Mahasen A. Radwan
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View article: Implementing Cytochrome P450 Pharmacogenomics in Clinical Practice: A Glimmer of Hope or Simply a Mirage?
Implementing Cytochrome P450 Pharmacogenomics in Clinical Practice: A Glimmer of Hope or Simply a Mirage? Open
Even though pharmacogenomics approaches are becoming progressively more advanced, opinions on their clinical validity and implementation remain controversial. To ascertain whether cytochrome P450 (CYPs) pharmacogenomics could be favorably …
View article: CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin
CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin Open
Background A single nucleotide polymorphism (SNP) is a variation in the DNA sequence that results from the alteration of a single nucleotide in the genome. Atorvastatin is used to treat hypercholesterolemia. It belongs to a class of drugs …
View article: Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity
Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity Open
Cyclodextrin nanosponges are solid nanoparticles, designed by cross-linking of cyclodextrin polymer; it has been used widely as a good delivery system for water insoluble drugs. The aim of this study is to enhance the solubility of Piroxic…
View article: Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats
Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats Open
Amphotericin B (AMB) is used most commonly in severe systemic life-threatening fungal infections. There is currently an unmet need for an efficacious (AMB) formulation amenable to oral administration with better bioavailability and lower n…