Maya M. Polovitskaya
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View article: LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation
LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation Open
Volume-regulated anion channels (VRACs) are almost ubiquitously expressed plasma membrane (PM) channels of vertebrate cells with roles in cell volume regulation and signaling. Besides conducting anions such as chloride, VRACs transport met…
View article: Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease
Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease Open
View article: Molecular basis of ClC-6 function and its impairment in human disease
Molecular basis of ClC-6 function and its impairment in human disease Open
ClC-6 is a late endosomal voltage-gated chloride-proton exchanger that is predominantly expressed in the nervous system. Mutated forms of ClC-6 are associated with severe neurological disease. However, the mechanistic role of ClC-6 in norm…
View article: Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels Open
Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity, but the underlying mechanis…
View article: KCNQ5 controls perivascular adipose tissue-mediated vasodilation
KCNQ5 controls perivascular adipose tissue-mediated vasodilation Open
Background Small arteries exhibit resting tone, a partially contracted state that maintains arterial blood pressure. In arterial smooth muscle cells (SMCs), potassium channels control contraction and relaxation. Perivascular adipose tissue…
View article: Gating choreography and mechanism of the human proton-activated chloride channel ASOR
Gating choreography and mechanism of the human proton-activated chloride channel ASOR Open
The proton-activated chloride channel ASOR (TMEM206/PAC) permeates anions across cellular membranes in response to acidification, thereby enhancing acid-induced cell death and regulating endocytosis. The molecular mechanisms of pH-dependen…
View article: Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders
Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders Open
View article: A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl−/H+-Exchanger, Causes Early-Onset Neurodegeneration
A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl−/H+-Exchanger, Causes Early-Onset Neurodegeneration Open
View article: LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)
LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs) Open