Megan E. Arrington
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View article: Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects
Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects Open
Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67 phox , activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fM…
View article: Redox regulation of Rac1 by thiol oxidation
Redox regulation of Rac1 by thiol oxidation Open
The Rac1 GTPase is an essential and ubiquitous protein that signals through numerous pathways to control critical cellular processes, including cell growth, morphology, and motility. Rac1 deletion is embryonic lethal, and its dysregulation…
View article: The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2 Open
The RAS-related C3 botulinum toxin substrate 2 (RAC2) is a member of the RHO subclass of RAS superfamily GTPases required for proper immune function. An activating mutation in a key switch II region of RAC2 (RAC2E62K) involved i…
View article: Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects
Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects Open
Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67phox, activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fMLF…
View article: Reaction of Oxidized CuZnSOD with Polyphenols
Reaction of Oxidized CuZnSOD with Polyphenols Open
Several polyphenolic compounds, including twelve flavonols and a variety of lower molecular weight compounds were found to diminish the effects of CuZnSOD on NMR relaxation of fluoride ion in a pH and concentration dependent manner. While …