Megan Rossi
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View article: Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations
Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations Open
Increasing evidence suggests a microbial pathogenesis in irritable bowel syndrome (IBS) but the relationship remains elusive. Fecal DNA samples from 120 patients with IBS, 82 Mexican (IBS-C: n = 33, IBS-D: n = 24, IBS-M: n = 25) and 38 Bri…
View article: Faecal and urine metabolites, but not gut microbiota, may predict response to low FODMAP diet in irritable bowel syndrome
Faecal and urine metabolites, but not gut microbiota, may predict response to low FODMAP diet in irritable bowel syndrome Open
Summary Background The low FODMAP diet (LFD) leads to clinical response in 50%–80% of patients with irritable bowel syndrome (IBS). It is unclear why only some patients respond. Aims To determine if differences in baseline faecal microbiot…
View article: Psyllium reduces inulin-induced colonic gas production in IBS: MRI and <i>in vitro</i> fermentation studies
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and <i>in vitro</i> fermentation studies Open
Objective Health-promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with IBS, limiting their intake. Our aim was to test if coadministering psyllium with inulin would reduce gas production. Design…
View article: Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies
Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies Open
Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would …
View article: O62 Psyllium reduces colonic hydrogen production following ingestion of inulin in irritable bowel syndrome
O62 Psyllium reduces colonic hydrogen production following ingestion of inulin in irritable bowel syndrome Open
Introduction Patients with irritable bowel syndrome (IBS) often develop symptoms of gas and flatulence after intake of the prebiotic inulin, leading to dietary avoidance that may have deleterious effects on gut microbiota. Our aim was to d…
View article: Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn’s Disease
Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn’s Disease Open
There is an association between food additive emulsifiers and the prevalence of Crohn’s disease. This study aimed to investigate: (i) the effect of different classes of emulsifiers on markers of intestinal inflammation in mice and (ii) the…
View article: Fibre from nopal cactus (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a pilot randomised-controlled trial
Fibre from nopal cactus (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a pilot randomised-controlled trial Open
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View article: Prebiotic β-galacto-oligosaccharide impact on clinical, inflammatory and microbiota outcomes in active ulcerative colitis: an open-label study
Prebiotic β-galacto-oligosaccharide impact on clinical, inflammatory and microbiota outcomes in active ulcerative colitis: an open-label study Open
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View article: Nutrition: An old science in a new microbial light
Nutrition: An old science in a new microbial light Open
Knowledge of the gut microbiota is revolutionising what it means to be human. Indeed, an altered gut microbiota, often referred to as dysbiosis, has been observed in over 70 chronic diseases (Rojo et al. 2017). Although for most conditions…
View article: Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease
Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease Open
Fermented foods are defined as foods or beverages produced through controlled microbial growth, and the conversion of food components through enzymatic action. In recent years, fermented foods have undergone a surge in popularity, mainly d…
View article: Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials
Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials Open
Prebiotics do not improve gastrointestinal symptoms or QoL in patients with IBS or other FBDs, but they do increase bifidobacteria. Variations in prebiotic type and dose impacted symptom improvement or exacerbation. This review was registe…
View article: PWE-126 Low fodmap diet effect on IBS gastrointestinal microbiome and metabolites and prediction of response
PWE-126 Low fodmap diet effect on IBS gastrointestinal microbiome and metabolites and prediction of response Open
Introduction Prebiotic β-galactooligosaccharides (B-GOS) may counteract the microbiome modifying effect of the low FODMAP diet (LFD) in patients with irritable bowel syndrome (IBS). Faecal metabolites may predict why only some patients res…
View article: Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis Open
Dietary fiber intervention, particularly involving fructans and galacto-oligosaccharides, leads to higher fecal abundance of Bifidobacterium and Lactobacillus spp. but does not affect α-diversity. Further research is required to better und…
View article: Volatile Organic Compounds in Feces Associate With Response to Dietary Intervention in Patients With Irritable Bowel Syndrome
Volatile Organic Compounds in Feces Associate With Response to Dietary Intervention in Patients With Irritable Bowel Syndrome Open
Fecal VOC profiling is a low cost, non-invasive tool that might be used to predict responses of patients with IBS to low-FODMAP diet and probiotics and identify their mechanisms of action. ISRCTN registry no: 02275221.
View article: Irritable bowel syndrome and diet
Irritable bowel syndrome and diet Open
It is clear that a low FODMAP diet has a beneficial effect in a majority of patients with IBS. Probiotics also have great potential in the management of IBS; however, it is still unclear which strains and doses are the most beneficial. Fur…
View article: Volatile organic compounds predict response to both low FODMAP diet and probiotics in irritable bowel syndrome: a randomised controlled trial
Volatile organic compounds predict response to both low FODMAP diet and probiotics in irritable bowel syndrome: a randomised controlled trial Open
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View article: Prebiotic B-Galacto-oligasaccharide supplementation of the low FODMAP diet improves symptoms of irritable bowel syndrome but does not prevent diet induced decline in bifidobacteria: a randomised controlled trial
Prebiotic B-Galacto-oligasaccharide supplementation of the low FODMAP diet improves symptoms of irritable bowel syndrome but does not prevent diet induced decline in bifidobacteria: a randomised controlled trial Open
Prebiotic B-Galacto-oligasaccharide supplementation of the low FODMAP diet improves symptoms of irritable bowel syndrome but does not prevent diet induced decline in bifidobacteria: a randomised controlled trial - Volume 76 Issue OCE4
View article: Excess protein intake relative to fiber and cardiovascular events in elderly men with chronic kidney disease
Excess protein intake relative to fiber and cardiovascular events in elderly men with chronic kidney disease Open
An excess of dietary protein relative to fiber intake was associated with the incidence of cardiovascular events in a homogeneous population of older men with CKD.
View article: Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY)
Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY) Open
In patients with CKD, synbiotics did not significantly reduce serum IS but did decrease serum PCS and favorably modified the stool microbiome. Large-scale clinical trials are justified.