Mayer M. Chalom
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View article: Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity
Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity Open
Type 2 innate lymphoid cells (ILC2s) regulate the proliferation of preadipocytes that give rise to beige adipocytes. Whether and how ILC2 downstream Th2 cytokines control beige adipogenesis remain unclear. We used cell systems and genetic …
View article: Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis
Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis Open
Mitophagy and mitochondrial integrated stress response (ISR) are 2 primary protective mechanisms to maintain functional mitochondria. Whether these 2 processes are coordinately regulated remains unclear. Here we show that mitochondrial fis…
View article: Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise Open
IL-13 hits the gym Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen et al. report a d…