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View article: Mycobacterium tuberculosis growth inhibition by peripheral blood mononuclear cells from household contacts is not affected by previous SARS-CoV-2 infection
Mycobacterium tuberculosis growth inhibition by peripheral blood mononuclear cells from household contacts is not affected by previous SARS-CoV-2 infection Open
Background There is a concern that SARS-CoV-2 infection may drive poor outcomes after Mycobacterium tuberculosis Mtb exposure and infection. We performed an ex vivo Mtb killing assay using peripheral blood mononuclear cells (PBMC) from th…
View article: Immunologic and vascular biomarkers of mortality in critical COVID-19 in a South African cohort
Immunologic and vascular biomarkers of mortality in critical COVID-19 in a South African cohort Open
Introduction Biomarkers predicting mortality among critical Coronavirus disease 2019 (COVID-19) patients provide insight into the underlying pathophysiology of fatal disease and assist with triaging of cases in overburdened settings. Howev…
View article: Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research
Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research Open
Bronchoalveolar lavage (BAL) is becoming a common procedure for research into infectious disease immunology. Little is known about the clinical factors which influence the main outcomes of the procedure. In research participants who underw…
View article: Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research
Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research Open
Bronchoalveolar lavage (BAL) is becoming a common procedure for research into infectious disease immunology. Little is known about the clinical factors which influence the main outcomes of the procedure. In research participants who underw…
View article: Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis
Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis Open
TB is a highly infectious disease, with granulomas as its hallmark. Granulomas play an important role in the control of M. tuberculosis infection and as such are crucial indicators for our understanding of host resistance to TB.
View article: Establishment of a Patient-Derived, Magnetic Levitation-Based, 3D Spheroid Granuloma Model for Human Tuberculosis
Establishment of a Patient-Derived, Magnetic Levitation-Based, 3D Spheroid Granuloma Model for Human Tuberculosis Open
Tuberculous granulomas that develop in response to Mycobacterium tuberculosis ( M.tb ) infection are highly dynamic entities shaped by the host immune response and disease kinetics. Within this microenvironment, immune cell recruitment, po…
View article: Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa Open
Background Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 seroprevalence and the specificity of anti-SARS-CoV-2 antibody…
View article: Higher SARS-CoV-2 Seroprevalence in Workers with Lower Socioeconomic Status in Cape Town, South Africa.
Higher SARS-CoV-2 Seroprevalence in Workers with Lower Socioeconomic Status in Cape Town, South Africa. Open
Background: South Africa has a high degree of inequality between population groups. The first wave of COVID-19 may have affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 seroprevalence and the specificit…
View article: Modelling of the invasion dynamics of plasmodium falciparum merozoites into red blood cells
Modelling of the invasion dynamics of plasmodium falciparum merozoites into red blood cells Open