May A. Beamer
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View article: Umbribacter vaginalis gen. nov., sp. nov.: novel bacterium isolated from the human vagina
Umbribacter vaginalis gen. nov., sp. nov.: novel bacterium isolated from the human vagina Open
Gram-variable obligately anaerobic novel bacteria DNF00809 and PR-HUZ-602407-17 were isolated from vaginal fluid samples from women with bacterial vaginosis (BV) in two independent studies conducted in different laboratories. They each dis…
View article: Phase 1 randomized pharmacokinetic and safety study of a 90‐day tenofovir vaginal ring in the United States
Phase 1 randomized pharmacokinetic and safety study of a 90‐day tenofovir vaginal ring in the United States Open
Introduction Tenofovir‐based oral pre‐exposure prophylaxis is currently approved for HIV prevention; however, adherence in women has been low. A vaginal gel containing tenofovir (TFV) demonstrated partial protection to HIV but protection w…
View article: Amygdalobacter indicium gen. nov., sp. nov., and Amygdalobacter nucleatus sp. nov., gen. nov.: novel bacteria from the family Oscillospiraceae isolated from the female genital tract
Amygdalobacter indicium gen. nov., sp. nov., and Amygdalobacter nucleatus sp. nov., gen. nov.: novel bacteria from the family Oscillospiraceae isolated from the female genital tract Open
Four obligately anaerobic Gram-positive bacteria representing one novel genus and two novel species were isolated from the female genital tract. Both novel species, designated UPII 610-J T and KA00274 T , and an additional isolate of each …
View article: Tenofovir vaginal film as a potential MPT product against HIV-1 and HSV-2 acquisition: formulation development and preclinical assessment in non-human primates
Tenofovir vaginal film as a potential MPT product against HIV-1 and HSV-2 acquisition: formulation development and preclinical assessment in non-human primates Open
Tenofovir (TFV) is an adenosine nucleotide analog with activity against HIV and HSV-2. Secondary analyses of clinical trials evaluating TFV gel as pre-exposure prophylaxis (PrEP) for HIV have shown that gel formulations of TFV provide sign…
View article: Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States
Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States Open
Introduction Vaginal rings are a promising approach to provide a woman‐centred, long‐acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction …
View article: Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study
Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study Open
The Microbicide Trials Network and the National Institute of Allergy and Infectious Diseases, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health, all components …
View article: Zim CHIC: A cohort study of immune changes in the female genital tract associated with initiation and use of contraceptives
Zim CHIC: A cohort study of immune changes in the female genital tract associated with initiation and use of contraceptives Open
Problem Contraceptive hormones are systemically active, potent, and likely to invoke biological responses other than known fertility regulation impacts. We hypothesized that initiation of depot medroxyprogesterone acetate (DMPA) would incr…
View article: Optimization of processing female genital tissue samples for lymphocyte analysis by flow cytometry
Optimization of processing female genital tissue samples for lymphocyte analysis by flow cytometry Open
Problem A variety of methods have been used to process cervical cytobrush and genital tissue for flow cytometric evaluation of immune cell populations. We sought to optimize genital tract specimen processing and to determine if blood could…
View article: P366 An evaluation of the BD MAX™ vaginal panel compared to the nugent score for diagnosis of bacterial vaginosis (BV)
P366 An evaluation of the BD MAX™ vaginal panel compared to the nugent score for diagnosis of bacterial vaginosis (BV) Open
Background The Nugent criteria have been used as a comparator to Amsel criteria for diagnosis of BV. The BD MAX™ Vaginal Panel (MVP) received market authorization by the FDA as a molecular test to aid in the diagnosis of vaginitis/vaginosi…
View article: P365 Microbial risk factors for acquisition of symptomatic Bacterial Vaginosis (BV)
P365 Microbial risk factors for acquisition of symptomatic Bacterial Vaginosis (BV) Open
Background Vaginal dysbiosis is common among women of reproductive age but many women having vaginal dysbiosis do not develop symptomatic BV requiring treatment. Our objective was to identify microbiota using quantitative PCR (qPCR) which …
View article: Megasphaera lornae sp. nov., Megasphaera hutchinsoni sp. nov., and Megasphaera vaginalis sp. nov.: novel bacteria isolated from the female genital tract
Megasphaera lornae sp. nov., Megasphaera hutchinsoni sp. nov., and Megasphaera vaginalis sp. nov.: novel bacteria isolated from the female genital tract Open
Six strictly anaerobic Gram-negative bacteria representing three novel species were isolated from the female reproductive tract. The proposed type strains for each species were designated UPII 199-6 T , KA00182 T and BV3C16-1 T . Phylogene…
View article: Phase 1 Pharmacokinetic Trial of 2 Intravaginal Rings Containing Different Dose Strengths of Vicriviroc (MK-4176) and MK-2048
Phase 1 Pharmacokinetic Trial of 2 Intravaginal Rings Containing Different Dose Strengths of Vicriviroc (MK-4176) and MK-2048 Open
In this first study evaluating 2 doses of a combination VCV/MK-2048 VR, both rings were found to be safe and well tolerated. VCV and MK-2048 were detectable in plasma, CVF, and cervical tissue samples, and drug release and plasma drug expo…
View article: Bacterial species colonizing the vagina of healthy women are not associated with race
Bacterial species colonizing the vagina of healthy women are not associated with race Open