Megan R. Beggs
YOU?
Author Swipe
View article: MaxiMoM InForM: individualised fortification of human milk for very low birthweight infants— protocol of a three-arm randomised clinical trial
MaxiMoM InForM: individualised fortification of human milk for very low birthweight infants— protocol of a three-arm randomised clinical trial Open
Introduction To meet the elevated nutritional requirements of very low birthweight (<1500 g, VLBW) infants during hospitalisation, many neonatal units routinely add a fixed dose of multinutrient fortifier to human milk. Individualised appr…
View article: Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies
Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies Open
Introduction Human milk (HM) contains a multitude of nutritive and nonnutritive bioactive compounds that support infant growth, immunity and development, yet its complex composition remains poorly understood. Integrating diverse scientific…
View article: Maternal multiple micronutrient supplementation in rural Pakistan increased some milk micronutrient concentrations, but not infant growth, at three-months postpartum: a randomized controlled trial substudy
Maternal multiple micronutrient supplementation in rural Pakistan increased some milk micronutrient concentrations, but not infant growth, at three-months postpartum: a randomized controlled trial substudy Open
View article: Does Pasteurized Donor Human Milk Provide Adequate Intakes of Minerals and Trace Elements for Term-Born Infants?
Does Pasteurized Donor Human Milk Provide Adequate Intakes of Minerals and Trace Elements for Term-Born Infants? Open
View article: Daily Multiple Micronutrient Supplements Increased Human Milk Iodine and Vitamin A Levels, but Not Vitamin B12 or Folate, Among Lactating Women in Rural Pakistan: RCT Substudy
Daily Multiple Micronutrient Supplements Increased Human Milk Iodine and Vitamin A Levels, but Not Vitamin B12 or Folate, Among Lactating Women in Rural Pakistan: RCT Substudy Open
View article: Is Maternal Body Weight or Composition Associated with Onset of Lactogenesis II, Human Milk Production, or Infant Consumption of Mother’s Own Milk? A Systematic Review and Meta-Analysis
Is Maternal Body Weight or Composition Associated with Onset of Lactogenesis II, Human Milk Production, or Infant Consumption of Mother’s Own Milk? A Systematic Review and Meta-Analysis Open
Maternal adiposity impacts lactation performance, but the pathways are unclear. We conducted a systematic review to understand whether maternal adiposity (body mass index [BMI] or percentage fat mass) is associated with onset of lactogenes…
View article: Increased Slc34a2 expression and paracellular phosphate permeability contribute to high intestinal phosphate absorption in young mice
Increased Slc34a2 expression and paracellular phosphate permeability contribute to high intestinal phosphate absorption in young mice Open
Aim Phosphorus is a critical constituent of bone as a component of hydroxyapatite. Bone mineral content accrues rapidly early in life necessitating a positive phosphorus balance, which could be established by a combination of increased ren…
View article: Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2 Dependent Increases in Small Intestinal Calcium Permeability
Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2 Dependent Increases in Small Intestinal Calcium Permeability Open
A higher concentration of calcium in breast milk than blood favors paracellular calcium absorption enabling growth during postnatal development. We aimed to determine whether suckling animals have greater intestinal calcium permeability to…
View article: Donor human milk processing and its impact on infant digestion: A systematic scoping review of in vitro and in vivo studies
Donor human milk processing and its impact on infant digestion: A systematic scoping review of in vitro and in vivo studies Open
When there is an inadequate supply of mother's milk, pasteurized donor human milk is preferred over formula to supplement feeds for preterm infants. Although providing donor milk helps to improve feeding tolerance and reduce necrotizing en…
View article: Regulation of 1 and 24 hydroxylation of vitamin D metabolites in the proximal tubule
Regulation of 1 and 24 hydroxylation of vitamin D metabolites in the proximal tubule Open
Calcium and phosphate are critical for numerous physiological processes. Consequently, the plasma concentration of these ions are tightly regulated. Calcitriol, the active form of vitamin D, is a positive modulator of mineralization as wel…
View article: Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis
Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis Open
Significance Significant calcium absorption across renal and intestinal epithelia occurs via the paracellular pathway. However, the identity of the paracellular pore involved is unknown. Claudin-2 and claudin-12 contribute paracellular cal…
View article: Colonic Handling of Calcium Appears To Occur Via Different Pathways in Mouse Models of Infants and Adults
Colonic Handling of Calcium Appears To Occur Via Different Pathways in Mouse Models of Infants and Adults Open
OBJECTIVES: Calcium (Ca(2+)) is a vital micronutrient for many physiological functions with the greatest rate of accumulation occurring during the critical period of infancy. Previous work has demonstrated that molecular mechanisms of inte…
View article: Canadian Nutrition Society: 2021 Scientific Abstracts: Canadian Nutrition Society Annual Conference
Canadian Nutrition Society: 2021 Scientific Abstracts: Canadian Nutrition Society Annual Conference Open
An unhealthy diet is a critical modifiable risk factor for chronic diseases.The Diabetes Canada Clinical Practice (DCCP) Guidelines encourage healthy eating by recommending consumption of certain foods or nutrients (e.g., fruits and vegeta…
View article: Delineation of molecular mechanisms of intestinal calcium absorption during postnatal development
Delineation of molecular mechanisms of intestinal calcium absorption during postnatal development Open
Infants and children must maintain a positive calcium balance for appropriate growth. Evidence suggests that adaptations in intestinal absorption of calcium are the major determinant of this net balance. However, the molecular details of t…
View article: Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability
Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability Open
The renal proximal tubule (PT) is responsible for the reabsorption of approximately 65% of filtered calcium, primarily via a paracellular pathway. However, which protein(s) contribute this paracellular calcium pore is not known. The claudi…
View article: Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease Open
The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence implicates a role for defective calcium reabsorption in the renal proximal tubule. We hypothesized that claudin-2, a paracellular cation channel p…
View article: The Jejunum and Ileum Mediate Increased Calcium Absorption for Bone Mineralization During Postnatal Development via TRPV6 and Cav1.3 (OR26-07-19)
The Jejunum and Ileum Mediate Increased Calcium Absorption for Bone Mineralization During Postnatal Development via TRPV6 and Cav1.3 (OR26-07-19) Open
View article: Activation of the calcium-sensing receptor attenuates TRPV6-dependent intestinal calcium absorption
Activation of the calcium-sensing receptor attenuates TRPV6-dependent intestinal calcium absorption Open
Plasma calcium (Ca2+) is maintained by amending the release of parathyroid hormone and through direct effects of the Ca2+ sensing receptor (CaSR) in the renal tubule. Combined, these mechanisms alter intestinal Ca2+ absorption by modulatin…
View article: Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation
Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation Open
View article: TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning
TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning Open
View article: Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect
Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect Open
Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAI…
View article: Effects of phospho- and calciotropic hormones on electrolyte transport in the proximal tubule
Effects of phospho- and calciotropic hormones on electrolyte transport in the proximal tubule Open
Calcium and phosphate are critical for a myriad of physiological and cellular processes within the organism. Consequently, plasma levels of calcium and phosphate are tightly regulated. This occurs through the combined effects of the phosph…
View article: Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation
Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation Open
Significant alterations in maternal calcium (Ca 2+ ) and magnesium (Mg 2+ ) balance occur during lactation. Ca 2+ is the primary divalent cation mobilized into breast milk by demineralization of the skeleton and alterations in intestinal a…
View article: Intestinal absorption and renal reabsorption of calcium throughout postnatal development
Intestinal absorption and renal reabsorption of calcium throughout postnatal development Open
Calcium is vital for many physiological functions including bone mineralization. Postnatal deposition of calcium into bone is greatest in infancy and continues through childhood and adolescence until peek mineral density is reached in earl…
View article: Feeding Practices and Outcomes of Infants Undergoing the Norwood Procedure
Feeding Practices and Outcomes of Infants Undergoing the Norwood Procedure Open
Objective. To determine if early pre- and postoperative enteral feeding was associated with improved postoperative outcomes in infants with hypoplastic left heart syndrome undergoing the Norwood procedure. Study Design. Retrospective chart…
View article: Ultrastructural and immunohistochemical localization of plasma membrane Ca<sup>2+</sup>-ATPase 4 in Ca<sup>2+</sup>-transporting epithelia
Ultrastructural and immunohistochemical localization of plasma membrane Ca<sup>2+</sup>-ATPase 4 in Ca<sup>2+</sup>-transporting epithelia Open
Plasma membrane Ca 2+ -ATPases (PMCAs) participate in epithelial Ca 2+ transport and intracellular Ca 2+ signaling. The Pmca4 isoform is enriched in distal nephron isolates and decreased in mice lacking the epithelial transient receptor po…
View article: Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction
Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction Open
Aquaporin-1 (AQP1) enables greatly enhanced water flux across plasma membranes. The cytosolic carboxy terminus of AQP1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences. CAII colocalizes with AQP1 in …