Meaghan Castledine
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View article: Corrigendum: Bacteria–phage (co)evolution is constrained in a synthetic community across multiple bacteria–phage pairs
Corrigendum: Bacteria–phage (co)evolution is constrained in a synthetic community across multiple bacteria–phage pairs Open
View article: Community Complexity Does Not Weaken Pairwise Coevolution in a Soil Bacterial Community
Community Complexity Does Not Weaken Pairwise Coevolution in a Soil Bacterial Community Open
Exploitative interactions, such as predator–prey and host–parasite interactions, are ubiquitous in microbial communities. These interactions shape community density and composition, imposing strong selection on members to evolve countermea…
View article: Community complexity does not weaken pairwise coevolution in a soil bacterial community
Community complexity does not weaken pairwise coevolution in a soil bacterial community Open
Exploitative interactions, such as predator-prey and host-parasite interactions, are ubiquitous in microbial communities. These interactions shape community density and composition, imposing strong selection on members to evolve countermea…
View article: Bacteria–phage (co)evolution is constrained in a synthetic community across multiple bacteria–phage pairs
Bacteria–phage (co)evolution is constrained in a synthetic community across multiple bacteria–phage pairs Open
Bacteriophages can be important drivers of bacterial densities and, therefore, microbial community composition and function. These ecological interactions are likely to be greatly affected by evolutionary dynamics because bacteria can rapi…
View article: Predicting clinical phage therapy outcomes <i>in vitro</i> : results using mixed versus single isolates from an MRSA case study
Predicting clinical phage therapy outcomes <i>in vitro</i> : results using mixed versus single isolates from an MRSA case study Open
Aims In phage therapy case studies, 1–3 bacteria isolates are typically tested against phages (phagogram). However, as bacteria populations differ in their susceptibility to phages and antibiotics, the strains selected may not represent ho…
View article: Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance
Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance Open
Phage therapy, the use of viruses that infect bacteria (bacteriophages), is a promising complement to antibiotics during the antimicrobial resistance crisis, but treatment success is very variable. Evolution of bacterial resistance to bact…
View article: Predicting clinical phage therapy outcomes <i>in vitro</i> : results using mixed versus single isolates from an MRSA case study
Predicting clinical phage therapy outcomes <i>in vitro</i> : results using mixed versus single isolates from an MRSA case study Open
Aims In phage therapy case studies, 1-3 bacteria isolates are typically tested against phages (phagogram). However, as bacteria populations differ in their susceptibility to phages and antibiotics, the strains selected may not represent ho…
View article: Microbial community structure is affected by phage-resistance associated increases in host density
Microbial community structure is affected by phage-resistance associated increases in host density Open
Lytic bacteriophages (‘phages’) can limit bacterial densities and shape community structure, either directly through lysis or indirectly through costs to resistance. However, phages have also been reported to have no, and in some cases eve…
View article: Corrigendum: Characterizing a stable five-species microbial community for use in experimental evolution and ecology
Corrigendum: Characterizing a stable five-species microbial community for use in experimental evolution and ecology Open
View article: Estimates of microbial community stability using relative invader growth rates are robust across levels of invader species richness
Estimates of microbial community stability using relative invader growth rates are robust across levels of invader species richness Open
A key feature of natural communities is that the species within them stably coexist. A common metric used to test community stability is the ability of each species to invade from rare. A potential issue with this measurement is that singl…
View article: Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs
Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs Open
Bacteriophages can be important drivers of bacterial densities, and therefore microbial community composition and function. These ecological interactions are likely to be greatly affected by evolutionary dynamics, because bacteria can rapi…
View article: Characterizing a stable five-species microbial community for use in experimental evolution and ecology
Characterizing a stable five-species microbial community for use in experimental evolution and ecology Open
A corrigendum of this article has been published full details can be found at 10.1099/mic.0.001528 Model microbial communities are regularly used to test ecological and evolutionary theory as they are easy to manipulate and have fast gener…
View article: Estimates of community stability using the invasion criterion are robust across levels of invader species richness
Estimates of community stability using the invasion criterion are robust across levels of invader species richness Open
A key feature of natural communities is that the species within them stably coexist. A common metric used to test community stability is measuring the ability of each species to recover from rare. Here, each species is assumed to have nega…
View article: Critically evaluating the relative importance of phage in shaping microbial community composition
Critically evaluating the relative importance of phage in shaping microbial community composition Open
The ubiquity of bacteriophages (phages) and the major evolutionary and ecological impacts they can have on their microbial hosts has resulted in phages often cited as key drivers shaping microbial community composition (the relative abunda…
View article: Microbial community structure is affected by phage-resistance associated increases in host density
Microbial community structure is affected by phage-resistance associated increases in host density Open
Lytic bacteriophages (‘phages’) can limit bacterial densities and shape community structure, either directly through lysis or indirectly through costs to resistance. However, phages have also been reported to have no, and in some cases eve…
View article: Sexual conflict over sex—an underappreciated consequence of childbirth?
Sexual conflict over sex—an underappreciated consequence of childbirth? Open
Many postpartum women experience sexual dysfunction, characterised by reduced sexual motivation and libido, and pain during intercourse. Menstruation is also suppressed in breastfeeding women (lactational amenorrhoea). Lactational amenorrh…
View article: Antagonistic Mobile Genetic Elements Can Counteract Each Other’s Effects on Microbial Community Composition
Antagonistic Mobile Genetic Elements Can Counteract Each Other’s Effects on Microbial Community Composition Open
While bacteriophages (“phages”) are often cited as some of the key drivers of microbial diversity, evidence for this is greatly mixed. We demonstrate, in silico and experimentally, that the impact of phages, an example of a mobile genetic …
View article: Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networks
Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networks Open
Antimicrobial resistance (AMR) genes are often carried on broad host range plasmids, and the spread of AMR within microbial communities will therefore depend on the structure of bacteria–plasmid networks. Empirical and theoretical studies …
View article: Parallel phage resistance - virulence trade - offs during clinical phage therapy and in vitro
Parallel phage resistance - virulence trade - offs during clinical phage therapy and in vitro Open
With rising antibiotic resistance, modern medicine needs new approaches for tackling bacterial infections. Phage therapy uses the viruses of pathogenic bacteria to clear the infection. Unlike antibiotics, phage can evolve if bacteria becom…
View article: Greater Phage Genotypic Diversity Constrains Arms-Race Coevolution
Greater Phage Genotypic Diversity Constrains Arms-Race Coevolution Open
Antagonistic coevolution between hosts and parasites, the reciprocal evolution of host resistance and parasite infectivity, has important implications in ecology and evolution. The dynamics of coevolution—notably whether host or parasite h…
View article: Author response: Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro
Author response: Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract With rising antibiotic…
View article: Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential? Open
View article: Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks
Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks Open
International audience
View article: Parallel evolution of phage resistance - virulence trade - offs during <i>in vitro</i> and nasal <i>Pseudomonas aeruginosa</i> phage treatment
Parallel evolution of phage resistance - virulence trade - offs during <i>in vitro</i> and nasal <i>Pseudomonas aeruginosa</i> phage treatment Open
With rising antibiotic resistance, there has been increasing interest in treating pathogenic bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at which bacteria can evolve resistance. Negative effect…
View article: Interspecific Niche Competition Increases Morphological Diversity in Multi-Species Microbial Communities
Interspecific Niche Competition Increases Morphological Diversity in Multi-Species Microbial Communities Open
Intraspecific competition for limited niches has been recognized as a driving force for adaptive radiation, but results for the role of interspecific competition have been mixed. Here, we report the adaptive diversification of the model ba…
View article: Interspecific niche competition increases morphological diversity in multi-species microbial communities
Interspecific niche competition increases morphological diversity in multi-species microbial communities Open
Data and code for the Adaptive diversification of Pseudomonas fluorescens in the presence of different numbers and combinations of four competing bacterial species.
View article: Experimental (co)evolution in a multi‐species microbial community results in local maladaptation
Experimental (co)evolution in a multi‐species microbial community results in local maladaptation Open
Interspecific coevolutionary interactions can result in rapid biotic adaptation, but most studies have focused only on species pairs. Here, we (co)evolved five microbial species in replicate polycultures and monocultures and quantified loc…
View article: Experimental (co)evolution in a multi-species microbial community results in local maladaptation
Experimental (co)evolution in a multi-species microbial community results in local maladaptation Open
Biotic adaptation dataset (Biotic_adaptation_060420.csv) describes net biotic adaptation of the five species of different evolutionary backgrounds. Res.id = evolution line of other community members not necessarily includ…
View article: Experimental multi-species microbial (co)evolution results in local maladaptation
Experimental multi-species microbial (co)evolution results in local maladaptation Open
Interspecific coevolutionary interactions can result in rapid biotic adaptation, but most studies have focused only on species pairs. Here, we (co)evolved five microbial species in replicate polycultures and monocultures and quantified loc…
View article: Characterising a stable five-species microbial community for use in experimental evolution and ecology
Characterising a stable five-species microbial community for use in experimental evolution and ecology Open
Model microbial communities are regularly used to test ecological and evolutionary theory as they are easy to manipulate and have fast generation times, allowing for large-scale, high throughput experiments. A key assumption for most model…