Meenal Shukla
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View article: HTRS2025.P2.96 Abstract of Distinction Glu92 Mutations in Activated Protein C Toggle Its Conformation between Biased Cytoprotective Signaling and Thrombin-like Disruptive Signaling Due to Different PAR1 Cleavages at Arg46 versus Arg41
HTRS2025.P2.96 Abstract of Distinction Glu92 Mutations in Activated Protein C Toggle Its Conformation between Biased Cytoprotective Signaling and Thrombin-like Disruptive Signaling Due to Different PAR1 Cleavages at Arg46 versus Arg41 Open
View article: Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid
Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid Open
Activated protein C (APC) is a pleiotropic plasma protease with diverse functions derived from its anticoagulant, anti-inflammatory, and cytoprotective activities. The selective uncoupling and/or modulation of these APC activities by antib…
View article: Selective modulation of activated protein C activities by a nonactive site–targeting nanobody library
Selective modulation of activated protein C activities by a nonactive site–targeting nanobody library Open
Activated protein C (APC) is a pleiotropic coagulation protease with anticoagulant, anti-inflammatory, and cytoprotective activities. Selective modulation of these APC activities contributes to our understanding of the regulation of these …
View article: Novel exomic rare variants associated with venous thrombosis
Novel exomic rare variants associated with venous thrombosis Open
Summary Exomic rare variant polymorphisms ( c . 300 000) were analysed in the Scripps Venous Thrombosis (VTE) registry (subjects aged <55 years). Besides coagulation factor V ( F5 ) single nucleotide polymorphisms (SNPs), family with seque…
View article: Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo
Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo Open
Objective: Cardiac myosin (CM) is structurally similar to skeletal muscle myosin, which has procoagulant activity. Here, we evaluated CM’s ex vivo, in vivo, and in vitro activities related to hemostasis and thrombosis. Approach and Results…
View article: Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis
Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis Open
High-molecular-weight kininogen (HK), together with factor XI, factor XII and prekallikrein, is part of the contact system that has proinflammatory, prothrombotic, and vasoactive properties. We hypothesized that HK plays a role in the host…
View article: Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis
Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis Open
Previous studies have demonstrated that cleaved high‐molecular‐weight kininogen (HKa) induces endothelial apoptosis and inhibits angiogenesis and have suggested that this occurs through inhibition of Src family kinases. This study assessed…
View article: Synthetic platelet (SynthoPlate) technology enhances hemostasis in both prophylactic and emergency administration in mouse models of bleeding
Synthetic platelet (SynthoPlate) technology enhances hemostasis in both prophylactic and emergency administration in mouse models of bleeding Open
Event Abstract Back to Event Synthetic platelet (SynthoPlate) technology enhances hemostasis in both prophylactic and emergency administration in mouse models of bleeding Christa Pawlowski1, Ujjal Didar Singh Sekhon1, Venkaiah Betapudi2, M…
View article: Light-Regulated Thyroid Hormone Signaling Is Required for Rod Photoreceptor Development in the Mouse Retina
Light-Regulated Thyroid Hormone Signaling Is Required for Rod Photoreceptor Development in the Mouse Retina Open
Our data demonstrate that light exposure during postnatal development is required for rod photoreceptor development and that this effect could be mediated by thyroid hormone signaling.