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View article: Gene architecture is a determinant of the transcriptional response to bulky DNA damages
Gene architecture is a determinant of the transcriptional response to bulky DNA damages Open
Bulky DNA damages block transcription and compromise genome integrity and function. The cellular response to these damages includes global transcription shutdown. Still, active transcription is necessary for transcription-coupled repair an…
View article: Exons and introns exhibit transcriptional strand asymmetry of dinucleotide distribution, damage formation and DNA repair
Exons and introns exhibit transcriptional strand asymmetry of dinucleotide distribution, damage formation and DNA repair Open
Recent cancer sequencing efforts have uncovered asymmetry in DNA damage induced mutagenesis between the transcribed and non-transcribed strands of genes. Here, we investigate the major type of damage induced by ultraviolet (UV) radiation, …