Mayra Carneiro
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View article: 384 Features of neoantigen-reactive T cells with <i>ex vivo</i> expansion capacity
384 Features of neoantigen-reactive T cells with <i>ex vivo</i> expansion capacity Open
View article: Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer
Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer Open
Characterizing T cell populations and understanding their developmental relationships may help design more effective cancer immunotherapies. We coupled single-cell transcriptomics and T cell receptor (TCR) αβ profiling of intratumoral and …
View article: High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer
High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer Open
Background Hydrolysis of extracellular ATP to adenosine (eADO) is an important immune checkpoint in cancer immunology. We here investigated the impact of the eADO pathway in high-grade serous ovarian cancer (HGSC) using multiparametric pla…
View article: CAR-T cells generated using Sleeping Beauty vectors and expanded with a lymphoblastoid cell line (LCL) display in vivo antitumor activity
CAR-T cells generated using Sleeping Beauty vectors and expanded with a lymphoblastoid cell line (LCL) display in vivo antitumor activity Open
View article: Frequency and clinical impact of compound mutation in chronic myeloid leukemia patients resistant to tyrosine kinase inhibitor
Frequency and clinical impact of compound mutation in chronic myeloid leukemia patients resistant to tyrosine kinase inhibitor Open
Background: Chronic myeloid leukemia is characterized by onco-protein BCR-ABL1 which is constitutively activated. This particularity allowed the development of the first specific tyrosine kinase inhibitor (TKI) which changed the course of …
View article: Production of chimeric antigen receptor (CAR)-T cells for preclinical testing using non-viral transposon vectors and a lymphoblastoid cell line (LCL)
Production of chimeric antigen receptor (CAR)-T cells for preclinical testing using non-viral transposon vectors and a lymphoblastoid cell line (LCL) Open
View article: Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52 bp deletion and the ASXL1 p.R693X mutation
Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52 bp deletion and the ASXL1 p.R693X mutation Open
View article: An Efficient Electroporation Protocol for the Genetic Modification of Mammalian Cells
An Efficient Electroporation Protocol for the Genetic Modification of Mammalian Cells Open
Genetic modification of cell lines and primary cells is an expensive and cumbersome approach, often involving the use of viral vectors. Electroporation using square-wave generating devices, like Lonza's Nucleofector, is a widely used optio…
View article: An efficient electroporation protocol for the genetic modification of mammalian cells
An efficient electroporation protocol for the genetic modification of mammalian cells Open
Genetic modification of cell lines and primary cells is an expensive and cumbersome approach, often involving the use of viral vectors. Electroporation using square wave generating devices, like Lonza´s Nucleofector, is a widely used optio…
View article: IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering
IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering Open
CD4 T cell activation and differentiation mechanisms constitute a complex and intricate signaling network involving several regulatory proteins. IRF2BP2 is a transcriptional repressor that is involved in gene-expression regulation in very …
View article: Ectopic expression of miR-182 in chimeric antigen receptor-modified T cells
Ectopic expression of miR-182 in chimeric antigen receptor-modified T cells Open