Explanipedia

Hydrazone bimetallic complex: synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA Open

Mayada S. Ali, Dhanachandra Kuraijam, Sadashiva S. Karnik, Laila A. Jaragh-Alhadad · 2022

Manganese complex of (N'1E,N'3E)-N'1,N'3-bis(2-hydroxybenzylidene)isophthalo-hydrazide [H4L] was designed, spectroscopically analyzed, and confirmed via GC-MS, FTIR, CHNS, UV-VIS, magnetic susceptibility measurements, and molar electric co…

Sulfonamide derivatives mediate breast and lung cancer cell line killing through tubulin inhibition Open

Laila A. Jaragh-Alhadad, Mayada S. Ali, Moustafa S. Moustafa, Gamaleldin I. Harisa, Fars K. Alanazi , et al. · 2022

Tubulin plays essential roles in cell signaling, division, proliferation, and other cellular functions. Tubulin is a potential target for anticancer agents. The classical tubulin inhibitors have a low therapeutic index, multi-drug resistan…

Low-density lipoprotein encapsulated thiosemicarbazone metal complexes is active targeting vehicle for breast, lung, and prostate cancers Open

Laila A. Jaragh-Alhadad, Mayada S. Ali, Terri J. Harford, Sadashiva S. Karnik · 2022

Cancer is a leading cause of death worldwide and affects society in terms of the number of lives lost. Current cancer treatments are based on conventional chemotherapy which is nonspecific in targeting cancer. Therefore, intensive efforts …

Camel milk exosomes had a selective anticancer effect on PANC1 cells and a proliferative effect on H6c7 cells Open

Mayada S. Ali, Gehad El‐Sayed, Mohamed Salama, Mohammed A. El‐Magd · 2022

Background/aim: In the Middle East, there is a common belief that the daily intake of camel milk prevents cancer and diabetes. However, the actual anti-cancer and anti-diabetic mechanisms of camel milk remain elusive. This study aimed to e…

CCDC 2116516: Experimental Crystal Structure Determination Open

Laila A. Jaragh-Alhadad, Mayada S. Ali · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Methoxybenzamide derivative of nimesulide from anti-fever to anti-cancer: Chemical characterization and cytotoxicity Open

Laila A. Jaragh-Alhadad, Mayada S. Ali · 2022

The repurposing strategy of converting nimesulide from an anti-fever drug to an anti-cancer agent by modifying its main structure targeting HSP27 is gaining great attention these days. The goal of this study focuses on synthesizing a new n…

Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer: synthesis, characterization, biological assessment, and crystal structure. Open

Laila A. Jaragh-Alhadad, Mayada S. Ali · 2022

New nimesulide derivatives (A1-A6) were synthesized and investigated by IR, 1H NMR, 13C NMR, melting point, elemental analysis, mass spectra, and DSC analysis. Agent A3 single crystal was grown and solved in a monoclinic crystal system wit…

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions Open

Ahmed A. El‐Asmy, Bakir Jeragh, Mayada S. Ali · 2016

New chelating agent, N ' 1 , N ' 6 - bis (( E )-3,4-dihydroxybenzylidene)adipohydrazide (DBAH) was synthesized and its crystal structure was analyzed by X-ray single crystal diffractometer. Homometallic complexes of Zr(IV), Co(II), Ni(II),…

Synthesis and characterization of tri- and tetra-metallic complexes of N'1,N'4-bis((E)-3,4-dihydroxybenzylidene)-succinohydrazide Open

Ahmed Abd-Elhamied El-Asmy, Bakir Jeragh, Mayada S. Ali · 2016

Single crystal of N ' 1 , N ' 4 - bis (( E )-3,4-dihydroxybenzylidene)succinohydrazide (SHBH) was grown by slow evaporation method. Its, Co(II), Ni(II), Cu(II), Zn(II), Co(II)/Zn(II), Ni(II)/Zn(II) and Cu(II)/Zn(II) complexes have been pre…

CCDC 1476815: Experimental Crystal Structure Determination Open

Bakir Jeragh, Mayada S. Ali, Ahmed A. El‐Asmy · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 985982: Experimental Crystal Structure Determination Open

Ahmed El‐Asmy, Bakir Jeragh, Mayada S. Ali · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1475584: Experimental Crystal Structure Determination Open

Fathy A. El‐Saied, Mayada S. Ali, Mohamad M.E. Shakdofa, Ahmed A. El‐Asmy, Reham M.W. Faried , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1475581: Experimental Crystal Structure Determination Open

Mayada S. Ali, Fathy A. El‐Saied, Mohamad M.E. Shakdofa, Sadashiva S. Karnik, Laila A. Jaragh-Alhadad · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1476553: Experimental Crystal Structure Determination Open

Fathy A. El‐Saied, Mayada S. Ali, Mohamad M.E. Shakdofa, Ahmed A. El‐Asmy, Metwally Madkour · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1478956: Experimental Crystal Structure Determination Open

Fathy A. El‐Saied, Mohamad M.E. Shakdofa, Mayada S. Ali, Reham M.W. Faried, Ahmed El‐Asmy , et al. · 2016

CCDC 1476357: Experimental Crystal Structure Determination Open

Fathy A. El‐Saied, Mohamad M.E. Shakdofa, Mayada S. Ali, Reham M.W. Faried, Ahmed El‐Asmy , et al. · 2016

Spectral, thermal, molecular modeling and biological studies on mono- and binuclear complexes derived from oxalo bis(2,3-butanedionehydrazone) Open

Ahmed El‐Asmy, Bakir Jeragh, Mayada S. Ali · 2015

CCDC 967825: Experimental Crystal Structure Determination Open

Bakir Jeragh, Mayada S. Ali, Ahmed A. El‐Asmy · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1003036: Experimental Crystal Structure Determination Open

Bakir Jeragh, Mayada S. Ali, Ahmed A. El‐Asmy · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 968028: Experimental Crystal Structure Determination Open

Bakir Jeragh, Mayada S. Ali, Ahmed A. El‐Asmy · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 967823: Experimental Crystal Structure Determination Open

Bakir Jeragh, Mayada S. Ali, Ahmed A. El‐Asmy · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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