Medha Priyadarshini
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View article: Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice
Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice Open
The global prevalence of Metabolic Dysfunction-Associated Steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates of obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are …
View article: Co-transplantation of mesenchymal stem cells and endothelial cells with islet grafts: A strategy to improve post-tx engraftment of pancreatic islets
Co-transplantation of mesenchymal stem cells and endothelial cells with islet grafts: A strategy to improve post-tx engraftment of pancreatic islets Open
Though islet transplantation is now being considered as a gold standard to cure type 1 diabetes in patients without the threat of unaware hypoglycemia and severe hypoglycemia episode, post-transplantation islet loss due to the loss of intr…
View article: Direct Epigenetic Reprogramming of Human Somatic Cells into Insulin-Producing Cell
Direct Epigenetic Reprogramming of Human Somatic Cells into Insulin-Producing Cell Open
Restoring insulin production through replacement of pancreatic β-cells presents a promising strategy for treating individuals with type 1 diabetes. However, current methods involving induced pluripotent stem cell differentiation are often …
View article: Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice
Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice Open
The global prevalence of Metabolic dysfunction-associated steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates of obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are …
View article: Prevalence of Comorbidities in Obstructive Sleep Apnea and Association with Disease Severity: A Descriptive Study
Prevalence of Comorbidities in Obstructive Sleep Apnea and Association with Disease Severity: A Descriptive Study Open
Background and objectives: Obstructive sleep apnea (OSA) is being progressively encountered in clinical practice due to the mounting epidemic of obesity, owing to an upsurge in sedentary habits in rural and urban populations. Sleep-related…
View article: β cell acetate production and release are negligible
β cell acetate production and release are negligible Open
Our findings do not substantiate the glucose-dependent release of acetate from pancreatic β cells, and therefore, invalidate the possibility of an autocrine inhibitory effect on glucose stimulated insulin secretion.
View article: Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice
Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice Open
Short-chain fatty acids (SCFAs) are key nutrients that play a diverse set of roles in physiological function, including regulating metabolic homeostasis. Generated through the fermentation of dietary fibers in the distal colon by the gut m…
View article: SAT073 β Cell FFA2 Deficiency Suppresses Multiple Low Dose Streptozotocin (MLDS) Induced Diabetes
SAT073 β Cell FFA2 Deficiency Suppresses Multiple Low Dose Streptozotocin (MLDS) Induced Diabetes Open
Disclosure: K. Xu: None. M. Priyadarshini: None. P. Kumar: None. H.M. Electricwala: None. B.S. Prabhakar: None. B.T. Layden: None. Gut microbiome is recently recognized environmental factor in pathogenesis of type 1 diabetes (T1D). Reduced…
View article: FRI013 Free Fatty Acid Receptors 2 And 3 Mediate The Beneficial Effects Of Fiber
FRI013 Free Fatty Acid Receptors 2 And 3 Mediate The Beneficial Effects Of Fiber Open
Disclosure: N.S. Pandya: None. M. Priyadarshini: None. B.T. Layden: None. The Gut Microbiome (GM) is a key player in whole body metabolism. Microbial dysregulation and dysbiosis have been linked to multiple pathologies including obesity an…
View article: The future treatment for type 1 diabetes: Pig islet- or stem cell-derived β cells?
The future treatment for type 1 diabetes: Pig islet- or stem cell-derived β cells? Open
Replacement of β cells is only a curative approach for type 1 diabetes (T1D) patients to avoid the threat of iatrogenic hypoglycemia. In this pursuit, islet allotransplantation under Edmonton’s protocol emerged as a medical miracle to atta…
View article: MOMMI-MP: A Comprehensive Database for Integrated Analysis of Metabolic and Microbiome Profiling of Mouse Pregnancy
MOMMI-MP: A Comprehensive Database for Integrated Analysis of Metabolic and Microbiome Profiling of Mouse Pregnancy Open
Pregnancy is a dynamic state with multiple metabolic changes occurring including insulin resistance. Gestational diabetes mellitus (GDM), a form of diabetes that appears during pregnancy, develops if metabolic aberrations occur, in particu…
View article: OR23-4 Intestinal FFA2 and FFA3 Mediate Obesogenic Effects in Mice on a Western Diet
OR23-4 Intestinal FFA2 and FFA3 Mediate Obesogenic Effects in Mice on a Western Diet Open
Free fatty acid receptor 2 and free fatty acid receptor 3 (FFA2/3) are two highly similar G protein-coupled receptors belonging to the free fatty acid receptor family. Their ligands are short-chain fatty acids (SCFAs), which are key nutrie…
View article: Direct conversion of somatic cells into ‘insulin-producing-cells’ by user-defined multiplex-epigenetic-engineering vector (MEEV-β)
Direct conversion of somatic cells into ‘insulin-producing-cells’ by user-defined multiplex-epigenetic-engineering vector (MEEV-β) Open
We demonstrate here a single-step and user-friendly approach to generate insulin producing cells by gRNA driven specific-activation of PDX1, NKX6.1, MAFA, Insulin and Glut2 genes in somatic cells via multiplex-epigenetic-engineering-vector…
View article: Intestinal FFA3 mediates obesogenic effects in mice on a Western diet
Intestinal FFA3 mediates obesogenic effects in mice on a Western diet Open
Here, we generated a novel intestine-specific knockout mouse model for FFA3 (Vil-FFA3) and performed a comprehensive metabolic characterization of mice in response to an obesogenic challenge. We found that Vil-FFA3 mice fed with a Western …
View article: Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis
Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis Open
GM changes accompanying pregnancy shift IDO1-dependent tryptophan metabolism toward kynurenine production, intestinal inflammation, and gestational IR, a phenotype reversed by genetic deletion or inhibition of IDO1. (Gestational Gut Microb…
View article: The hexokinase “HKDC1” interaction with the mitochondria is essential for hepatocellular carcinoma progression
The hexokinase “HKDC1” interaction with the mitochondria is essential for hepatocellular carcinoma progression Open
Hepatocellular carcinoma (HCC) is a leading cause of death from cancer malignancies. Recently, hexokinase domain containing 1 (HKDC1), was shown to have significant overexpression in HCC compared to healthy tissue. Using in vitro and in vi…
View article: Gestational insulin resistance is mediated by the gut microbiome-indoleamine 2,3-dioxygenase axis
Gestational insulin resistance is mediated by the gut microbiome-indoleamine 2,3-dioxygenase axis Open
Background and aims Normal gestation involves reprogramming of maternal gut microbiome (GM) that may contribute to maternal metabolic changes by unclear mechanisms. This study aimed to understand the mechanistic underpinnings of GM – mater…
View article: Fiber Diet-Mediated Increases in Short Chain Fatty Acids Alleviate Western Diet Induced Metabolic Dysfunction
Fiber Diet-Mediated Increases in Short Chain Fatty Acids Alleviate Western Diet Induced Metabolic Dysfunction Open
OBJECTIVES: Short chain fatty acids (SCFAs), which are gut microbial fermentation byproducts with suggested positive health effects, have emerged as a therapeutic modality against metabolic diseases like obesity and type 2 diabetes. Alluri…
View article: FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology
FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology Open
The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important…
View article: Loss of Intestine-Specific FFA3 Has Protective Effects Against Diet-Induced Obesity and Hyperglycemia in Mice on a Western Diet
Loss of Intestine-Specific FFA3 Has Protective Effects Against Diet-Induced Obesity and Hyperglycemia in Mice on a Western Diet Open
Free fatty acid receptor 3 (FFA3) is a recently-deorphaned G protein-coupled receptor belonging to the free fatty acid receptor family. Its ligands are short-chain fatty acids (SCFAs), which are key nutrients that play a diverse role in ph…
View article: Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women
Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women Open
We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the …
View article: Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance
Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance Open
This study explored adipocytokine associations with acute and chronic hyperglycemia in African-American men (AAM). Fourteen adipocytokines were measured from men with normal glucose tolerance (NGT) or type 2 diabetes (T2D, drug-naïve MF(−)…
View article: Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance
Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance Open
Background: Adipocytokines are important in type 2 diabetes (T2D). This study explored adipocytokine associations with acute and chronic hyperglycemia in African American Men (AAM). Methods: Fourteen adipocytokines were measured (multiplex…
View article: Microbe‐Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury
Microbe‐Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury Open
Background Arterial restenosis after vascular surgery is a common cause of midterm restenosis and treatment failure. Herein, we aim to investigate the role of microbe‐derived butyrate, FFAR2 (free fatty acid receptor 2), and FFAR3 (free fa…
View article: Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress
Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress Open
The free fatty acid receptor 3 (FFA3) is a nutrient sensor of gut microbiota-generated nutrients, the short-chain fatty acids. Previously, we have shown that FFA3 is expressed in β-cells and inhibits islet insulin secretion ex vivo. Here, …
View article: Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy
Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy Open
Background: Intrinsically photosensitive retinal ganglion cells (ipRGCs) control non-visual light responses (e.g. pupillary light reflex and circadian entrainment). Patients with diabetic retinopathy (DR) show reduced ipRGC function, as in…