Megan K. Ruhland
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View article: Contextual control of CD8⁺ T cell priming by dendritic cell subsets in tumor and inflammatory microenvironments
Contextual control of CD8⁺ T cell priming by dendritic cell subsets in tumor and inflammatory microenvironments Open
Conventional dendritic cells orchestrate adaptive immunity by trafficking peripheral antigens to draining lymph nodes and presenting peptide–MHC complexes to prime naïve T cells. Migratory and lymph node resident conventional dendritic cel…
View article: Submicron-Sampling of Living Cells by Macrophages
Submicron-Sampling of Living Cells by Macrophages Open
SUMMARY PARAGRAPH An effective immune system must sample and appreciate healthy-self identity to prevent autoimmunity and to contrast to pathogenic insults 1–3 . Self-proteins are presented to T cells in the thymus during immune cell devel…
View article: Editorial: Antigen presentation in cancer immune responses
Editorial: Antigen presentation in cancer immune responses Open
View article: Sentinel Node B Cells Drive Epitope Spreading and Anti-Tumor T Cell Immunity by Recognition and Presentation of Extracellular Vesicle-Linked Antigens
Sentinel Node B Cells Drive Epitope Spreading and Anti-Tumor T Cell Immunity by Recognition and Presentation of Extracellular Vesicle-Linked Antigens Open
View article: Supplementary Figure from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Figure from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Figure from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Data from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Data from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determi…
View article: Data from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Data from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determi…
View article: Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Figure from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Figure from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Figure from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Open
Supplementary Table from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
View article: Supplementary Figure 1 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Supplementary Figure 1 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway Open
PDF file - 109K
View article: Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
Neoplastic cells rely on the tumor microenvironment (TME) for survival and progression factors. Indeed, senescent and cancer-associated fibroblasts (CAF) express factors that promote tumorigenesis that are collectively referred to as the s…
View article: Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 62K, legends for supplemental figures
View article: Supplementary Figure 2 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Supplementary Figure 2 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway Open
PDF file - 89K
View article: Supplementary Figure 2 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Supplementary Figure 2 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway Open
PDF file - 89K
View article: Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 401K, List of p38MAPK-dependent SASP factors and their overlap with publically available expression analyses from breast cancer-associated microenvironments
View article: Data from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Data from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway Open
Alterations in the microenvironment collaborate with cell autonomous mutations during the transformation process. Indeed, cancer-associated fibroblasts and senescent fibroblasts stimulate tumorigenesis in xenograft models. Because senescen…
View article: Data from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Data from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway Open
Alterations in the microenvironment collaborate with cell autonomous mutations during the transformation process. Indeed, cancer-associated fibroblasts and senescent fibroblasts stimulate tumorigenesis in xenograft models. Because senescen…
View article: Supplementary Figure 1 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Supplementary Figure 1 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway Open
PDF file - 109K
View article: Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 229K, qRT-PCR validation of RNA-seq analysis and TNFalpha ELISA on p38i treated mice
View article: Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 401K, List of p38MAPK-dependent SASP factors and their overlap with publically available expression analyses from breast cancer-associated microenvironments
View article: Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
Neoplastic cells rely on the tumor microenvironment (TME) for survival and progression factors. Indeed, senescent and cancer-associated fibroblasts (CAF) express factors that promote tumorigenesis that are collectively referred to as the s…
View article: Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 229K, qRT-PCR validation of RNA-seq analysis and TNFalpha ELISA on p38i treated mice
View article: Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 545K, SASP upregulation following bleomycin, NaB or replication-induced senescence. SASP mRNA stabilization in NaB-treated BJs and in bleomycin-treated IMR90s
View article: Supplementary Figure 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 194K, Senescence-associated beta-galactosidase staining of BJ fibroblasts and treatment of HaCaT-CBR cells with the p38MAPK small-molecule inhibitor SB203580
View article: Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 62K, legends for supplemental figures