Mitchell D. Miller
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View article: Completion of partial structures using Patterson maps with the <i>CrysFormer</i> machine-learning model
Completion of partial structures using Patterson maps with the <i>CrysFormer</i> machine-learning model Open
Protein structure determination has long been one of the primary challenges of structural biology, to which deep machine learning (ML)-based approaches have increasingly been applied. However, these ML models generally do not directly inco…
View article: Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes
Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes Open
The photoreaction and commensurate structural changes of a chromophore within biological photoreceptors elicit conformational transitions of the protein promoting the switch between deactivated and activated states. We investigated how thi…
View article: 0761 Detailed Three-Year Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe Obstructive Sleep Apnea
0761 Detailed Three-Year Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe Obstructive Sleep Apnea Open
Introduction Proximal hypoglossal nerve stimulation (pHGNS) has been shown in the THN3 randomized, controlled trial to produce durable three-year improvements in quality of life, oxygenation, and sleep-disordered breathing (Apnea-Hypopnea …
View article: 0718 Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe OSA: OSPREY Randomized Controlled Trial
0718 Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe OSA: OSPREY Randomized Controlled Trial Open
Introduction Clinically significant improvement of the total Apnea-hypopnea index (AHI) in the OSPREY randomized, controlled trial (RCT) of proximal hypoglossal nerve stimulation (pHGNS) was demonstrated for patients receiving active treat…
View article: RecCrysFormer: Refined Protein Structural Prediction from 3D Patterson Maps via Recycling Training Runs
RecCrysFormer: Refined Protein Structural Prediction from 3D Patterson Maps via Recycling Training Runs Open
Determining protein structures at an atomic level remains a significant challenge in structural biology. We introduce $\texttt{RecCrysFormer}$, a hybrid model that exploits the strengths of transformers with the aim of integrating experime…
View article: Patients with Persistent Mild Psoriasis after Treatment with Ustekinumab Achieved Greater Improvements in Skin Clearance and Patient-reported Outcomes after Switching to Guselkumab in the Phase 3 NAVIGATE Trial
Patients with Persistent Mild Psoriasis after Treatment with Ustekinumab Achieved Greater Improvements in Skin Clearance and Patient-reported Outcomes after Switching to Guselkumab in the Phase 3 NAVIGATE Trial Open
Mild psoriasis may be burdensome; if symptoms are inadequately controlled, switching therapy may be warranted. In the Phase 3 NAVIGATE trial, patients with moderate-to-severe plaque psoriasis received ustekinumab for 16 weeks. Patients wit…
View article: <tt>CrysFormer</tt>: Protein structure determination via Patterson maps, deep learning, and partial structure attention
CrysFormer: Protein structure determination via Patterson maps, deep learning, and partial structure attention Open
Determining the atomic-level structure of a protein has been a decades-long challenge. However, recent advances in transformers and related neural network architectures have enabled researchers to significantly improve solutions to this pr…
View article: Heterotrimeric Collagen Helix with High Specificity of Assembly Results in a Rapid Rate of Folding
Heterotrimeric Collagen Helix with High Specificity of Assembly Results in a Rapid Rate of Folding Open
The most abundant natural collagens form heterotrimeric triple helices. Synthetic mimics of collagen heterotrimers have been found to fold slowly, even compared to the already slow rates of homotrimeric helices. These prolonged folding rat…
View article: Deep learning to detect left ventricular structural abnormalities in chest X-rays
Deep learning to detect left ventricular structural abnormalities in chest X-rays Open
Background and Aims Early identification of cardiac structural abnormalities indicative of heart failure is crucial to improving patient outcomes. Chest X-rays (CXRs) are routinely conducted on a broad population of patients, presenting an…
View article: P805: Rare clinical gene variant of GBE1: Glycogen storage disease IV
P805: Rare clinical gene variant of GBE1: Glycogen storage disease IV Open
Glycogen storage diseases (GSDs) are inherited inborn errors of carbohydrate metabolism. Specifically, GSD-IV is an autosomal recessive disorder due to GBE1 gene mutations with estimated prevalence of 1:6000,000-1:800,0000. It is character…
View article: CrysFormer: Protein Structure Prediction via 3d Patterson Maps and Partial Structure Attention
CrysFormer: Protein Structure Prediction via 3d Patterson Maps and Partial Structure Attention Open
Determining the structure of a protein has been a decades-long open question. A protein's three-dimensional structure often poses nontrivial computation costs, when classical simulation algorithms are utilized. Advances in the transformer …
View article: Deep learning-based predictions of electron-density maps from input Patterson maps
Deep learning-based predictions of electron-density maps from input Patterson maps Open
We have been testing the ability of deep learning to predict electron density maps given an input Patterson map.Hurwitz [1] reported success in determining the positions of 10 randomly positioned, identical atoms from their Patterson maps …
View article: Protein target highlights in <scp>CASP15</scp> : Analysis of models by structure providers
Protein target highlights in <span>CASP15</span> : Analysis of models by structure providers Open
We present an in‐depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were c…
View article: A deep learning solution for crystallographic structure determination
A deep learning solution for crystallographic structure determination Open
The general de novo solution of the crystallographic phase problem is difficult and only possible under certain conditions. This paper develops an initial pathway to a deep learning neural network approach for the phase problem in protein …
View article: 0453 3-Year Outcomes of Proximal Hypoglossal Nerve Stimulation in the THN3 Controlled Trial
0453 3-Year Outcomes of Proximal Hypoglossal Nerve Stimulation in the THN3 Controlled Trial Open
Introduction The THN3 randomized, controlled trial of moderate to severe obstructive sleep apnea (OSA) showed that proximal (“targeted”) hypoglossal nerve stimulation (HGNS) safely improved sleep-disordered breathing (SDB) and quality of l…
View article: Parental Acceptance of Silver Diamine Fluoride Treatment for Carious Lesions
Parental Acceptance of Silver Diamine Fluoride Treatment for Carious Lesions Open
Objectives The purpose of this study was to determine parental acceptability of the use of Silver Diamine Fluoride (SDF) as an alternative treatment for carious legions. In addition, we examined potential factors influencing higher levels …
View article: Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid
Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid Open
Genetic code expansion technology allows for the use of noncanonical amino acids (ncAAs) to create semisynthetic organisms for both biochemical and biomedical applications. However, exogenous feeding of chemically synthesized ncAAs at high…
View article: Real-Time Scene Monitoring for Deaf-Blind People
Real-Time Scene Monitoring for Deaf-Blind People Open
It is estimated that at least 15 million people worldwide live with severe deaf-blindness, with many more experiencing varying degrees of deaf-blindness. The existing options of assistance are mostly limited to walking canes, guide dogs an…
View article: Structures of MfnG, an <i>O</i>-methyltransferase involved in the biosynthesis of marformycins from multiple crystal forms
Structures of MfnG, an <i>O</i>-methyltransferase involved in the biosynthesis of marformycins from multiple crystal forms Open
Marformycins are anti-infective natural products isolated from a deep sea sediment-derived Streptomyces drozdowiczii strain.These cyclodepsipetides contain O-methyl-D-Tyr.Liu et al., (Org.Lett.2015, 17, 1509-1512) identified a SAM-dependen…
View article: 0765 Enhanced Response to Targeted Hypoglossal Nerve Stimulation in Patients with Normal Sleep Efficiency: A THN3 Post-Hoc Analysis
0765 Enhanced Response to Targeted Hypoglossal Nerve Stimulation in Patients with Normal Sleep Efficiency: A THN3 Post-Hoc Analysis Open
Introduction THN3 was the first reported parallel-arm, randomized controlled trial of hypoglossal nerve stimulation (HGNS), wherein targeted HGNS (THN) was shown to be safe and efficacious at ameliorating sleep disordered breathing in sele…
View article: 0766 Group Trajectories Demonstrate Robust Effects of Targeted Hypoglossal Nerve Stimulation in the THN3 Randomized, Controlled Trial
0766 Group Trajectories Demonstrate Robust Effects of Targeted Hypoglossal Nerve Stimulation in the THN3 Randomized, Controlled Trial Open
Introduction THN3 was the first reported parallel-arm, randomized controlled trial (RCT) of hypoglossal nerve stimulation (HGNS), wherein targeted HGNS (THN) was shown to be safe and efficacious at ameliorating sleep disordered breathing i…