Mehak Kanwar
YOU?
Author Swipe
View article: Simultaneous blockade of TLR4 and TNFR1 attenuates TLR2 sensitivity in LPS-stimulated macrophages through TNFR2-mediated pathway
Simultaneous blockade of TLR4 and TNFR1 attenuates TLR2 sensitivity in LPS-stimulated macrophages through TNFR2-mediated pathway Open
Background: Recent studies have found TLR2 to be a significant player in initiating immune responses in the host during bacterial infection. Macrophage polarization is one of the vital factors in the amelioration of sepsis. It is well esta…
View article: Global conserved RBD fraction of SARS-CoV-2 S-protein with T500S mutation in silico significantly blocks ACE2 and rejects viral spike
Global conserved RBD fraction of SARS-CoV-2 S-protein with T500S mutation in silico significantly blocks ACE2 and rejects viral spike Open
Background SARS-CoV-2 developed global-pandemic with millions of infections/deaths. As it is urgently necessary it is assumed that some blockers/inhibitors of ACE2 could be helpful to resist the binding of viral-spike Receptor-Binding-Doma…
View article: In-silico study of Hesperidin, Epigallocatechin (EGCG ), Kaempferol and Quercetin
In-silico study of Hesperidin, Epigallocatechin (EGCG ), Kaempferol and Quercetin Open
SARS-Cov-2 or COVID-19 has caused a global disaster and catastrophe which has consequently led to a pandemic for the last two decades, the world has faced coronaviruses similar to SARS-Cov-2 such as SARS-Cov and Mers-Cov. In this study, a …
View article: Conserved in 186 countries the RBD fraction of SARS CoV-2 S-protein with in-silicoT500S mutation strongly blocks ACE2 rejecting the viral spike; A Molecular-docking analysis
Conserved in 186 countries the RBD fraction of SARS CoV-2 S-protein with in-silicoT500S mutation strongly blocks ACE2 rejecting the viral spike; A Molecular-docking analysis Open
SARS-CoV-2 developed global-pandemic with millions of infections/deaths. Blocker/inhibitor of ACE2 and viral-spikes Receptor-Binding-Domain RBD-blockers are helpful. Here, conserved RBD (CUTs) from 186-countries were compared with WUHAN-Hu…
View article: Immunoinformatic Responses of Host MHC I/II and CD4+ Cells Against Conserved Spike Fragments of SARS CoV-2 of 186 Countries With In-Silico Mutations: Implications in Universal Vaccination
Immunoinformatic Responses of Host MHC I/II and CD4+ Cells Against Conserved Spike Fragments of SARS CoV-2 of 186 Countries With In-Silico Mutations: Implications in Universal Vaccination Open
Different types of quickly-developed vaccines have been introduced against Covid-19 with largely inconclusive results. On the course of time, somewhere Covid-19 declines its infection/mortality rate and in some countries it revived with so…
View article: Conserved in 186 Countries The RBD Fraction of SARS CoV-2 S-Protein With in-Silico T500S Mutation Strongly Blocks ACE2 Rejecting The Viral Spike; A Molecular-Docking Analysis.
Conserved in 186 Countries The RBD Fraction of SARS CoV-2 S-Protein With in-Silico T500S Mutation Strongly Blocks ACE2 Rejecting The Viral Spike; A Molecular-Docking Analysis. Open
SARS CoV-2 developed a global pandemic with millions of infections/deaths. The role of blocker/inhibitor of ACE2 and viral-spikes Receptor-Binding-Domain RBD-blockers has been reported. In the current study, conserved RBD portions or cuts …
View article: Active-site Molecular docking of Nigellidine to nucleocapsid/Nsp2/Nsp3/MPro of COVID-19 and to human IL1R and TNFR1/2 may stop viral-growth/cytokine-flood, and the drug source Nigella sativa (black cumin) seeds show potent antioxidant role in experimental rats.
Active-site Molecular docking of Nigellidine to nucleocapsid/Nsp2/Nsp3/MPro of COVID-19 and to human IL1R and TNFR1/2 may stop viral-growth/cytokine-flood, and the drug source Nigella sativa (black cumin) seeds show potent antioxidant role in experimental rats. Open
The recent outbreak of SARS CoV-2 has changed the global scenario of human lives and economy. In this pandemic-outbreak the ratio of infected person is much higher than the death encountered. Most of the dead patients were observed with dy…