Douglas L. Mann
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View article: Comparative analysis of isoproterenol- and lipopolysaccharide-mediated cytoprotective responses in the heart
Comparative analysis of isoproterenol- and lipopolysaccharide-mediated cytoprotective responses in the heart Open
This study shows that isoproterenol and lipopolysaccharide establish cardioprotection through the activation of distinct upstream signaling and cell-cell communication networks that converge on interferon signaling in the heart. Viewed tog…
View article: Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy
Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy Open
Aims Although the ability of the heart to adapt to environmental stress has been studied extensively, the molecular and cellular mechanisms responsible for cardioprotection are not yet fully understood. In this study, we sought to elucidat…
View article: Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery
Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery Open
Despite advances in disease treatment, our understanding of how damaged organs recover and the mechanisms governing this process remain poorly defined. Here, we mapped the transcriptional and regulatory landscape of human cardiac recovery …
View article: Burst steroid therapy and quality of life in patients with acute heart failure: Insights from the CORTAHF trial
Burst steroid therapy and quality of life in patients with acute heart failure: Insights from the CORTAHF trial Open
Aims Patients hospitalized with acute heart failure (AHF) treated with a 7 day prednisone course in the CORTAHF pilot trial had a greater improvement in health‐related quality of life (QoL) at Day 7 in both the overall population and in pa…
View article: Immunogenicity, Reactogenicity, and Safety of a Pentavalent Meningococcal ABCWY Vaccine in Adolescents and Young Adults Who Had Previously Received a Meningococcal ACWY Vaccine: A Phase 3, Randomized Controlled Clinical Study
Immunogenicity, Reactogenicity, and Safety of a Pentavalent Meningococcal ABCWY Vaccine in Adolescents and Young Adults Who Had Previously Received a Meningococcal ACWY Vaccine: A Phase 3, Randomized Controlled Clinical Study Open
Background A MenABCWY vaccine containing 4CMenB and MenACWY-CRM vaccine components has been developed to protect against the 5 meningococcal serogroups that cause most invasive disease cases. Methods In this phase 3 study, healthy particip…
View article: Association Between Body Mass Index and Clinical Outcomes in Patients with Acute Myocardial Infarction and Reduced Systolic Function: Analysis of PARADISE-MI Trial Data
Association Between Body Mass Index and Clinical Outcomes in Patients with Acute Myocardial Infarction and Reduced Systolic Function: Analysis of PARADISE-MI Trial Data Open
Aims The relationship between body mass index (BMI) and clinical outcomes in patients with cardiovascular disease, including acute heart failure (AHF) and acute myocardial infarction (AMI), remains debated. This study investigates the asso…
View article: Thrombotic, Cardiovascular, and Microvascular Complications of Myeloproliferative Neoplasms and Clonal Hematopoiesis (CHIP): A Narrative Review
Thrombotic, Cardiovascular, and Microvascular Complications of Myeloproliferative Neoplasms and Clonal Hematopoiesis (CHIP): A Narrative Review Open
The most common causes of morbidity and mortality in the myeloproliferative neoplasms (MPNs), with the exception of myelofibrosis, are venous and arterial thrombosis, as well as more recently discovered cardiovascular disease (CVD). Clonal…