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View article: Carglumic acid and mesalazine as potential anti-mycobacterial agents: a spectroscopic study for repurposing drugs against <i>Mycobacterium tuberculosis</i> targeting its essential enzyme ThyX
Carglumic acid and mesalazine as potential anti-mycobacterial agents: a spectroscopic study for repurposing drugs against <i>Mycobacterium tuberculosis</i> targeting its essential enzyme ThyX Open
Mycobacterium tuberculosis (M.tb ) needs a key enzyme called ThyX to make thymidylate, which is essential for DNA replication and cell survival. In our previous study, carglumic acid (CGA) and mesalazine (MSZ) emerged as promising candidat…
View article: Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice.
Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice. Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb.) , inflicts one third of the humanity. Despite the availability of effective drug regimens, complete eradication of M.tb. remains challenging due to prolong treatment duration.…
View article: Essential mycobacterial gene glmM as an immunotherapeutic target against tuberculosis
Essential mycobacterial gene glmM as an immunotherapeutic target against tuberculosis Open
The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The cell wall of mycobacteria helps in its survival, pathogenicity, and virulence and provides resistance against different an…
View article: Structure-based drug repurposing to inhibit the replication-associated essential protein DnaG of Mycobacterium tuberculosis.
Structure-based drug repurposing to inhibit the replication-associated essential protein DnaG of Mycobacterium tuberculosis. Open
Background: Mycobacterium tuberculosis (M.tb), the etiological agent of Tuberculosis (TB), is the second leading cause of mortality after COVID-19, with a global death toll of 1.5 million in 2020. The escalating cases of drug-resistant TB …
View article: Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosis
Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosis Open
Epigenetics involves changing the gene function without any change in the sequence of the genes. In the case of tuberculosis (TB) infections, the bacilli, Mycobacterium tuberculosis ( M.tb ), uses epigenetics as a tool to protect itself fr…
View article: Unique C-terminal extension and interactome of <i>Mycobacterium tuberculosis</i> GlmU impacts its <i>in vivo</i> function and the survival of the pathogen
Unique C-terminal extension and interactome of <i>Mycobacterium tuberculosis</i> GlmU impacts its <i>in vivo</i> function and the survival of the pathogen Open
N-acetyl glucosamine-1-phosphate uridyltransferase (GlmU) is a bifunctional enzyme involved in the biosynthesis of Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). UDP-GlcNAc is a critical precursor for the synthesis of peptidoglycan …
View article: Identification and characterization of ARS‐like sequences as putative origin(s) of replication in human malaria parasite <i>Plasmodium falciparum</i>
Identification and characterization of ARS‐like sequences as putative origin(s) of replication in human malaria parasite <i>Plasmodium falciparum</i> Open
DNA replication is a fundamental process in genome maintenance, and initiates from several genomic sites (origins) in eukaryotes. In Saccharomyces cerevisiae , conserved sequences known as autonomously replicating sequences (ARSs) provide …
View article: Regulation of <scp><i>P</i></scp><i>lasmodium falciparum</i> <scp>O</scp>rigin <scp>R</scp>ecognition <scp>C</scp>omplex subunit 1 (<scp>PfORC</scp>1) function through phosphorylation mediated by <scp>CDK</scp>‐like kinase <scp>PK</scp>5
Regulation of <span><i>P</i></span><i>lasmodium falciparum</i> <span>O</span>rigin <span>R</span>ecognition <span>C</span>omplex subunit 1 (<span>PfORC</span>1) function through phosphorylation mediated by <span>CDK</span>‐like kinase <span>PK</span>5 Open
Summary P lasmodium falciparum O rigin R ecognition C omplex subunit 1 ( PfORC 1) has been implicated in DNA replication and var gene regulation. While the C ‐terminus is involved in DNA replication, the specific role of N ‐terminus has be…