Meeki Lad
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View article: TMIC-115. Reversing glioblastoma-induced changes in bone marrow hematopoiesis slows tumor growth
TMIC-115. Reversing glioblastoma-induced changes in bone marrow hematopoiesis slows tumor growth Open
While the contribution and polarization of immune cell populations in glioblastoma has been well studied, the reciprocal effect of this malignancy on immune reservoirs remains less understood. To that end, we orthotopically implanted C57BL…
View article: Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum
Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum Open
Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms with complex biology underpinned by unresolved cellular origins, molecular heterogeneity, and microenvironment interactions. Here, we employ single-nuclei RNA-sequ…
View article: Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells
Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells Open
To identify new therapeutic targets that limit glioblastoma (GBM) invasion, we applied druggable-genome CRISPR screens to patient-derived GBM cells in micro-dissectible biomimetic 3D hydrogel platforms that permit separation and independen…
View article: TMIC-01. TARGETABLE GENE EXPRESSION CHANGES MEDIATE EXTRAVASATION OF BREAST CANCER CELLS FROM THE CIRCULATION AND LOCAL PROLIFERATION IN THE BRAIN
TMIC-01. TARGETABLE GENE EXPRESSION CHANGES MEDIATE EXTRAVASATION OF BREAST CANCER CELLS FROM THE CIRCULATION AND LOCAL PROLIFERATION IN THE BRAIN Open
As breast cancer migrates into the brain, it acquires distinct genomic, immunologic and phenotypic changes through interactions with the local microenvironment. We sought to determine how targetable gene expression changes mediate breast c…
View article: Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma
Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma Open
Glioblastoma (GBM) is the most lethal primary brain neoplasm due to its highly immunosuppressive microenvironment and resistance to conventional therapies. To overcome this challenge, we engineered a replicating retrovirus (RRV) to deliver…
View article: BSBM-03 TARGETABLE GENE EXPRESSION CHANGES MEDIATE EXTRAVASATION OF BREAST CANCER CELLS FROM THE CIRCULATION AND LOCAL PROLIFERATION IN THE BRAIN
BSBM-03 TARGETABLE GENE EXPRESSION CHANGES MEDIATE EXTRAVASATION OF BREAST CANCER CELLS FROM THE CIRCULATION AND LOCAL PROLIFERATION IN THE BRAIN Open
As breast cancer migrates into the brain, it acquires distinct genomic, immunologic and phenotypic changes through interactions with the local microenvironment. We sought to determine how targetable gene expression changes mediate breast c…
View article: Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations
Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations Open
While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial plat…
View article: TMIC-34. SKULL-DERIVED MYELOID CELLS AUGMENT T CELL RESPONSES AND SUPPRESS GLIOBLASTOMA GROWTH
TMIC-34. SKULL-DERIVED MYELOID CELLS AUGMENT T CELL RESPONSES AND SUPPRESS GLIOBLASTOMA GROWTH Open
While recent studies have implicated the skull marrow as a functional immune reservoir in CNS pathology, its contribution to malignancy remains unexplored. To that end, we transplanted fluorescently-labeled calvarial flaps into syngeneic g…
View article: TMET-22. MULTI-OMIC SCREENING OF INVASIVE GBM CELLS IN ENGINEERED BIOMATERIALS AND PATIENT BIOPSIES REVEALS TARGETABLE TRANSSULFURATION PATHWAY ALTERATIONS
TMET-22. MULTI-OMIC SCREENING OF INVASIVE GBM CELLS IN ENGINEERED BIOMATERIALS AND PATIENT BIOPSIES REVEALS TARGETABLE TRANSSULFURATION PATHWAY ALTERATIONS Open
While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial plat…
View article: Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow
Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow Open
SUMMARY Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that ‘hybrid’ neutrophils with dendritic features – including morphological complexity, expression of antigen presentation g…
View article: Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations
Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations Open
While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial plat…
View article: Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells
Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells Open
The pituitary gland is one of the most cellularly diverse regions of the brain. Recent advancements in transcriptomic biology, such as single-cell RNA sequencing, bring an unprecedented glimpse into the molecular composition of the pituita…
View article: Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment
Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment Open
Pituitary adenomas (PAs) have been shown to cause excess cardiovascular disease comorbidity and mortality. Cerebrovascular disease (CeVD) is a small subset of cardiovascular disease with high morbidity, and its risk in patients with pituit…
View article: TMIC-59. GLIOBLASTOMA INDUCES THE DIFFERENTIATION AND RECRUITMENT OF NON-CANONICAL ANTI-TUMORAL NEUTROPHILS FROM SKULL BONE MARROW
TMIC-59. GLIOBLASTOMA INDUCES THE DIFFERENTIATION AND RECRUITMENT OF NON-CANONICAL ANTI-TUMORAL NEUTROPHILS FROM SKULL BONE MARROW Open
The effects of tumor-associated neutrophils (TANs) on glioblastoma biology remain poorly understood. Flow cytometric analysis of 5 newly diagnosed glioblastoma fresh tissue specimens surprisingly revealed a high fraction (21.0-34.1%) of TA…
View article: Trends in Medicare Reimbursement for Body Contouring Surgeries from 2009 to 2018: What Does this Mean for the Massive Weight Loss Population?
Trends in Medicare Reimbursement for Body Contouring Surgeries from 2009 to 2018: What Does this Mean for the Massive Weight Loss Population? Open
PURPOSE: In the setting of the obesity epidemic, there is an increasing number of bariatric surgeries. These patients undergo massive weight loss (MWL) and often have excess skin, resulting in physiological and psychological symptoms. Rece…
View article: 15. Trends in Medicare Reimbursement for Body Contouring Surgeries from 2009-2018: What Does This Mean for the Massive Weight Loss Population?
15. Trends in Medicare Reimbursement for Body Contouring Surgeries from 2009-2018: What Does This Mean for the Massive Weight Loss Population? Open
Body: Background: In the setting of the obesity epidemic, there is an increasing number of bariatric surgeries. These patients undergo massive weight loss (MWL) and often have excess skin resulting in physiological and psychological sympto…
View article: Perceived involvement in health care decisions among US adults: Sociodemographic and medical condition correlates
Perceived involvement in health care decisions among US adults: Sociodemographic and medical condition correlates Open
Findings may inform future shared decision making interventions.
View article: Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons
Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons Open
Topoisomerase II poisons are one of the most common class of chemotherapeutics used in cancer. We show that glioblastoma (GBM), the most malignant of all primary brain tumors in adults is responsive to TOP2 poisons. To identify genes that …
View article: Mobile Phone Ownership, Health Apps, and Tablet Use in US Adults With a Self-Reported History of Hypertension: Cross-Sectional Study
Mobile Phone Ownership, Health Apps, and Tablet Use in US Adults With a Self-Reported History of Hypertension: Cross-Sectional Study Open
Despite the increasing use of smartphones, tablets, and health-related apps, these tools are used less among people with a self-reported history of hypertension. To reach the widest cross-section of patients, a mix of novel mHealth interve…