Megan Null
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View article: Immune subphenotypes of tuberculosis and mortality in adults with sepsis and a high prevalence of HIV in East Africa
Immune subphenotypes of tuberculosis and mortality in adults with sepsis and a high prevalence of HIV in East Africa Open
Introduction Sepsis causes high mortality among people living with HIV in Africa, yet immune response data are limited. We identified immune subphenotypes of adults with sepsis and a high prevalence of HIV in East Africa. Methods We determ…
View article: A narrative review of the pathophysiology of sepsis in sub-Saharan Africa: Exploring the potential for corticosteroid therapy
A narrative review of the pathophysiology of sepsis in sub-Saharan Africa: Exploring the potential for corticosteroid therapy Open
Sepsis remains a significant global health threat with a disproportionate burden in low-income countries including those in sub-Saharan Africa where case fatality rates are as high as 30% to 50%. Defined as a severe systemic response to in…
View article: Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens
Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens Open
Neonatal sepsis is a leading cause of childhood mortality. Understanding immune cell development can inform strategies to combat this. MR1-restricted T (MR1T) cells can be defined by their recognition of small molecules derived from microb…
View article: Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens
Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens Open
Neonatal sepsis is a leading cause of childhood mortality. Understanding immune cell development can inform strategies to combat this. MR1-restricted T (MR1T) cells can be defined by their recognition of small molecules derived from microb…
View article: The Universal Vital Assessment (UVA) score at 6 hours post-resuscitation predicts mortality in hospitalized adults with severe sepsis in Mbarara, Uganda
The Universal Vital Assessment (UVA) score at 6 hours post-resuscitation predicts mortality in hospitalized adults with severe sepsis in Mbarara, Uganda Open
Sepsis is the leading cause of global death with the highest burden found in sub-Saharan Africa (sSA). The Universal Vital Assessment (UVA) score is a validated resource-appropriate clinical tool to identify hospitalized patients in sSA wh…
View article: Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis
Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure, and this vulnerability is secondary to insufficient …
View article: Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells
Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells Open
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable int…
View article: Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation
Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation Open
MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathwa…
View article: Early empiric anti- <i>Mycobacterium tuberculosis</i> therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial
Early empiric anti- <i>Mycobacterium tuberculosis</i> therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial Open
Introduction Sub-Saharan Africa shoulders the highest burden of global sepsis and associated mortality. In high HIV and tuberculosis (TB) prevalent settings such as sub-Saharan Africa, TB is the leading cause of sepsis. However, anti-TB th…
View article: Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells
Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells Open
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable int…
View article: Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells
Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells Open
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable int…
View article: Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans
Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans Open
MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-asso…
View article: Atypical TRAV1-2− T cell receptor recognition of the antigen-presenting molecule MR1
Atypical TRAV1-2− T cell receptor recognition of the antigen-presenting molecule MR1 Open
MR1 presents vitamin B-related metabolites to mucosal associated invariant T (MAIT) cells, which are characterized, in part, by the TRAV1-2+ αβ T cell receptor (TCR). In addition, a more diverse TRAV1-2- MR1-restricted T cell repertoire ex…
View article: Postnatal Expansion, Maturation and Functionality of MR1T Cells in Humans
Postnatal Expansion, Maturation and Functionality of MR1T Cells in Humans Open
MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-asso…
View article: Recognition of CD8<sup>+</sup>T-cell epitopes to identify adults with pulmonary tuberculosis
Recognition of CD8<sup>+</sup>T-cell epitopes to identify adults with pulmonary tuberculosis Open
Current immune assays have limited capacity to identify individuals with TB. Two novel immune-based assays show promise as a new approach to diagnose TB once incorporated into existing technologies.http://ow.ly/4cg330okh4g
View article: MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage
MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage Open
A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells.
View article: T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells
T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells Open
HLA-E is a non-conventional MHC Class I molecule that has been recently demonstrated to present pathogen-derived ligands, resulting in the TCR-dependent activation of αβ CD8+ T cells. The goal of this study was to characterize the ligandom…