. The authors hypothesized that the dura’s anatomy and resident immune c…
View article: Noninvasive quantification of SIRT1 expression–activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI
Noninvasive quantification of SIRT1 expression–activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI Open
Background Several studies demonstrated that glioblastoma multiforme progression and recurrence is linked to epigenetic regulatory mechanisms. Sirtuin 1 (SIRT1) plays an important role in glioma progression, invasion, and treatment respons…
View article: Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA
Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA Open
HDAC class IIa enzymes (HDAC4, 5, 7, 9) are important for glioma progression, invasion, responses to TMZ and radiotherapy, and prognosis. In this study, we demonstrated the efficacy of PET/CT/(MRI) with [ 18 F]TFAHA for non-invasive and qu…
View article: Molecular Imaging of Sirtuin1 Expression–Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [<sup>18</sup>F]-2-Fluorobenzoylaminohexanoicanilide
Molecular Imaging of Sirtuin1 Expression–Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [<sup>18</sup>F]-2-Fluorobenzoylaminohexanoicanilide Open
Sirtuin 1 (SIRT1) is a class III histone deacetylase that plays significant roles in the regulation of lifespan, metabolism, memory, and circadian rhythms and in the mechanisms of many diseases. However, methods of monitoring the pharmacod…
View article: A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography
A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography Open
The next generation of SIRT2-specific radiotracers resistant to systemic defluorination should be developed using alternative sites of radiofluorination on the aliphatic chain of DDAHA. A SIRT2-selective radiotracer may provide information…