Maya L. Gosztyla
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View article: An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine
An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine Open
Quantification of cellular lipids in a reproducible and high-throughput manner is a key step in the development of therapeutics for lipid storage diseases. Niemann-Pick Disease Type C (NPC) is a genetic disorder characterized by the accumu…
View article: Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders Open
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry to characterize the synap…
View article: Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation Open
View article: Author Correction: Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion
Author Correction: Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion Open
View article: Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration Open
Muscular atrophy is a mortality risk factor that happens with disuse, chronic disease, and aging. Recovery from atrophy requires changes in several cell types including muscle fibers, and satellite and immune cells. Here we show that Zfp69…
View article: HydRA: Deep-Learning Models for Predicting RNA-Binding Capacity from Protein Interaction Association Context and Protein Sequence
HydRA: Deep-Learning Models for Predicting RNA-Binding Capacity from Protein Interaction Association Context and Protein Sequence Open
View article: HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence
HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence Open
RNA-binding proteins (RBPs) control RNA metabolism to orchestrate gene expression, and dysfunctional RBPs underlie many human diseases. Proteome-wide discovery efforts predict thousands of novel RBPs, many of which lack canonical RNA-bindi…
View article: RNA-Targeting CRISPR/Cas13d System Eliminates Disease-Related Phenotypes in Pre-clinical Models of Huntington’s Disease
RNA-Targeting CRISPR/Cas13d System Eliminates Disease-Related Phenotypes in Pre-clinical Models of Huntington’s Disease Open
Huntington’s disease (HD) is a fatal, dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in exon 1 of the huntingtin ( HTT ) gene. Although the pathogenesis of HD remains complex, the CAG-expanded (CAG …
View article: A multi-scale map of cell structure fusing protein images and interactions
A multi-scale map of cell structure fusing protein images and interactions Open
View article: Responses to 10 common criticisms of anti-racism action in STEMM
Responses to 10 common criticisms of anti-racism action in STEMM Open
The wrongful murders of Black individuals during 2020 (including George Floyd, Breonna Taylor, Ahmaud Aubery, and others), compounded by a long history of similar incidents, inspired protests around the world against racism and police brut…
View article: A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers
A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers Open
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in …
View article: Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences
Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences Open
Quality control monitoring of cell lines utilized in biomedical research is of utmost importance and is critical for the reproducibility of data. Two key pitfalls in tissue culture are 1) cell line authenticity and 2) Mycoplasma con…
View article: Keeping it clean: the cell culture quality control experience at the National Center for Advancing Translational Sciences
Keeping it clean: the cell culture quality control experience at the National Center for Advancing Translational Sciences Open
Quality control monitoring of cell lines utilized in biomedical research is of critical importance, and is critical for reproducibility of data. Two key pitfalls in tissue culture are 1) cell line authenticity, and 2) mycoplasma contaminat…
View article: The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease
The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease Open
Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis of Alzheimer's disease (AD), and it is currently the primary therapeutic target in attempts to arrest the course of this disease. This notoriety has…
View article: Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence
Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence Open
The amyloid-β (Aβ) peptide has long been considered to be the driving force behind Alzheimer’s disease (AD). However, clinical trials that have successfully reduced Aβ burden in the brain have not slowed the cognitive decline, and in some …
View article: Consequences of redefining Alzheimer's disease in terms of amyloid burden without regard to cognitive decline
Consequences of redefining Alzheimer's disease in terms of amyloid burden without regard to cognitive decline Open
Alzheimer's disease (AD) redefined: For the past century, AD has been defined as a disease of progressive cognitive decline paired with a burden of amyloid-β (Aβ) plaques and pathologic tau tangles in the hippocampus and forebrain. However…
View article: Genome-Wide Association Analysis of Midline Axon Guidance in the Drosophila melanogaster Genetic Reference Panel
Genome-Wide Association Analysis of Midline Axon Guidance in the Drosophila melanogaster Genetic Reference Panel Open
The central nervous system (CNS) midline is an important choice point for many pathfinding axons during neural development. Previous studies have searched for novel regulators using mutagenesis experiments involving a few inbred laboratory…