Meghan A. Wynosky-Dolfi
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View article: TLR priming licenses NAIP inflammasome activation by immunoevasive ligands
TLR priming licenses NAIP inflammasome activation by immunoevasive ligands Open
NLR family, apoptosis inhibitory proteins (NAIPs) detect bacterial flagellin and structurally related components of bacterial type III secretion systems (T3SS), and recruit NLR family CARD domain containing protein 4 (NLRC4) and caspase-1 …
View article: Gasdermins assemble; recent developments in bacteriology and pharmacology
Gasdermins assemble; recent developments in bacteriology and pharmacology Open
The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight. In its purest form, GSDMD pro…
View article: TLR priming licenses NAIP inflammasome activation by immunoevasive ligands
TLR priming licenses NAIP inflammasome activation by immunoevasive ligands Open
NLR family, apoptosis inhibitory proteins (NAIPs) detect bacterial flagellin and structurally related components of bacterial type III secretion systems (T3SS), and recruit NLR family, CARD domain containing protein 4 (NLRC4) and caspase-1…
View article: Arresting microbiome development limits immune system maturation and resistance to infection in mice
Arresting microbiome development limits immune system maturation and resistance to infection in mice Open
View article: Arresting microbiome development limits immune system maturation and resistance to infection
Arresting microbiome development limits immune system maturation and resistance to infection Open
Disruptions to the intestinal microbiome during weaning lead to long-term negative effects on host immune function. However, the critical host-microbe interactions occurring during weaning required for healthy immune system development rem…
View article: Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection Open
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokin…
View article: Genetic targeting of<i>Card19</i>is linked to disrupted<i>Ninj1 expression</i>, impaired cell lysis, and increased susceptibility to<i>Yersinia</i>infection
Genetic targeting of<i>Card19</i>is linked to disrupted<i>Ninj1 expression</i>, impaired cell lysis, and increased susceptibility to<i>Yersinia</i>infection Open
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokin…
View article: Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against <i>Toxoplasma gondii</i>
Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against <i>Toxoplasma gondii</i> Open
Caspase-8 is a key integrator of cell survival and cell death decisions during infection and inflammation. Following engagement of tumor necrosis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-…
View article: Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation Open
View article: A Nonpyroptotic IFN-γ–Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes <i>Salmonella</i> Clearance In Vivo
A Nonpyroptotic IFN-γ–Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes <i>Salmonella</i> Clearance In Vivo Open
The cytokine IFN-γ has well-established antibacterial properties against the bacterium Salmonella enterica in phagocytes, but less is known about the effects of IFN-γ on Salmonella-infected nonphagocytic cells, such as intestinal epithelia…
View article: Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity
Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity Open
Bacterial pathogens that compromise phagosomal membranes stimulate inflammasome assembly in the cytosol, but the molecular mechanisms by which membrane dynamics regulate inflammasome activity are poorly characterized. We show that in murin…
View article: RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense
RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense Open
Many pathogens deliver virulence factors or effectors into host cells in order to evade host defenses and establish infection. Although such effector proteins disrupt critical cellular signaling pathways, they also trigger specific antipat…
View article: Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death
Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death Open
Caspases regulate cell death programs in response to environmental stresses, including infection and inflammation, and are therefore critical for the proper operation of the mammalian immune system. Caspase-8 is necessary for optimal produ…
View article: Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD
Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD Open
Type III secretion systems (T3SS) translocate effector proteins into target cells in order to disrupt or modulate host cell signaling pathways and establish replicative niches. However, recognition of T3SS activity by cytosolic pattern rec…