Megan U. Carnes
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View article: Common data elements to advance ME/CFS research
Common data elements to advance ME/CFS research Open
Common data elements to advance ME/CFS research Standardizing data collection in ME/CFS research through Common Data Elements is a crucial step toward improving diagnosis, advancing treatments, and fostering collaboration across studies to…
View article: Association of catechol-O-methyltransferase genetic polymorphism with neuromodulation treatment response in women with fecal or urinary incontinence
Association of catechol-O-methyltransferase genetic polymorphism with neuromodulation treatment response in women with fecal or urinary incontinence Open
View article: Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci
Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci Open
View article: Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases
Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases Open
Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting…
View article: Urinary microbiome community types associated with urinary incontinence severity in women
Urinary microbiome community types associated with urinary incontinence severity in women Open
View article: Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci
Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci Open
Smoking is a leading cause of preventable morbidity and mortality. Smoking is heritable, and genome-wide association studies (GWAS) of smoking behaviors have identified hundreds of significant loci. Most GWAS-identified variants are noncod…
View article: How can data management tools help us discover new treatments for a chronic disease?
How can data management tools help us discover new treatments for a chronic disease? Open
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that can take a huge toll on a person's everyday life.There is still much we do not know about the disease, and researchers are working hard to learn more abo…
View article: mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites
mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites Open
View article: Association between the urogenital microbiome and surgical treatment response in women undergoing midurethral sling operation for mixed urinary incontinence
Association between the urogenital microbiome and surgical treatment response in women undergoing midurethral sling operation for mixed urinary incontinence Open
View article: mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites
mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites Open
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease which involves multiple body systems (e.g., immune, nervous, digestive, circulatory) and research domains (e.g., immunology, metabolomics, the…
View article: Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits Open
View article: Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers
Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers Open
View article: House dust microbiota in relation to adult asthma and atopy in a US farming population
House dust microbiota in relation to adult asthma and atopy in a US farming population Open
View article: Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium
Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium Open
Cigarette smoking is the leading cause of preventable morbidity and mortality. Knowledge is evolving on genetics underlying initiation, regular smoking, nicotine dependence (ND), and cessation. We performed a genome-wide association study …
View article: Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults
Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults Open
View article: Additional file 3: of Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults
Additional file 3: of Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults Open
Table S9. Differential methylation in relation to PM10 exposure. Table S10. Differential methylation in relation to NO2 exposure (XLSX 46770 kb)
View article: Additional file 2: of Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults
Additional file 2: of Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults Open
Table S1. CpG probe filtering criteria in the 450 K array. Table S2. CpGs included in the top five differentially methylated regions in relation to PM10 from each analysis: DMRcate and comb-p (ordered by software and chromosomal location).…
View article: Exposures Related to House Dust Microbiota in a U.S. Farming Population
Exposures Related to House Dust Microbiota in a U.S. Farming Population Open
In this farming population, house dust microbiota differed by current farming status. Understanding the determinants of the indoor microbiota is the first step toward understanding potential relationships with health outcomes. https://doi.…
View article: Sleep apnea and pesticide exposure in a study of US farmers
Sleep apnea and pesticide exposure in a study of US farmers Open
View article: House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies
House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies Open
This is, to our knowledge, the first report of an association between house dust endotoxin and leukocyte count in a national survey. The finding was replicated in a farming population. Peripheral leukocyte count may be influenced by reside…
View article: House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population
House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population Open
House dust endotoxin was associated with current atopic and nonatopic asthma in a U.S. farming population. The degree of the association with asthma depended on early-life farm exposures. Furthermore, endotoxin was associated with lower pu…
View article: The Genomic Basis of Postponed Senescence in Drosophila melanogaster
The Genomic Basis of Postponed Senescence in Drosophila melanogaster Open
Natural populations harbor considerable genetic variation for lifespan. While evolutionary theory provides general explanations for the existence of this variation, our knowledge of the genes harboring naturally occurring polymorphisms aff…