Meghan E. Wynne
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View article: Spatially patterned cytoskeletal organization shapes astrocyte branch complexity
Spatially patterned cytoskeletal organization shapes astrocyte branch complexity Open
Astrocytes, the most abundant cells in the brain, extend elaborate branches that enable diverse functions, from synapse maintenance to blood-brain-barrier integrity. The cytoskeletal basis of this architecture has remained unclear, since t…
View article: A genetic and proteomic approach to understanding neuropsychiatric symptoms in ADRD
A genetic and proteomic approach to understanding neuropsychiatric symptoms in ADRD Open
Background Three lines of epidemiologic evidence link several psychiatric disorders to ADRD. First, experiencing schizophrenia or a mood/anxiety disorder in early/mid‐adulthood increases the risk of developing dementia by 6‐folds. Second, …
View article: APOE expression and secretion are modulated by mitochondrial dysfunction
APOE expression and secretion are modulated by mitochondrial dysfunction Open
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more ex…
View article: Author response: APOE expression and secretion are modulated by mitochondrial dysfunction
Author response: APOE expression and secretion are modulated by mitochondrial dysfunction Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mitocho…
View article: Shared mechanisms across the major psychiatric and neurodegenerative diseases
Shared mechanisms across the major psychiatric and neurodegenerative diseases Open
Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation. Using 25 GWAS results and LD score regression, we find eight …
View article: APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction
APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction Open
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more ex…
View article: Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus
Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus Open
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurod…
View article: Heterogeneous Expression of Nuclear Encoded Mitochondrial Genes Distinguishes Inhibitory and Excitatory Neurons
Heterogeneous Expression of Nuclear Encoded Mitochondrial Genes Distinguishes Inhibitory and Excitatory Neurons Open
Mitochondrial composition varies by organ and their constituent cell types. This mitochondrial diversity likely determines variations in mitochondrial function. However, the heterogeneity of mitochondria in the brain remains underexplored …
View article: Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus that are Necessary for Synapse Function
Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus that are Necessary for Synapse Function Open
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurod…
View article: Molecular Systems Biology of Neurodevelopmental Disorders, Rett Syndrome as an Archetype
Molecular Systems Biology of Neurodevelopmental Disorders, Rett Syndrome as an Archetype Open
Neurodevelopmental disorders represent a challenging biological and medical problem due to their genetic and phenotypic complexity. In many cases, we lack the comprehensive understanding of disease mechanisms necessary for targeted therape…