Mazhar Pasha
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View article: Redox changes and cellular senescence in Alzheimer's disease
Redox changes and cellular senescence in Alzheimer's disease Open
View article: The effect of tauroursodeoxycholic Acid (TUDCA) treatment on placental endoplasmic reticulum (ER) stress in a rat model of advanced maternal age
The effect of tauroursodeoxycholic Acid (TUDCA) treatment on placental endoplasmic reticulum (ER) stress in a rat model of advanced maternal age Open
Advanced maternal age (≥35 years) is associated with an increased risk of pregnancy complications such as fetal growth restriction and preeclampsia. We previously demonstrated poor pregnancy outcomes (reduced fetal body weight), altered va…
View article: The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring
The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring Open
Prenatal hypoxia predisposes the offspring to the development of cardiovascular (CV) dysfunction in adult life. Using a rat model, we assessed the effect of prenatal hypoxia on vasoconstrictive and vasodilative mechanisms in left anterior …
View article: Advanced Maternal Age Impairs Uterine Artery Adaptations to Pregnancy in Rats
Advanced Maternal Age Impairs Uterine Artery Adaptations to Pregnancy in Rats Open
Advanced maternal age (≥35 years) is associated with pregnancy complications. Aging impairs vascular reactivity and increases vascular stiffness. We hypothesized that uterine artery adaptations to pregnancy are impaired with advanced age. …
View article: The Effect of Tauroursodeoxycholic Acid (TUDCA) Treatment on Pregnancy Outcomes and Vascular Function in a Rat Model of Advanced Maternal Age
The Effect of Tauroursodeoxycholic Acid (TUDCA) Treatment on Pregnancy Outcomes and Vascular Function in a Rat Model of Advanced Maternal Age Open
Advanced maternal age (≥35 years) increases the risk of vascular complications in pregnancy that can result in fetal growth restriction and preeclampsia. Endoplasmic reticulum (ER) stress has been linked to adverse pregnancy outcomes in th…
View article: Altered Vascular Adaptations to Pregnancy in a Rat Model of Advanced Maternal Age
Altered Vascular Adaptations to Pregnancy in a Rat Model of Advanced Maternal Age Open
Advanced maternal age (≥35 years old) increases the risk of pregnancy complications such as preeclampsia and fetal growth restriction. We previously demonstrated vascular dysfunction and abnormal pregnancy outcomes in a rat model of advanc…
View article: Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress‑impaired endothelial cell angiogenic response: A critical role for cell survival
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress‑impaired endothelial cell angiogenic response: A critical role for cell survival Open
Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is critically located on…
View article: Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival
Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival Open
Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly released from …
View article: Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury
Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury Open
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. Activation of signaling pathways such as the mammalian target of rapamycin (mTOR), extracellular signal-regulated kinases (ERK), endoplasmic reticulum …
View article: Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines
Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines Open
Clear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau (VHL) tumor-suppressor gene and the resultant overexpression of hypoxia-inducible factor…
View article: Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases Open
Sestrin2 (SESN2), a highly conserved stress‐inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, endoplasmic ret…