Meghan M. Capeling
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View article: Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution Open
The intestinal epithelium is often a site of pathology, such as in inflammatory bowel disease (IBD), and its maintenance is highly modulated by interactions with the microenvironment. However, a systematic understanding of how the myriad o…
View article: Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model
Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model Open
View article: EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids
EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids Open
Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development. Here, we interrogated the cell si…
View article: A human liver organoid screening platform for DILI risk prediction
A human liver organoid screening platform for DILI risk prediction Open
View article: Additional file 1 of Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model
Additional file 1 of Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model Open
Supplementary Material 1
View article: Organoids as tools for fundamental discovery and translation—a Keystone Symposia report
Organoids as tools for fundamental discovery and translation—a Keystone Symposia report Open
Complex three‐dimensional in vitro organ‐like models, or organoids, offer a unique biological tool with distinct advantages over two‐dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex…
View article: Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model
Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model Open
MicroRNAs (miRNAs) are important post-transcriptional gene regulators in organ development. To explore candidate roles for miRNAs in prenatal SI lineage specification in humans, we used a multi-omic analysis strategy in a directed differen…
View article: A Development-Inspired Niche for Homeostatic Human Mini-Intestines
A Development-Inspired Niche for Homeostatic Human Mini-Intestines Open
Summary Epithelial organoids derived from intestinal tissue, also referred to as mini-intestines or mini-guts, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug develo…
View article: Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation
Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation Open
View article: Suspension culture promotes serosal mesothelial development in human intestinal organoids
Suspension culture promotes serosal mesothelial development in human intestinal organoids Open
View article: Defined Culture Environments Create an Improved Human Intestinal Organoid Model System to Study Intestinal Development
Defined Culture Environments Create an Improved Human Intestinal Organoid Model System to Study Intestinal Development Open
Organoids are small, stem cell-derived culture systems that mimic aspects of the structure and function of the organs they are modelled after. Thus, organoids provide a 3D model for studying human development and disease in a complex human…
View article: A Human Liver Organoid Screening Platform for DILI Risk Prediction
A Human Liver Organoid Screening Platform for DILI Risk Prediction Open
Background and Aims Drug-induced liver injury (DILI), both intrinsic and idiosyncratic, causes frequent morbidity, mortality, clinical trial failures and post-approval withdrawal. This suggests an unmet need for improved in vitro models fo…
View article: Charting human development using a multi-endodermal organ atlas and organoid models
Charting human development using a multi-endodermal organ atlas and organoid models Open
View article: Charting human development using a multi-organ atlas and organoid models
Charting human development using a multi-organ atlas and organoid models Open
Organs are composed of diverse cell types, which traverse transient states during organogenesis. To interrogate this diversity during human development, we generate a single-cell transcriptome atlas from multiple developing endodermal orga…
View article: Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells
Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells Open
View article: Differentiation of human intestinal organoids with endogenous vascular endothelial cells
Differentiation of human intestinal organoids with endogenous vascular endothelial cells Open
SUMMARY Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) generated using directed differentiation lack some cellular populations found in the native organ, including vasculature. Using single cell RNA sequencing (scRN…
View article: Biologically inspired approaches to enhance human organoid complexity
Biologically inspired approaches to enhance human organoid complexity Open
Organoids are complex three-dimensional in vitro organ-like model systems. Human organoids, which are derived from human pluripotent stem cells or primary human donor tissue, have been used to address fundamental questions about human deve…
View article: Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids
Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids Open
Human intestinal organoids (HIOs) represent a powerful system to study human development and are promising candidates for clinical translation as drug-screening tools or engineered tissue. Experimental control and clinical use of HIOs is l…
View article: Non-adhesive alginate hydrogels support growth of pluripotent stem cell-derived intestinal organoids
Non-adhesive alginate hydrogels support growth of pluripotent stem cell-derived intestinal organoids Open
Summary Human intestinal organoids (HIOs) represent a powerful system to study human development and are promising candidates for clinical translation as drug-screening tools or engineered tissue. Experimental control and clinical use of H…
View article: Biodegradable zwitterionic sulfobetaine polymer and its conjugate with paclitaxel for sustained drug delivery
Biodegradable zwitterionic sulfobetaine polymer and its conjugate with paclitaxel for sustained drug delivery Open