Meeryo Choe
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Author Swipe
View article: Single-Cell Heterogeneity of EGFR Pathway Is Linked to Unique Signatures of Drug Response and Malignancy in Patient Derived Glioblastoma Stem Cells
Single-Cell Heterogeneity of EGFR Pathway Is Linked to Unique Signatures of Drug Response and Malignancy in Patient Derived Glioblastoma Stem Cells Open
Accepted article withdrawn by publisher.
View article: The neurocognitive correlates of DTI indicators of white matter disorganization in pediatric moderate-to-severe traumatic brain injury
The neurocognitive correlates of DTI indicators of white matter disorganization in pediatric moderate-to-severe traumatic brain injury Open
Introduction Neuroimaging has expanded our understanding of pediatric brain disorders in which white matter organization and connectivity are crucial to functioning. Paralleling the known pathobiology of many neurodevelopmental disorders, …
View article: 68 The Impact of Pain Catastrophizing on Neuropsychological Performance in Youth with Persistent Post Concussive Symptoms
68 The Impact of Pain Catastrophizing on Neuropsychological Performance in Youth with Persistent Post Concussive Symptoms Open
Objective: Patients with persistent post-concussion symptoms (PPCS) experience prolonged recovery (e.g., headache, fatigue, or dizziness) lasting >2 months post injury. These symptoms are thought to be maintained by several biopsychosocial…
View article: CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol
CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol Open
Treatment of youth concussion during the acute phase continues to evolve, and this has led to the emergence of guidelines to direct care. While symptoms after concussion typically resolve in 14-28 days, a portion (∼20%) of adolescents endo…
View article: Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI
Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI Open
In survivors of moderate to severe traumatic brain injury (msTBI), affective disruptions often remain underdetected and undertreated, in part due to poor understanding of the underlying neural mechanisms. We hypothesized that limbic circui…
View article: Post-Concussive Orthostatic Tachycardia is Distinct from Postural Orthostatic Tachycardia Syndrome (POTS) in Children and Adolescents
Post-Concussive Orthostatic Tachycardia is Distinct from Postural Orthostatic Tachycardia Syndrome (POTS) in Children and Adolescents Open
Background: Orthostatic tachycardia (OT) affects some patients after concussion/mild traumatic brain injury (mTBI). In this study, we sought to identify the factors associated with increased risk for OT in patients with mTBI. Methods: We c…
View article: Cardiorespiratory Functioning in Youth with Persistent Post-Concussion Symptoms: A Pilot Study
Cardiorespiratory Functioning in Youth with Persistent Post-Concussion Symptoms: A Pilot Study Open
Dysregulation of the autonomic nervous system (ANS) may play an important role in the development and maintenance of persistent post-concussive symptoms (PPCS). Post-injury breathing dysfunction, which is influenced by the ANS, has not bee…
View article: Characteristics of Pediatric Mild Traumatic Brain Injury and Recovery in a Concussion Clinic Population
Characteristics of Pediatric Mild Traumatic Brain Injury and Recovery in a Concussion Clinic Population Open
These findings suggest that identification of subgroups of pediatric patients with mild TBI or concussion at risk for prolonged recovery could aid in better prognostic estimates and more targeted treatment interventions.
View article: Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of drug response and malignancy
Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of drug response and malignancy Open
Background Glioblastoma is a deadly brain tumor with median patient survival of 14.6 months. At the core of this malignancy are rare, highly heterogenous malignant stem-like tumor initiating cells. Aberrant signaling across the EGFR-PTEN-A…
View article: Multidisciplinary Therapy for Persistent Post-Concussion Symptoms: A Case Series from the UCLA Steve Tisch BrainSPORT Clinic
Multidisciplinary Therapy for Persistent Post-Concussion Symptoms: A Case Series from the UCLA Steve Tisch BrainSPORT Clinic Open
Objective To examine the effectiveness of a six-session multidisciplinary intervention of coordinated cognitive behavioral therapy (CBT) and programmed aerobic exercise for patients suffering from persistent post-concussion symptoms (PPCS)…
View article: Cardiorespiratory Stress-Response in Youth with Persistent Post-Concussion Symptoms
Cardiorespiratory Stress-Response in Youth with Persistent Post-Concussion Symptoms Open
Objective To evaluate cardiorespiratory response to a cognitive/emotional stressor in youth with persistent post-concussion symptoms (PPCS). Background The mechanisms of PPCS (symptoms lasting > 2 months) are poorly understood, but recent …
View article: Baseline Cardiorespiratory Function in Youth with Persistent Post-Concussion Symptoms
Baseline Cardiorespiratory Function in Youth with Persistent Post-Concussion Symptoms Open
Objective To evaluate cardiorespiratory functions in youth with persistent post-concussion symptoms compared to controls and to examine the predictive value of relevant demographic and medical variables. Background Recent studies propose t…
View article: Treating prolonged post-concussion symptoms in a pediatric patient with the simultaneous application of cognitive behavioral therapy and subthreshold exercise: A case study
Treating prolonged post-concussion symptoms in a pediatric patient with the simultaneous application of cognitive behavioral therapy and subthreshold exercise: A case study Open
Objective Use a novel, simultaneously applied cognitive behavioral therapy (CBT) and subthreshold exercise treatment (STE) for a 14-year old patient with persistent post-concussion symptoms (PPCS) to facilitate a return to function in scho…
View article: What Pediatricians Need to Know About the CDC Guideline on the Diagnosis and Management of mTBI
What Pediatricians Need to Know About the CDC Guideline on the Diagnosis and Management of mTBI Open
Pediatric traumatic brain injury (TBI) is a growing health concern, with over half a million TBI-related emergency department (ED) visits annually. However, this is likely an underestimate of the true incidence, with many children presenti…
View article: Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children
Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children Open
This guideline identifies the best practices for mTBI based on the current evidence; updates should be made as the body of evidence grows. In addition to the development of the guideline, CDC has created user-friendly guideline implementat…
View article: Diagnosis and Management of Mild Traumatic Brain Injury in Children
Diagnosis and Management of Mild Traumatic Brain Injury in Children Open
This systematic review was used to develop an evidence-based clinical guideline for the diagnosis and management of pediatric mTBI. While an increasing amount of research provides clinically useful information, this systematic review ident…