Mahmood Khan
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View article: Targeting MERTK tyrosine kinase: Virtual screening and molecular dynamics insights for anti-cancer drug development
Targeting MERTK tyrosine kinase: Virtual screening and molecular dynamics insights for anti-cancer drug development Open
Global public health facing serious challenges due to the incidence of cancer and the growth of treatment resistance. Mer-tyrosine kinase plays a crucial role in cell biology and correlated with many cancers such as Epithelial ovarian canc…
View article: Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition
Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition Open
Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) is frequently observed in various cancers and promotes tumorigenesis by activating the PI3K-AKT pathway. However, the effectiveness of therapies targeting this pathway is l…
View article: Roles of exogenous bioactive peptides in obesity and obesity-related diseases: A review
Roles of exogenous bioactive peptides in obesity and obesity-related diseases: A review Open
Exogenous bioactive peptides (eBAPs) are short amino acid peptides that are released through enzymatic hydrolysis. These peptides are derived from various sources such as oysters, soybeans, eggs, and other foods. The eBAPs exhibit a range …
View article: Initial experience of cardiac <scp>T</scp> <sub>1</sub> ρ mapping at 0.55 <scp>T</scp> : Continuous wave versus adiabatic spin‐lock preparation pulses
Initial experience of cardiac <span>T</span> <sub>1</sub> ρ mapping at 0.55 <span>T</span> : Continuous wave versus adiabatic spin‐lock preparation pulses Open
Purpose To propose and validate a cardiac T 1 ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods The proposed 2D sequence acquires four single‐shot balanced SSFP readout images w…
View article: Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition
Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition Open
Loss of the tumor suppressor PTEN is frequently observed in various cancers and promotes tumorigenesis by activating the PI3K-AKT pathway. However, the effectiveness of therapies targeting this pathway is limited by complex signaling cross…
View article: Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity
Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity Open
Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic a…
View article: Pre- and post-contrast joint T1/T2 mapping at 0.55T for detection of myocardial infarction: Validation in porcine models
Pre- and post-contrast joint T1/T2 mapping at 0.55T for detection of myocardial infarction: Validation in porcine models Open
View article: Novel iNAV-based 3D whole heart late gadolinium enhancement low-field (0.55T) CMR – an investigation in a pig model
Novel iNAV-based 3D whole heart late gadolinium enhancement low-field (0.55T) CMR – an investigation in a pig model Open
View article: <i>Pseudomonas aeruginosa-</i>mediated cardiac dysfunction is driven by extracellular vesicles released during infection
<i>Pseudomonas aeruginosa-</i>mediated cardiac dysfunction is driven by extracellular vesicles released during infection Open
Pseudomonas aeruginosa (P.a.) is a gram-negative, opportunistic bacterium abundantly present in the environment. Often P.a. infections cause severe pneumonia, if left untreated. Surprisingly, up to 30% of patients admitted to the hospital …
View article: Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome
Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome Open
View article: Fabrication and Optimization of Poly(ε-caprolactone) Microspheres Loaded with S-Nitroso-N-Acetylpenicillamine for Nitric Oxide Delivery
Fabrication and Optimization of Poly(ε-caprolactone) Microspheres Loaded with S-Nitroso-N-Acetylpenicillamine for Nitric Oxide Delivery Open
Heart disease is one of the leading causes of death in the United States and throughout the world. While there are different techniques for reducing or preventing the impact of heart disease, nitric oxide (NO) is administered as nitroglyce…
View article: Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells
Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells Open
The development of epithelial-to-mesenchymal transition (EMT) like features is emerging as a critical factor involved in the pathogenesis of acute myeloid leukaemia (AML). However, the extracellular signals and the signalling pathways in A…
View article: Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes
Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes Open
Myocardial Infarction (MI) occurs due to a blockage in the coronary artery resulting in ischemia and necrosis of cardiomyocytes in the left ventricular heart muscle. The dying cardiac tissue is replaced with fibrous scar tissue, causing a …
View article: Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Our group and others have determined that immune effector cells from patients with advanced cancers exhibit reduced activation of IFN signaling pathways. We hypothesized that increases in immune regulatory cells termed myeloid-derived supp…
View article: Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 4 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 2 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Data from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Our group and others have determined that immune effector cells from patients with advanced cancers exhibit reduced activation of IFN signaling pathways. We hypothesized that increases in immune regulatory cells termed myeloid-derived supp…
View article: Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 1 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure Legends 1-6 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 3 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Open
Supplementary Figure 5 from Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
View article: Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications
Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications Open
Background Contemporary advances in low-field magnetic resonance imaging systems can potentially widen access to cardiovascular magnetic resonance (CMR) imaging. We present our initial experience in building a comprehensive CMR protocol on…