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View article: MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans
MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans Open
In response to the COVID-19 pandemic, multiple vaccines were developed using platforms such as viral vectors and mRNA technology. Here, we report humoral and cellular immunogenicity data from human phase 1 clinical trials investigating two…
View article: Neoadjuvant Therapy with Everolimus for Subependymal Giant Cell Astrocytoma: A Case Report
Neoadjuvant Therapy with Everolimus for Subependymal Giant Cell Astrocytoma: A Case Report Open
Direct surgical resection remains to be the standard treatment for tuberous sclerosis complex (TSC) with subependymal giant cell astrocytoma (SEGA). Medical therapy with everolimus (mammalian target of rapamycin inhibitor or mTOR) serves a…
View article: Molecular Investigation of Brain Tumors Progressing During Pregnancy or Postpartum Period: The Association Between Tumor Type, Their Receptors, and the Timing of Presentation
Molecular Investigation of Brain Tumors Progressing During Pregnancy or Postpartum Period: The Association Between Tumor Type, Their Receptors, and the Timing of Presentation Open
Brain tumors are frequently present during pregnancy; however, the mechanism has not been well elucidated. Purpose of this study is to investigate the influence of molecular genetic factors on the progression of brain tumors during pregnan…
View article: Adult Langerhans Cell Histiocytosis Diagnosed by Biopsy of the Skull Tumor Generated after Craniotomy
Adult Langerhans Cell Histiocytosis Diagnosed by Biopsy of the Skull Tumor Generated after Craniotomy Open
Langerhans cell histiocytosis (LCH) is a disease characterized by the proliferation of Langerhans cells. Most cases of LCH occur in children, although it can be seen in adults as well. We encountered an adult case of LCH. A 44-year-old wom…
View article: GCT-47. TREATMENT STRATEGIES FOR GIANT IMMATURE TERATOMAS IN INFANTS
GCT-47. TREATMENT STRATEGIES FOR GIANT IMMATURE TERATOMAS IN INFANTS Open
INTRODUCTION Immature teratomas are the most frequent fetal brain tumors and show a poor prognosis. At onset, the tumor is often already giant with deep origins such as suprasellar or pineal region, and easy bleeding is also considered to …
View article: GCT-55. INTRACRANIAL GERMINOMA ORIGINATING FROM ATYPICAL LOCATION WITH SUBCLINICAL ADH INSUFFICIENCY
GCT-55. INTRACRANIAL GERMINOMA ORIGINATING FROM ATYPICAL LOCATION WITH SUBCLINICAL ADH INSUFFICIENCY Open
INTRODUCTION Intracranial germinomas are rare tumors which usually develop in the midline structures and affect in 90% of cases the pineal gland and suprasellar regions. Sometimes they involve basal ganglia, septum pellucidum, and other re…
View article: Interneuronal NMDA receptors regulate long‐term depression and motor learning in the cerebellum
Interneuronal NMDA receptors regulate long‐term depression and motor learning in the cerebellum Open
Key points NMDA receptors (NMDARs) are required for long‐term depression (LTD) at parallel fibre–Purkinje cell synapses, but their cellular localization and physiological functions in vivo are unclear. NMDARs in molecular‐layer interneuron…
View article: P09.50 Phase I trial of temozolomide plus bevacizumab for newly diagnosed high-grade gliomas in the elderly: Interim report
P09.50 Phase I trial of temozolomide plus bevacizumab for newly diagnosed high-grade gliomas in the elderly: Interim report Open
\nIntroduction: Although more than 10% of glioblastomas arises in the elderly over 75 y/o, treatment options for these patients are very limited. Randomized clinical trials suggested that bevacizumab (BEV) administration is associated with…
View article: MPTH-08. MOLECULAR INVESTIGATION OF BRAIN TUMORS PROGRESSING DURING PREGNANCY
MPTH-08. MOLECULAR INVESTIGATION OF BRAIN TUMORS PROGRESSING DURING PREGNANCY Open
Brain tumors often manifest or progress during pregnancy such as meningiomas, gliomas, and pituitary adenomas. Although its mechanism has not been elucidated well, the literature suggests the presumable association of sex hormones and othe…
View article: Histopathological investigation of glioblastomas resected under bevacizumab treatment
Histopathological investigation of glioblastomas resected under bevacizumab treatment Open
To date, no clinical observations have been reported for histopathological changes in human gliomas under antiangiogenic treatment.We collected six glioblastomas resected under bevacizumab treatment. Histopathological investigation was per…
View article: A MORN1-associated HAD phosphatase in the basal complex is essential for<i>Toxoplasma gondii</i>daughter budding
A MORN1-associated HAD phosphatase in the basal complex is essential for<i>Toxoplasma gondii</i>daughter budding Open
Apicomplexan parasites replicate by several budding mechanisms with two well-characterized examples being Toxoplasma endodyogeny and Plasmodium schizogony. Completion of budding requires the tapering of the nascent daughter buds toward the…
View article: Pellicle formation in the malaria parasite
Pellicle formation in the malaria parasite Open
The intraerythrocytic developmental cycle of Plasmodium falciparum is completed with the release of up to 32 invasive daughter cells, the merozoites, into the blood stream. Prior to release, the finalizing step of merozoite development is …