Megan L. Troxell
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View article: Genetic and immunohistochemical studies identify recurrent <i>ACTB</i> mutations and <scp>PTEN</scp> alterations in tubular adenomas of the breast
Genetic and immunohistochemical studies identify recurrent <i>ACTB</i> mutations and <span>PTEN</span> alterations in tubular adenomas of the breast Open
Aims Tubular adenoma of the breast (TAB) is a rare and understudied neoplasm, initially thought to represent a fibroadenoma (FA) variant. Recently, it has been shown that TABs lack MED12 mutations indicating a distinct pathogenesis, and an…
View article: Paradoxical cadherin-catenin immunostaining in a case of invasive mammary carcinoma with ductal and lobular differentiation: A molecular correlation
Paradoxical cadherin-catenin immunostaining in a case of invasive mammary carcinoma with ductal and lobular differentiation: A molecular correlation Open
We present a 66-year-old woman with right breast invasive mammary carcinoma with distinct areas consisting of lobular and tubular morphology. The areas with lobular morphology paradoxically demonstrated intact membranous expression of E-ca…
View article: Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer
Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer Open
New therapies are being developed for breast cancer, and in this process, some "old" biomarkers are reutilized and given a new purpose. It is not always recognized that by changing a biomarker's intended use, a new biomarker assay is creat…
View article: Principles of Analytic Validation of Immunohistochemical Assays: Guideline Update
Principles of Analytic Validation of Immunohistochemical Assays: Guideline Update Open
Context.— In 2014, the College of American Pathologists developed an evidence-based guideline to address analytic validation of immunohistochemical assays. Fourteen recommendations were offered. Per the National Academy of Medicine standar…
View article: Non-Full House Membranous Lupus Nephritis Represents a Clinically Distinct Subset
Non-Full House Membranous Lupus Nephritis Represents a Clinically Distinct Subset Open
Key Points Non-full house (NFH) membranous lupus nephritis (MLN) is a minor subset of all MLN cases. Patients with NFH MLN tend to be older when diagnosed with systemic lupus erythematosus, undergo first renal biopsy at an older age, and h…
View article: Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed i…
View article: Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
View article: Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed i…
View article: Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
View article: Polyacrylamide‐based hydrogel coatings improve biocompatibility of implanted pump devices
Polyacrylamide‐based hydrogel coatings improve biocompatibility of implanted pump devices Open
The introduction of transcutaneous and subcutaneous implants and devices into the human body instigates fouling and foreign body responses (FBRs) that limit their functional lifetimes. Polymer coatings are a promising solution to improve t…
View article: Polyacrylamide-based Hydrogel Coatings Improve Biocompatibility of Implanted Pump Devices
Polyacrylamide-based Hydrogel Coatings Improve Biocompatibility of Implanted Pump Devices Open
The introduction of transcutaneous and subcutaneous implants and devices into the human body instigates fouling and foreign body responses that limit their functional lifetimes. Polymer coatings are a promising solution to improve the bioc…
View article: Systemic Lupus Erythematosus and ANCA-Associated Vasculitis Overlap Syndrome: A Case Report
Systemic Lupus Erythematosus and ANCA-Associated Vasculitis Overlap Syndrome: A Case Report Open
Concomitant lupus nephritis and antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis is rare, and there is little guidance on the management and outcomes of these patients. A Hispanic woman in her early 40s with no co…
View article: Digital Image Analysis and Quantitative Bead Standards in Root Cause Analysis of Immunohistochemical Staining Variability: A Real-world Example
Digital Image Analysis and Quantitative Bead Standards in Root Cause Analysis of Immunohistochemical Staining Variability: A Real-world Example Open
Assessment of automated immunohistochemical staining platform performance is largely limited to the visual evaluation of individual slides by trained personnel. Quantitative assessment of stain intensity is not typically performed. Here we…
View article: NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission
NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission Open
Introduction: Kidney biopsy findings in patients with human immunodeficiency virus (HIV) are diverse, and optimal therapy for the various immune complex diseases in the setting of HIV is unknown. Case Presentation: A man with well-controll…
View article: Using American Type Culture Collection Cell Lines to Evaluate Interlaboratory Variables for Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Immunostaining
Using American Type Culture Collection Cell Lines to Evaluate Interlaboratory Variables for Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Immunostaining Open
Context.— Most laboratories currently use patient tissues for validating immunohistochemical stains. Objective.— To explore advantages of using cell lines with known antigenicity as a validation method. Design.— Five American Type Culture …
View article: Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination Open
To investigate whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines.
View article: One Hundred Years of the Pathology Medical Student Fellowship
One Hundred Years of the Pathology Medical Student Fellowship Open
Context.— The Pathology Medical Student Fellowship (PSF) is a unique, year-long immersive educational experience. Review of institutional archives describes a medical student “Fellowship in Pathology” founded in 1919. Objective.— To charac…
View article: Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer
Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer Open
ClinicalTrials.gov Identifier: NCT01042379.