Megan Krumpoch
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View article: Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling Open
Integrins play a critical role in signaling events that regulate cell adhesion, migration, and proliferation, processes that, when dysregulated, contribute to cancer progression. Recently, innovative approaches that target extracellular pr…
View article: Bacterial membrane vesicles restore gut anaerobiosis
Bacterial membrane vesicles restore gut anaerobiosis Open
Inflammation damages the epithelial cell barrier, allowing oxygen to leak into the lumen of the gut. Respiring E. coli and other Enterobacteriaceae produce proinflammatory lipopolysaccharide, exacerbating inflammatory bowel disease. Here w…
View article: 834 Integrin αvβ8 inhibitor improves immune checkpoint therapy in advanced ovarian cancer model and its activity can be monitored in blood
834 Integrin αvβ8 inhibitor improves immune checkpoint therapy in advanced ovarian cancer model and its activity can be monitored in blood Open
Background Ovarian cancer (OC) is the most lethal gynecologic malignancy. Despite the initial high response rate to chemotherapy, most patients relapse. Immunotherapy offers potential for long-term remission but single checkpoint inhibitio…
View article: 595 Inhibition of integrin αvβ8 in combination with low dose radiation induces antitumor effect in advanced immune checkpoint blockade refractory tumor model
595 Inhibition of integrin αvβ8 in combination with low dose radiation induces antitumor effect in advanced immune checkpoint blockade refractory tumor model Open
Background Integrin αvβ8 activates TGFβ in immune cells. αvβ8 inhibitors have been shown to potentiate immune checkpoint blockade (ICB) in preclinical models [1]. Radioimmunotherapy (RIT) induces immunogenic cell death and antigen presenta…
View article: A selective antibiotic for Lyme disease
A selective antibiotic for Lyme disease Open
View article: DOP64 Discovery of highly selective small-molecule oral inhibitors of integrin α4β7 for the treatment of inflammatory bowel diseases
DOP64 Discovery of highly selective small-molecule oral inhibitors of integrin α4β7 for the treatment of inflammatory bowel diseases Open
Background Integrins play a key role in facilitating immune cell trafficking throughout the body and represent an important receptor family for therapeutic intervention. In particular, the α4β7 integrin is a clinically validated target for…
View article: FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy
FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy Open
Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin ac…
View article: FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy
FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy Open
View article: Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis Open
Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated…
View article: Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function
Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function Open
To determine the roles of insulin and insulin-like growth factor 1 (IGF-1) action in adipose tissue, we created mice lacking the insulin receptor (IR), IGF-1 receptor (IGF1R), or both using Cre-recombinase driven by the adiponectin promote…