Megan Lam
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View article: Systemic Immunomodulatory Treatments for Atopic Dermatitis
Systemic Immunomodulatory Treatments for Atopic Dermatitis Open
Importance There are multiple approved systemic treatments for atopic dermatitis. Lebrikizumab is a newly licensed biologic medication that has been compared to placebo in clinical trials but not to other systemic treatments. Objective To …
View article: Comparing binary efficacy outcomes for systemic immunomodulatory treatments for atopic dermatitis in a living systematic review and network meta-analysis
Comparing binary efficacy outcomes for systemic immunomodulatory treatments for atopic dermatitis in a living systematic review and network meta-analysis Open
Background Systemic treatments for atopic dermatitis (AD) are evaluated primarily in placebo-controlled trials with binary efficacy outcomes. In a living systematic review and network meta-analysis (NMA), we previously analysed continuous …
View article: Reporting of Harmonising Outcome Measures for Eczema (HOME) core outcome set instruments in randomized clinical trials for systemic treatments in atopic dermatitis
Reporting of Harmonising Outcome Measures for Eczema (HOME) core outcome set instruments in randomized clinical trials for systemic treatments in atopic dermatitis Open
The HOME initiative has successfully completed a core outcome set for atopic dermatitis (AD) trials, and most trials now include the core set instruments. However, to enable evidence synthesis of all relevant trials, reporting must also be…
View article: Fox-Fordyce disease treated with fractional CO2 laser: A case report
Fox-Fordyce disease treated with fractional CO2 laser: A case report Open
Fox-Fordyce disease (FFD) is a rare inflammatory condition affecting apocrine sweat glands.1Salloum A. Bouferraa Y. Bazzi N. et al.Pathophysiology, clinical findings, and management of Fox-Fordyce disease: a systematic review.J Cosmet Derm…
View article: A digital approach to workplace mental health: A randomized controlled trial examining the effectiveness of a smartphone-based personalized intervention
A digital approach to workplace mental health: A randomized controlled trial examining the effectiveness of a smartphone-based personalized intervention Open
Objective: This two-arm randomized controlled trial aimed to examine the effectiveness of a smartphone-based online platform which incorporates ecological momentary assessments and ecological momentary interventions with the use of machine…
View article: Systemic Therapy for Atopic Dermatitis in Older Adults and Adults With Comorbidities: A Scoping Review and International Eczema Council Survey
Systemic Therapy for Atopic Dermatitis in Older Adults and Adults With Comorbidities: A Scoping Review and International Eczema Council Survey Open
Data on systemic therapy for AD for older adults and adults with comorbidities are limited. Although IEC members' access to systemic therapies differs geographically, expert opinion suggests that dupilumab is preferred for those patients.
View article: Common Dermatologic Disorders in Down Syndrome: Systematic Review
Common Dermatologic Disorders in Down Syndrome: Systematic Review Open
Background Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS. …
View article: Characterization of discontinuation and nonpublication of phase <scp>III</scp> randomized clinical trials of psoriasis
Characterization of discontinuation and nonpublication of phase <span>III</span> randomized clinical trials of psoriasis Open
Journal Article Characterization of discontinuation and nonpublication of phase III randomized clinical trials of psoriasis Get access Megan Lam, Megan Lam Michael G. DeGroote School of Medicine, Faculty of Medicine McMaster University Ham…
View article: Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature
Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature Open
Darier’s disease (also known as keratosis follicularis or dyskeratosis follicularis) is an autosomal dominant inherited disorder which manifests as hyperkeratotic greasy papules in the first or second decade of life. Aside from symptom man…
View article: Racial Differences in the Prognosis and Survival of Cutaneous Melanoma From 1990 to 2020 in North America: A Systematic Review and Meta-Analysis
Racial Differences in the Prognosis and Survival of Cutaneous Melanoma From 1990 to 2020 in North America: A Systematic Review and Meta-Analysis Open
Background Factors influencing the difference in the diagnosis and treatment of melanoma in racial minority groups are well-described in the literature and include atypical presentations and socioeconomic factors that impede access to care…
View article: Common Dermatologic Disorders in Down Syndrome: Systematic Review (Preprint)
Common Dermatologic Disorders in Down Syndrome: Systematic Review (Preprint) Open
BACKGROUND Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS.…
View article: The Infodemic of COVID-19
The Infodemic of COVID-19 Open
While the fight against the COVID-19 pandemic remains centered around the great strides made in fields of biotechnology and epidemiology, an epidemic of misinformation and growing skepticism of the scientific community rages beneath the su…
View article: The Impact of Acne Treatment on Skin Bacterial Microbiota: A Systematic Review
The Impact of Acne Treatment on Skin Bacterial Microbiota: A Systematic Review Open
Background Microbial strains such as Cutibacterium acnes have been examined as contributors to the pathogenesis of acne. Given the prevalence of the disease among adolescents and adults, the overutilization of antimicrobial agents may bree…
View article: Accuracy of Automated Smartphone Applications for Detection of Melanomas in Adult Pigmented Lesions: A Systematic Review (Preprint)
Accuracy of Automated Smartphone Applications for Detection of Melanomas in Adult Pigmented Lesions: A Systematic Review (Preprint) Open
BACKGROUND Automated smartphone applications are increasingly being developed to provide an immediate risk assessment of lesions. However, the accuracy of these smartphone applications are not well known. OBJECTIVE To systematically rev…
View article: Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma
Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma Open
The findings of this systematic review and meta-analysis suggest an association between TCI use and risk of lymphoma but not other cancers. Combined with the low absolute risk of lymphoma, the potential increased risk attributable to TCI u…
View article: Safety of Systemic Medications Among Older Adults With Psoriasis and Atopic Dermatitis: A Systematic Review of Observational Studies
Safety of Systemic Medications Among Older Adults With Psoriasis and Atopic Dermatitis: A Systematic Review of Observational Studies Open
Background Psoriasis and atopic dermatitis are common among older adults (≥65 years old), but clinical trials often exclude that population. Objective To synthesize evidence from observational studies on the safety of systemic therapies (c…