Meaghan M. Kennedy Ng
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View article: Reference-guided Genome Assembly of Long Non-coding RNA Transcripts Reveals Target Genes Associated With Crohn’s Disease
Reference-guided Genome Assembly of Long Non-coding RNA Transcripts Reveals Target Genes Associated With Crohn’s Disease Open
Crohn’s disease (CD) is highly heterogeneous in presentation and progression with no cure. Molecular phenotyping has been used to elucidate cellular and tissue-based alterations to characterize drivers and effects of disease. One currently…
View article: Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition
Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition Open
View article: eQTL in diseased colon tissue identifies novel target genes associated with IBD
eQTL in diseased colon tissue identifies novel target genes associated with IBD Open
Genome-wide association studies (GWAS) have identified over 300 loci associated with the inflammatory bowel diseases (IBD), but putative causal genes for most are unknown. We conducted the largest disease-focused expression quantitative tr…
View article: Post-operative Crohn’s Disease Recurrence and Infectious Complications: A Transcriptomic Analysis
Post-operative Crohn’s Disease Recurrence and Infectious Complications: A Transcriptomic Analysis Open
These findings shed light on the underlying biology of these outcomes and suggest potential biomarkers or therapeutic targets to reduce their occurrence. Further validation and multi-institutional studies are warranted to confirm these res…
View article: Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naive Adult Crohn's Disease Patients
Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naive Adult Crohn's Disease Patients Open
View article: Linking gene expression to clinical outcomes in pediatric Crohn's disease using machine learning
Linking gene expression to clinical outcomes in pediatric Crohn's disease using machine learning Open
View article: Linking gene expression to clinical outcomes in pediatric Crohn’s disease using machine learning
Linking gene expression to clinical outcomes in pediatric Crohn’s disease using machine learning Open
Pediatric Crohn’s disease (CD) is characterized by a severe disease course with frequent complications. We sought to apply machine learning-based models to predict risk of developing future complications in pediatric CD using ileal and col…
View article: Linking Gene Expression to Clinical Outcomes in Pediatric Crohn’s Disease Using Machine Learning
Linking Gene Expression to Clinical Outcomes in Pediatric Crohn’s Disease Using Machine Learning Open
Introduction Pediatric Crohn’s disease (CD) is the fastest growing age group and is characterized by frequent disease complications. We sought to analyze both ileal and colonic gene expression in a cohort of pediatric CD patients and apply…
View article: Spatial, transcriptomic and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition
Spatial, transcriptomic and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition Open
Summary Key mechanisms underlying chronic pain occur within the neural circuitry of the dorsal horn. Recent genome-wide association studies (GWAS) have identified genetic variants associated with the predisposition to chronic pain. However…
View article: BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis Open
Introduction In colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. It remains unknown if inhib…
View article: BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis Open
Introduction In colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. It remains unknown if inhib…
View article: Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease Patients
Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease Patients Open
View article: BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis Open
Introduction In colitis, macrophage functionality is altered compared to homeostatic conditions. Loss of IL-10 signaling results in an inappropriate and chronic inflammatory response to bacterial stimulation. It remains unknown if inhibiti…
View article: Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease
Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease Open
The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's disease (CD) and non-inflammatory bowel disease (non-IBD) controls. W…
View article: Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease
Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease Open
View article: Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn’s Disease
Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn’s Disease Open
Background and Aims: The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's disease (CD) and non-inflammatory bowel disease …
View article: Single-cell analysis of colonic epithelium reveals unexpected shifts in cellular composition and molecular phenotype in treatment-naïve adult Crohn’s disease
Single-cell analysis of colonic epithelium reveals unexpected shifts in cellular composition and molecular phenotype in treatment-naïve adult Crohn’s disease Open
The intestinal epithelial barrier is comprised of a monolayer of specialized intestinal epithelial cells (IECs) that are critical in maintaining gut mucosal homeostasis. Dysfunction within various IEC fractions can increase intestinal perm…
View article: A Comparison of the Cellular and Molecular Atlases of the Macaque and Mouse Dorsal Horns
A Comparison of the Cellular and Molecular Atlases of the Macaque and Mouse Dorsal Horns Open
View article: Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn’s disease
Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn’s disease Open
Background and Aims The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn’s disease (CD) and non-inflammatory bowel disease (…