Explanipedia

Training General Movements Classifiers with Global Labels Offers Insights on Sub-movement Quality Open

Manpreet Kaur, Hamid Abbasi, Sîan A. Williams, Malcolm Battin, Thor F. Besier , et al. · 2025

The role of muscle synergies and task constraints on upper limb motor impairment after stroke Open

Pablo Ortega-Auriol, Winston D. Byblow, April Ren, Thor F. Besier, Angus J. C. McMorland · 2025

Effect of surface electromyography normalisation methods over gait muscle synergies Open

Pablo Ortega-Auriol, Thor F. Besier, Angus J. C. McMorland · 2024

This study investigates the effect of different normalisation methods on muscle synergy extraction from EMG data collected while walking in typically developing young people. Six methods were evaluated: Raw, Within-Trial Maximum, Inter-Tri…

Circuits in the motor cortex explain oscillatory responses to transcranial magnetic stimulation Open

Lysea Haggie, Thor F. Besier, Angus J. C. McMorland · 2023

Transcranial magnetic stimulation (TMS) is a popular method used to investigate brain function. Stimulation over the motor cortex evokes muscle contractions known as motor evoked potentials (MEPs) and also high-frequency volleys of electri…

Deep-learning-based markerless tracking of distal anatomical landmarks in clinically recorded videos for assessing infant movement patterns associated with neurodevelopmental status Open

Hamid Abbasi, Sarah R. Mollet, Sîan A. Williams, Malcolm Battin, Thor F. Besier , et al. · 2023

Abnormal patterns in infants' General Movements (GMs) are robust clinical indicators for the progression of neurodevelopmental disorders, including cerebral palsy. Availability of automated platforms for General Movements Assessments (GMA)…

Deep-learning for automated markerless tracking of infants general movements Open

Hamid Abbasi, Sarah R. Mollet, Shirley Williams, Laurence A. Gan Lim, Malcolm Battin , et al. · 2023

The presence of abnormal infant General Movements (GMs) is a strong predictor of progressive neurodevelopmental disorders, including cerebral palsy (CP). Automation of the assessment will overcome scalability barriers that limit its delive…

Muscle synergies are associated with intermuscular coherence and cortico-synergy coherence in an isometric upper limb task Open

Pablo Ortega-Auriol, Winston D. Byblow, Thor F. Besier, Angus J. C. McMorland · 2023

Modelling Spontaneous Firing Activity of the Motor Cortex in a Spiking Neural Network with Random and Local Connectivity Open

Lysea Haggie, Thor F. Besier, Angus J. C. McMorland · 2023

Computational models of cortical activity provide insight into the mechanisms of higher-order processing in the human brain including planning, perception and the control of movement. Activity in the cortex is ongoing even in the absence o…

Circuits in the Motor Cortex Explain Oscillatory Responses to Transcranial Magnetic Stimulation Open

Lysea Haggie, Thor F. Besier, Angus J. C. McMorland · 2023

Transcranial Magnetic Stimulation (TMS) is a popular method used to investigate brain function. Stimulation over the motor cortex evokes muscle contractions known as motor evoked potentials (MEPs) and also high frequency volleys of electri…

Modelling Spontaneous Firing Activity of the Motor Cortex in a Spiking Neural Network with Random and Local Connectivity Open

Lysea Haggie, Thor F. Besier, Angus J. C. McMorland · 2023

Computational models of cortical activity can provide insight into the mechanisms of higher-order processing in the human brain including planning, perception and the control of movement. Activity in the cortex is ongoing even in the absen…

Linking cortex and contraction—Integrating models along the corticomuscular pathway Open

Lysea Haggie, Laura Schmid, Oliver Röhrle, Thor F. Besier, Angus J. C. McMorland , et al. · 2023

Computational models of the neuromusculoskeletal system provide a deterministic approach to investigate input-output relationships in the human motor system. Neuromusculoskeletal models are typically used to estimate muscle activations and…

Modelling Spontaneous Firing Activity of the Motor Cortex in a Spiking Neural Network with Random and Local Connectivity Open

Lysea Haggie, Thor F. Besier, Angus J. C. McMorland · 2022

Computational models of cortical activity can provide in-sight into the mechanisms of higher-order processing in the human brain including planning, perception and the control of movement. Activity in the cortex is ongoing even in the abse…

Deep-Learning for Automated Markerless Tracking of Infants General Movements Open

Hamid Abbasi, Sarah R. Mollet, Sîan A. Williams, Laurence A. Gan Lim, Malcolm Battin , et al. · 2022

The presence of abnormal infant General Movements (GMs) is a strong predictor of progressive neurodevelopmental disorders, including cerebral palsy (CP). Automation of the assessment will overcome scalability barriers that limit its delive…

Muscle synergies are associated with intermuscular coherence in an isometric upper limb task Open

Pablo Ortega-Auriol, Winston D. Byblow, Angus J. C. McMorland · 2019

To elucidate the underlying physiological mechanism of muscle synergies, we investigated the functional corticomuscular and intermuscular binding during an isometric upper limb task in 14 healthy participants. Cortical activity was recorde…

Effects of arm weight support on neuromuscular activation during reaching in chronic stroke patients Open

Keith D. Runnalls, Pablo Ortega-Auriol, Angus J. C. McMorland, J. Greg Anson, Winston D. Byblow · 2019

To better understand how arm weight support (WS) can be used to alleviate upper limb impairment after stroke, we investigated the effects of WS on muscle activity, muscle synergy expression, and corticomotor excitability (CME) in 13 chroni…

Fatigue Influences the Recruitment, but Not Structure, of Muscle Synergies Open

Pablo Ortega-Auriol, Thor F. Besier, Winston D. Byblow, Angus J. C. McMorland · 2018

The development of fatigue elicits multiple adaptations from the neuromuscular system. Muscle synergies are common patterns of neuromuscular activation that have been proposed as the building blocks of human movement. We wanted to identify…

Fatigue influences the recruitment, but not structure, of muscle synergies Open

Pablo Ortega-Auriol, Thor F. Besier, Winston D. Byblow, Angus J. C. McMorland · 2018

The development of fatigue elicits multiple adaptations from the neuromuscular system. Muscle synergies are common patterns of neuromuscular activation that have been proposed as the building blocks of human movement. We wanted to identify…

Temporally Segmented Directionality in the Motor Cortex Open

Steven B. Suway, Josue Orellana, Angus J. C. McMorland, George W. Fraser, Z Liu , et al. · 2017

Developing models of the dynamic and complex patterns of information processing that take place during behavior is a major thrust of systems neuroscience. An underlying assumption of many models is that the same set of rules applies across…

An Activation Threshold Model for Response Inhibition Open

Hayley J. MacDonald, Angus J. C. McMorland, Cathy M. Stinear, James P. Coxon, Winston D. Byblow · 2017

Reactive response inhibition (RI) is the cancellation of a prepared response when it is no longer appropriate. Selectivity of RI can be examined by cueing the cancellation of one component of a prepared multi-component response. This subst…

A Neuroanatomical Framework for Upper Limb Synergies after Stroke Open

Angus J. C. McMorland, Keith D. Runnalls, Winston D. Byblow · 2015

Muscle synergies describe common patterns of co- or reciprocal activation that occur during movement. After stroke, these synergies change, often in stereotypical ways. The mechanism underlying this change reflects damage to key motor path…

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