Megan Skelton
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View article: Genome-wide insights into generalised anxiety using a dimensional symptom severity approach
Genome-wide insights into generalised anxiety using a dimensional symptom severity approach Open
We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of w…
View article: Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder
Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder Open
Introductory paragraph Panic attacks, sudden episodes of intense fear accompanied by physical and psychological symptoms, affect approximately 23% of the population 1,2 . Panic disorder, diagnosed in 2– 4% 3 , involves recurrent attacks fo…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: The UK Biobank mental health enhancement 2022: Methods and results
The UK Biobank mental health enhancement 2022: Methods and results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…
View article: Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood
Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood Open
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: Trajectories of conduct problems: exploring genetic and early-life risk factors and adult outcomes
Trajectories of conduct problems: exploring genetic and early-life risk factors and adult outcomes Open
Background: Conduct problems trajectory studies suggest their development is highly heterogeneous and that different trajectories may be uniquely associated with different risk factors and outcomes. Yet studies combining trajectory modelli…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairme…
View article: The UK Biobank Mental Health Enhancement 2022: Methods and Results
The UK Biobank Mental Health Enhancement 2022: Methods and Results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40-…
View article: Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome
Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome Open
Despite the widespread use of cognitive-behavioural therapy (CBT), only about half of patients respond favourably. Understanding whether relevant psychological processes are associated with treatment response could help identify patients a…
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: The genetic overlap between functional impairment and severity of depression and anxiety symptoms
The genetic overlap between functional impairment and severity of depression and anxiety symptoms Open
Background Impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence suggesting that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: The United Kingdom Eating Disorders Genetics Initiative
The United Kingdom Eating Disorders Genetics Initiative Open
Objective The United Kingdom Eating Disorders Genetics Initiative (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic et…
View article: Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy
Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy Open
Underlying classes capture differences between patient symptom trajectories during psychological therapy. This has not been explored for one-to-one internet-delivered therapy or functional impairment trajectories. Patients experiencing dep…
View article: Trajectories of depression and anxiety symptom severity during psychological therapy for common mental health problems
Trajectories of depression and anxiety symptom severity during psychological therapy for common mental health problems Open
Background There is substantial variation in patient symptoms following psychological therapy for depression and anxiety. However, reliance on endpoint outcomes ignores additional interindividual variation during therapy. Knowing a patient…
View article: Factors associated with anxiety disorder comorbidity
Factors associated with anxiety disorder comorbidity Open
View article: Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants
Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants Open
View article: The Eating Disorders Genetics Initiative (EDGI) United Kingdom
The Eating Disorders Genetics Initiative (EDGI) United Kingdom Open
Objective The Eating Disorders Genetics Initiative United Kingdom (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic ae…
View article: Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy
Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy Open
Background: Underlying classes can capture differences between patient symptom trajectories during in-person psychological therapy. These classes show associations with baseline variables, which could be used at the start of treatment to i…
View article: Genetic and early environmental predictors of adulthood self-reports of trauma
Genetic and early environmental predictors of adulthood self-reports of trauma Open
Background Retrospective self-reports of childhood trauma are associated with a greater risk of psychopathology in adulthood than prospective measures of trauma. Heritable reporter characteristics are anticipated to account for part of thi…
View article: Life events and treatment prognosis for depression: A systematic review and individual patient data meta-analysis
Life events and treatment prognosis for depression: A systematic review and individual patient data meta-analysis Open
View article: Trajectories of depression and anxiety symptoms during psychological therapy for common mental health problems
Trajectories of depression and anxiety symptoms during psychological therapy for common mental health problems Open
Background: There is substantial variation in patient symptoms following psychological therapy for depression and anxiety. However, reliance on endpoint outcomes ignores additional interindividual variation during therapy. Knowing a patien…
View article: Sociodemographic factors associated with treatment-seeking and treatment receipt: cross-sectional analysis of UK Biobank participants with lifetime generalised anxiety or major depressive disorder
Sociodemographic factors associated with treatment-seeking and treatment receipt: cross-sectional analysis of UK Biobank participants with lifetime generalised anxiety or major depressive disorder Open
Background Anxiety and depressive disorders can be chronic and disabling. Although there are effective treatments, only a fraction of those impaired receive treatment. Predictors of treatment-seeking and treatment receipt could be informat…
View article: Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts
Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts Open
View article: Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms
Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms Open
Significant age and sex variability suggest that classic diagnostic criteria reflect the presentation most commonly seen in younger males. This study provides avenues for diagnostic adaptation and factor-specific interventions.
View article: <scp>Self‐reported</scp> medication use as an alternate phenotyping method for anxiety and depression in the <scp>UK</scp> Biobank
<span>Self‐reported</span> medication use as an alternate phenotyping method for anxiety and depression in the <span>UK</span> Biobank Open
The requirement for large sample sizes for psychiatric genetic analyses necessitates novel approaches to derive cases. Anxiety and depression show substantial genetic overlap and share pharmacological treatments. Data on prescribed medicat…
View article: Comparison of depression and anxiety symptom networks in reporters and non-reporters of lifetime trauma in two samples of differing severity
Comparison of depression and anxiety symptom networks in reporters and non-reporters of lifetime trauma in two samples of differing severity Open
Reported lifetime trauma was associated with stronger interactions between symptoms of depression and anxiety in population volunteers. Differences between reporters and non-reporters may not be observed in individuals with severe depressi…