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View article: Perfect Secrecy in the Wild: A Characterization
Perfect Secrecy in the Wild: A Characterization Open
Alice wishes to reveal the state $X$ to Bob, if he knows some other information $Y$ also known to her. If Bob does not, she wishes to reveal nothing about $X$ at all. When can Alice accomplish this? We provide a simple necessary and suffic…
View article: Depressão e diabetes mellitus tipo 2
Depressão e diabetes mellitus tipo 2 Open
Diabéticos têm maior risco de desenvolver depressão, e, por outro lado, diabetes pode aumentar risco de ocorrer depressão. Inflamação crônica, alterações que afetam o eixo hipotálamo-hipotálamo-adrenal (HPA), desequilíbrio hormonal e dieta…
View article: Perfect Secrecy in the Wild: A Characterization
Perfect Secrecy in the Wild: A Characterization Open
View article: Twenty-five years of natural products research in NuBBE
Twenty-five years of natural products research in NuBBE Open
The richness of Brazilian biodiversity translates into a valuable collection of molecules with biological properties that range from ecological functions to pharmacological properties. For over 25 years, the Nucleus of Bioassays, Biosynthe…
View article: Phenylalanine ammonia lyase: new insights from Piperaceae species
Phenylalanine ammonia lyase: new insights from Piperaceae species Open
The enzyme PAL (phenylalanine ammonia lyase) mediates the key entry point to the general phenylpropanoid pathway, which is involved in the lignification process and in the formation of a myriad of secondary compounds in plants that show a …
View article: New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius
New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius Open
As part of our continuing efforts to discover new bioactive compounds from endophytic fungal sources, we have investigated the extract of the Paraphaeosphaeria sporulosa F03 strain. The study led to the isolation of four new 3-methyl-isoqu…
View article: Amino acids L-phenylalanine and L-lysine involvement in trans and cis piperamides biosynthesis in two Piper species
Amino acids L-phenylalanine and L-lysine involvement in trans and cis piperamides biosynthesis in two Piper species Open
Several Piper species accumulate piperamides as secondary metabolites, and although they have relevant biological importance, many details of their biosynthetic pathways have not yet been described experimentally. Experiments involving enz…
View article: The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity
The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity Open
Friedelin, a pentacyclic triterpene found in the leaves of the Celastraceae species, demonstrates numerous biological activities and is a precursor of quinonemethide triterpenes, which are promising antitumoral agents. Friedelin is biosynt…
View article: Anthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus
Anthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus Open
View article: Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry
Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry Open
Maytenus ilicifolia (Celastraceae) is a medicinal plant that is native to southern Brazil and is popularly known as “espinheira-santa”. From a biosynthesis perspective, this species accumulates quinonemethide triterpenes and sesquiterpene …
View article: MULHERES NA CIÊNCIA: UM OLHAR PARA A PÓS-GRADUAÇÃO E A ÁREA DE MATERIAIS
MULHERES NA CIÊNCIA: UM OLHAR PARA A PÓS-GRADUAÇÃO E A ÁREA DE MATERIAIS Open
RESUMOAs mulheres têm demonstrado intrínseca capacidade de liderança e, muitas vezes, são sub-representadas. A presença das mulheres na ciência pode ser ilustrada pelos dados do Prêmio Nobel. A proporção de laureadas mostra a intrínseca re…
View article: Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry
Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry Open
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View article: Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots
Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots Open
View article: CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway
CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway Open
The native Brazilian plant Maytenus ilicifolia accumulates a set of quinone methide triterpenoids with important pharmacological properties, of which maytenin, pristimerin and celastrol accumulate exclusively in the root bark of this medic…
View article: Antibacterial activity of prenylated benzopyrans from <i>Peperomia obtusifolia</i> (Piperaceae)
Antibacterial activity of prenylated benzopyrans from <i>Peperomia obtusifolia</i> (Piperaceae) Open
Peperomia obtusifolia is a herbaceous perennial plant native to the Americas reported as a traditional medicine to treat snake bites and as a skin cleanser. The bioassay-guided fractionation of crude extracts from aerial parts of
View article: Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)
Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) Open
View article: Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection
Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection Open
Biodiversity is key for maintenance of life and source of richness. Nevertheless, concepts such as phenotype expression are also pivotal to understand how chemical diversity varies in a living organism. Sesquiterpene pyridine alkaloids (SP…
View article: Crude leaf extracts of Piperaceae species downmodulate inflammatory responses by human monocytes
Crude leaf extracts of Piperaceae species downmodulate inflammatory responses by human monocytes Open
In this study, we aimed to evaluate the immunomodulatory effects of crude leaf extracts from Piper gaudichaudianum Kunth, P. arboreum Aub., P. umbellata L., P. fuligineum Kunth, and Peperomia obtusifolia A. Dietr. on an in vitro model of i…
View article: Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Trypanosoma cruzi: analysis of two different strains after piplartine treatment Open
View article: Screening of 2A peptides for polycistronic gene expression in yeast
Screening of 2A peptides for polycistronic gene expression in yeast Open
A complexity of pathway expression in yeast compared to prokaryotes is the need for separate promoters and terminators for each gene expressed. Single transcript expression and separated protein production is possible via the use of 2A vir…
View article: Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms
Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms Open
Triterpenes are interesting compounds because they play an important role in cell homeostasis and a wide variety exhibiting defense functions is produced by plant secondary metabolism. Those same plant secondary metabolites also exhibit bi…
View article: Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasome
Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasome Open
View article: Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum
Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum Open
Piper gaudichaudianum Kunth (Piperaceae) accumulates gaudichaudianic acid, a prenylated benzopyran, as its major component. Interestingly, this trypanocidal compound occurs as a racemic mixture. Herein, transcriptomic investigations of Pip…
View article: Proteomic profile of Piper tuberculatum (Piperaceae)
Proteomic profile of Piper tuberculatum (Piperaceae) Open
Piper tuberculatum (Piperaceae) is a species that accumulates especially amides as secondary metabolites and several biological activities was previously reported. In this article, we report a proteomic study of P. tuberculatum. Bidimensio…
View article: Instructions for Authors
Instructions for Authors Open
View article: Proteomic profile of Piper tuberculatum (Piperaceae)
Proteomic profile of Piper tuberculatum (Piperaceae) Open
Piper tuberculatum (Piperaceae) is a species that accumulates especially amides as secondary metabolites and several biological activities was previously reported. In this article, we report a proteomic study of P. tuberculatum. Bidimensio…
View article: Sistema Nacional de Pós-Graduação e a Área de Química na CAPES
Sistema Nacional de Pós-Graduação e a Área de Química na CAPES Open
The Coordination for the Improvement of High Education Personnel (CAPES), the Brazilian federal agency for graduate programs, plays a fundamental role for the expansion and consolidation of the National Postgraduate System (SNPG) and the e…
View article: Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae)
Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae) Open
View article: Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes
Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes Open
View article: The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in <i>Peperomia obtusifolia</i>
The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in <i>Peperomia obtusifolia</i> Open
Peperomia obtusifolia, an ornamental plant from the Piperaceae family, accumulates a series of secondary metabolites with interesting biological properties. From a biosynthesis standpoint, this species produces several benzopyrans derived …