Explanipedia

Preservation and Clonal Behavior of Extrachromosomal DNA in Patient-Derived Xenograft Models of Childhood Cancers Open

Rishaan Kenkre, Jon D. Larson, Owen Chapman, Jens Luebeck, Yan Yuen Lo , et al. · 2025

Extrachromosomal DNA (ecDNA) is a powerful oncogenic driver linked to poor prognosis in pediatric cancers. Whole-genome sequencing of 338 patient-derived xenograft (PDX) samples and 127 matched primary tumors across multiple childhood canc…

Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors Open

Owen Chapman, Sunita Sridhar, Eugene Yui‐Ching Chow, Rishaan Kenkre, John L. Kirkland , et al. · 2025

Circular extrachromosomal DNA (ecDNA) is a common form of oncogene amplification in aggressive cancers. The frequency and diversity of ecDNA has been catalogued in adult and some childhood cancers; however, its role in most pediatric cance…

ecPath detects ecDNA in tumors from histopathology images Open

Mudra Choudhury, Lihe Liu, Anamika Yadav, Owen Chapman, Zahra Ahmadi , et al. · 2024

Circular extrachromosomal DNA (ecDNA) can drive tumor initiation, progression and resistance in some of the most aggressive cancers and is emerging as a promising anti-cancer target. However, detection currently requires costly whole-genom…

Shareable artificial intelligence to extract cancer outcomes from electronic health records for precision oncology research Open

Kenneth L. Kehl, Justin Jee, Karl Pichotta, Megan Paul, Pavel Trukhanov , et al. · 2024

QOL-25. DETERMINING THE BURDEN OF SLEEP PATHOLOGY AMONG PEDIATRIC NEURO-ONCOLOGY PATIENTS Open

Lanipua Yeh‐Nayre, Jennifer Elster, Sunita Sridhar, Megan Paul · 2024

BACKGROUND Children with brain and spinal cord tumors are at higher risk for sleep disruption. The incidence and characteristics of sleep difficulties in this population is not well understood. Our aim is to use survey and chart review to …

TRLS-13. MULTI-OMICS AND FUNCTIONAL PRECISION MEDICINE FOR NEWLY DIAGNOSED AND RECURRENT PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS Open

John R. Crawford, Yan Yuen Lo, Meghana S. Pagadala, Owen Chapman, Sunita Sridhar , et al. · 2024

BACKGROUND Comprehensive molecular characterization of pediatric brain tumors has led to a more refined diagnosis. However, the feasibility of performing multi-omic and functional precision medicine approaches using ex-vivo drug screening …

TRLS-04. EARLY INSIGHTS FROM PNOC027: PERSONALIZED TREATMENT APPROACHES BASED ON REAL-TIME DRUG SCREENING AND GENOMIC TESTING IN PEDIATRIC AND ADOLESCENT PATIENTS WITH RECURRENT MEDULLOBLASTOMA Open

Margaret Shatara, Megan Paul, Janel Long-Boyle, Ashley Meyer, Shannon Raber , et al. · 2024

BACKGROUND PNOC027, a clinical trial conducted by the Pediatric Neuro-Oncology Consortium (PNOC), explores a precision medicine strategy with up to four FDA-approved agents integrating real-time drug screening with whole exome DNA and RNA …

CTNI-69. REAL-TIME DRUG SCREENING AND GENOMIC TESTING TO DETERMINE INDIVIDUALIZED TREATMENT PLANS IN CHILDREN AND YOUNG ADULTS WITH RELAPSED MEDULLOBLASTOMA: PRELIMINARY REPORT OF PNOC027 Open

Margaret Shatara, Megan Paul, Janel Boyle-Lang, Ashley Meyer, Shannon Raber , et al. · 2023

While current upfront multi-modal treatment for medulloblastoma is effective in many cases, for patients who relapse or don’t respond to initial therapy, effective treatment options are limited and novel therapeutic approaches are needed. …

Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia? Open

Duncan B. Mackie, Dennis Z. Kuo, Megan Paul, Jennifer Elster · 2023

While temperature one-hour post-acetaminophen was higher among patients with bacteremia and was a significant predictor of bacteremia, fever response in isolation lacks sufficient predictive value to impact clinical decision-making. Future…

Central sleep apnoea as an initial presentation of a posterior fossa juvenile pilocytic astrocytoma Open

Clarice Ho, Megan Paul, Michael L. Levy, John R. Crawford · 2022

A previously healthy patient of middle childhood presented for intermittent dull headaches without nausea, vomiting, photophobia/phonophobia and a 4-month history of snoring. Neurological examination at presentation was unremarkable. Compr…

The role of methylation profiling in histologically diagnosed neurocytoma: a case series Open

Adam Z. Kalawi, Denise Malicki, Zied Abdullaev, Drew Pratt, Martha Quezado , et al. · 2022

Purpose To highlight the clinical, neuroradiographic, neuropathologic, and molecular features of histologically identified neurocytoma in a pediatric cohort and highlight the evolving use methylation profiling in providing diagnostic clari…

Does Fever Response to Acetaminophen Predict Blood Stream Infections in Febrile Neutropenia? Open

Duncan Mackie, Dennis John Kuo, Megan Paul, Jennifer Elster · 2022

Background: There is a need to identify clinical parameters for early and effective risk stratification and prediction of bacterial blood stream infections (BSI) in patients with febrile neutropenia (FN). Acetaminophen is used widely to tr…

Integration of Neuro-Oncology and Pediatric Palliative Care at Diagnosis in the Outpatient Setting. (FR436) Open

Kimberly A. Bower, Jo Anne Auger, Samantha Z. Brown, Lanipua Yeh‐Nayre, John R. Crawford , et al. · 2020

Characterization of G-CSF receptor expression in medulloblastoma Open

Megan Paul, Yuchen Huo, Andrea J. Liu, Jacqueline Lesperance, Alexandra Garancher , et al. · 2020

Background Identifying mechanisms of medulloblastoma recurrence is a key to improving patient survival, and targeting treatment-resistant subpopulations within tumors could reduce disease recurrence. Expression of the granulocyte colony-st…

Clinical Impact of Next-generation Sequencing in Pediatric Neuro-Oncology Patients: A Single-institutional Experience Open

Valentin Barsan, Megan Paul, Hamza Gorsi, Denise Malicki, Jennifer Elster , et al. · 2019

The implementation of next-generation sequencing (NGS) in pediatric neuro-oncology may impact diagnosis, prognosis, therapeutic strategies, clinical trial enrollment, and germline risk. We retrospectively analyzed 58 neuro-oncology patient…

The multikinase inhibitor RXDX-105 is effective against neuroblastoma<i>in vitro</i>and<i>in vivo</i> Open

Sean Flynn, Jacqueline Lesperance, Andrew Macias, Nikki Phanhthilath, Megan Paul , et al. · 2019

Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of…

MEDU-41. TARGETING GRANULOCYTE COLONY STIMULATION FACTOR RECEPTOR EXPRESSING MEDULLOBLASTOMA CELLS Open

Megan Paul, Jacqueline Lesperance, Peter E. Zage · 2019

Medulloblastoma can often be cured with resection, radiation, and chemotherapy, but recurrent disease has a dismal prognosis. Identifying mechanisms of disease recurrence is key to improving overall survival. Identifying sub-populations of…

Treatment of Recurrent Refractory Pediatric Pre-B Acute Lymphoblastic Leukemia Using Inotuzumab Ozogamicin Monotherapy Resulting in CD22 Antigen Expression Loss as a Mechanism of Therapy Resistance Open

Megan Paul, Victor Wong, Paula Aristizabal, Dennis John Kuo · 2019

Background: Inotuzumab ozogamicin is a novel antibody-drug conjugate that targets CD22, a common antigen on pre-B acute lymphoblastic leukemia cells. Observations: A 7-year-old boy with pre-B acute lymphoblastic leukemia in his second rela…

Hematologic Manifestations of Nutritional Deficiencies: Early Recognition is Essential to Prevent Serious Complications Open

Jennifer C. Yu, Ksenya Shliakhtsitsava, YunZu M. Wang, Megan Paul, Lauge Farnaes , et al. · 2018

Nutritional deficiencies, including deficiencies of vitamin B 12 , copper, and vitamin C, may result in cytopenias and hematologic symptoms. Early recognition of these deficiencies is imperative for prompt treatment and improvement in hema…

MBRS-06. THE ROLE OF G-CSF RECEPTOR SURFACE EXPRESSION IN MEDULLOBLASTOMA PATHOGENESIS Open

Megan Paul, Peter E. Zage · 2018

Medulloblastoma recurrence portends a dismal prognosis. Identifying sub-populations of medulloblastoma tumors with stem cell-like properties holds promise for reducing disease recurrence, but no unifying marker of medulloblastoma cancer st…

HGG-08. BONE METASTASES IN PEDIATRIC HIGH GRADE GLIOMA: A CASE SERIES AND REVIEW OF THE LITERATURE Open

Megan Paul, John R. Crawford, Jennifer Elster · 2018

High grade glioma (HGG) has poor outcomes in adults and children. Death usually occurs from progressive intracranial disease. Extraneural metastases are rare in HGG, and poorly characterized with only a few small case series in adults and …

Challenges of assessing response to therapy in non-Hodgkin’s lymphoma of the bone Open

Megan Paul, Dennis John Kuo · 2018

A 17-year-old male adolescent was diagnosed with diffuse large B cell lymphoma arising from the right humeral head. The lymphoma was found to be isolated to the bone, with a very small extraosseous component. After completion of a standard…

Deep Vein Thrombosis in a Young, Healthy Baseball Catcher: A Case Report and Review of the Literature Open

Kimberly K. Abood, Megan Paul, Dennis John Kuo · 2018

Venous thromboembolism is becoming increasingly recognized as a significant cause of morbidity and mortality in the hospitalized pediatric population. However, young healthy athletes can present with unique risk factors for deep vein throm…

Severe Neuropathic Pain With Concomitant Administration of Vincristine and Posaconazole Open

Mark John-Yung Lin, Megan Paul, Dennis John Kuo · 2018

Vincristine is a chemotherapeutic agent with a potential toxicity of sensorimotor peripheral neuropathy. Patients receiving chemotherapy are in an immunocompromised state and may require antifungal agents. Triazole antifungals are known in…

Treatment of immune thrombocytopenic purpura associated with cytomegalovirus infection in a child with pre-B cell acute lymphoblastic leukaemia after central nervous system relapse Open

Ashley R. Martinez, Megan Paul, Dennis John Kuo · 2017

A 13-year-old male patient with a history of pre-B cell acute lymphoblastic leukaemia (ALL) with isolated central nervous system relapse on maintenance chemotherapy presented with severe thrombocytopenia refractory to platelet transfusions…

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