Mohammad Afzal
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View article: Insights into Communication Differences of ASD Children and their Parents’ Emotional State
Insights into Communication Differences of ASD Children and their Parents’ Emotional State Open
This paper examines how the emotional health of parents is affected by communication differences between their autistic children. The research conducted qualitative thematic analysis on interviews with parents of autistic children to find …
View article: Structural dynamics of dengue virus during human-to-human transmission mediated by mosquito vectors
Structural dynamics of dengue virus during human-to-human transmission mediated by mosquito vectors Open
This review explores the structural dynamics of Dengue virus (DENV) during human-to-human transmission mediated by mosquito vectors, primarily Aedes aegypti. DENV remains a global health concern, with increasing cases due to climate change…
View article: Reimagining the Gothic Genre in Postmodern Literature Themes of Isolation, Technology, and Decay
Reimagining the Gothic Genre in Postmodern Literature Themes of Isolation, Technology, and Decay Open
This paper examined the way the postmodern literature has in effect reinterpreted Gothic form by incorporating an element of isolation, technology and decay to echo on modern anxieties. According to the results obtained after analyzing the…
View article: The role of platelet transfusion in modulating platelet indices and leukocyte dynamics in dengue fever patients
The role of platelet transfusion in modulating platelet indices and leukocyte dynamics in dengue fever patients Open
Dengue fever, a viral illness transmitted by Aedes mosquitoes, is marked by a reduction in platelet count (PLT) and changes in blood parameters, which increase the risk of complications such as hemorrhage. Platelet transfusion is frequentl…
View article: Oxidative stress and inflammatory pathways in sickle cell anemia: Diagnostic and therapeutic insights
Oxidative stress and inflammatory pathways in sickle cell anemia: Diagnostic and therapeutic insights Open
Sickle cell anemia (SCA) is a genetic hemoglobinopathy marked by persistent hemolysis, vaso-occlusion, and many organ problems. Oxidative stress and inflammation are crucial in the pathophysiology of SCA, contributing significantly to dise…
View article: Evaluating anti-CHIK IgM and qualitative RT-PCR for diagnosing chikungunya in hospitalized patients: A comparative analysis of diagnostic efficacy
Evaluating anti-CHIK IgM and qualitative RT-PCR for diagnosing chikungunya in hospitalized patients: A comparative analysis of diagnostic efficacy Open
Background & objectives: Chikungunya virus (CHIKV) is an alphavirus characterized by a positive-sense, single-stranded RNA genome, and it is transmitted primarily by Aedes mosquitoes. Prompt and precise diagnosis is essential for efficient…
View article: Strategies to decolonize uropathogens in urethra and bladder for prevention of urinary tract infections among pregnant women: A comprehensive narrative analysis
Strategies to decolonize uropathogens in urethra and bladder for prevention of urinary tract infections among pregnant women: A comprehensive narrative analysis Open
Urinary tract infections (UTIs) are frequent among pregnant women and can cause difficulties for both mother and fetus. Uropathogens that colonize the urethra and bladder are significant contributors to UTIs during pregnancy. Preventive me…
View article: Advancements in the treatment of autoimmune diseases: Integrating artificial intelligence for personalized medicine
Advancements in the treatment of autoimmune diseases: Integrating artificial intelligence for personalized medicine Open
The incorporation of artificial intelligence (AI) into medical practice has considerably improved the treatment of autoimmune disorders, opening new avenues for personalized therapy. This study examines advances in AI-driven therapeutic op…
View article: A Diagnostic Study Using STARD Platform on Liquid-Based Cytology in Cervical Smear and Its Positivity Rate among Females with Abnormal Vaginal Conditions Attending a Tertiary Care Center
A Diagnostic Study Using STARD Platform on Liquid-Based Cytology in Cervical Smear and Its Positivity Rate among Females with Abnormal Vaginal Conditions Attending a Tertiary Care Center Open
Background: Liquid-based cytology (LBC) is a newer method of preparing cervical cell samples. This technique involves collecting cells in a liquid fixative and preparing and evaluating them. Aim: This study aims to investigate cervical sme…
View article: Assessment of inbreeding depression on morphometric traits among North Indian population cohorts
Assessment of inbreeding depression on morphometric traits among North Indian population cohorts Open
Aim Inbreeding is thought to affect the morphometric parameters leading to lower health status among the progeny. The present study was aimed to investigate the repercussions of inbreeding on anthropometric traits, namely height, weight an…
View article: Dengue dynamics: Prognostic and disease monitoring through molecular and serological profiling of clinical isolates
Dengue dynamics: Prognostic and disease monitoring through molecular and serological profiling of clinical isolates Open
Background & objectives: Dengue fever is a mosquito-bome illness that affects millions of people worldwide every year. With no vaccination available, early detection and treatment are critical. It is found in 112 countries and poses a risk…
View article: Exploring the Diagnostic and Therapeutic Significance of Thyroid Hormones in Female Infertility: A Comprehensive Narrative Review
Exploring the Diagnostic and Therapeutic Significance of Thyroid Hormones in Female Infertility: A Comprehensive Narrative Review Open
Thyroid Hormones (TH) are essential for the healthy functioning of the female reproductive system because they regulate ovarian, uterine, and placental tissue metabolism and development. Therefore, hypo-and hyperthyroidism may result in in…
View article: The Molecular Blueprint for Chronic Obstructive Pulmonary Disease (COPD): A New Paradigm for Diagnosis and Therapeutics
The Molecular Blueprint for Chronic Obstructive Pulmonary Disease (COPD): A New Paradigm for Diagnosis and Therapeutics Open
The global prevalence of chronic obstructive pulmonary disease (COPD) has increased over the last decade and has emerged as the third leading cause of death worldwide. It is characterized by emphysema with prolonged airflow limitation. COP…
View article: Idiopathic pulmonary fibrosis: Pathophysiology, cellular signaling, diagnostic and therapeutic approaches
Idiopathic pulmonary fibrosis: Pathophysiology, cellular signaling, diagnostic and therapeutic approaches Open
Idiopathic pulmonary fibrosis (IPF) is a life-threatening and progressive interstitial lung disease. Healthy pulmonary tissues were replaced by an altered extracellular matrix (ECM) and destroyed the alveolar architecture, which led to the…
View article: Effectiveness of modified Manchester triage flow model regarding patients’ waiting time
Effectiveness of modified Manchester triage flow model regarding patients’ waiting time Open
Triage is a French word meaning to sort or to choose. Triage is therefore a process whereby each patient is prioritized amongst the randomly approaching patients in the Accident & Emergency Department/rescue area for emergency care ( Zacha…
View article: A Comprehensive Review of miRNAs and Their Epigenetic Effects in Glioblastoma
A Comprehensive Review of miRNAs and Their Epigenetic Effects in Glioblastoma Open
Glioblastoma is the most aggressive form of brain tumor originating from glial cells with a maximum life expectancy of 14.6 months. Despite the establishment of multiple promising therapies, the clinical outcome of glioblastoma patients is…
View article: Genetic association analysis of rs662799 ( − 1131A > G) polymorphism of APOA5 gene with morphometric and physio-metric traits using multiplex PCR
Genetic association analysis of rs662799 ( − 1131A > G) polymorphism of APOA5 gene with morphometric and physio-metric traits using multiplex PCR Open
Background The apolipoprotein A5 ( APOA5 ) gene, significantly expressed in liver, has been involved in regulation of triglyceride metabolism, plasma lipid levels, serum adipokine levels and cardiovascular traits. A single-nucleotide polym…
View article: Association of BDNF gene missense polymorphism rs6265 (Val66Met) with three quantitative traits, namely, intelligence quotient, body mass index, and blood pressure: A genetic association analysis from North India
Association of BDNF gene missense polymorphism rs6265 (Val66Met) with three quantitative traits, namely, intelligence quotient, body mass index, and blood pressure: A genetic association analysis from North India Open
Background Brain-derived neurotrophic factor (BDNF), a neurotransmitter modulator, plays a significant role in neuronal survival and growth and participates in neuronal plasticity, thus being essential for learning, memory, and the develop…
View article: Direct sequencing of β-globin gene reveals a rare combination of two exonic and two intronic variants in a β-thalassemia major patient: a case report
Direct sequencing of β-globin gene reveals a rare combination of two exonic and two intronic variants in a β-thalassemia major patient: a case report Open
Background Due to indels in the β-globin gene, patients with β-thalassemia major exhibit a range of severity, with genotype β 0 β 0 > β 0 β + > β + β + , according to the production level of the β-globin chain. More than 300 mutations have…
View article: Beta‐thalassemia and the advent of new interventions beyond transfusion and iron chelation
Beta‐thalassemia and the advent of new interventions beyond transfusion and iron chelation Open
Beta‐thalassaemia, including sickle cell anaemia and thalassaemia E, is most common in developing countries in tropical and subtropic regions. Because carriers have migrated there owing to demographic migration, β‐thalassaemia can now be d…
View article: A Hospital-based Survey on the Pattern of Ocular Diseases in Western Uttar Pradesh, India
A Hospital-based Survey on the Pattern of Ocular Diseases in Western Uttar Pradesh, India Open
Aims and Objectives: Ocular morbidities involve a spectrum of eye diseases that affect one’s quality of life. Therefore, in view of the importance of visual impairment and lack of precise information, the study was conducted to determine t…
View article: Cataloging the potential SNPs (single nucleotide polymorphisms) associated with quantitative traits, viz. BMI (body mass index), IQ (intelligence quotient) and BP (blood pressure): an updated review
Cataloging the potential SNPs (single nucleotide polymorphisms) associated with quantitative traits, viz. BMI (body mass index), IQ (intelligence quotient) and BP (blood pressure): an updated review Open
Background Single nucleotide polymorphism (SNP) variants are abundant, persistent and widely distributed across the genome and are frequently linked to the development of genetic diseases. Identifying SNPs that underpin complex diseases ca…
View article: Burden and quality of life in caregivers of obsessive-compulsive disorder and schizophrenia: a case-controlled study
Burden and quality of life in caregivers of obsessive-compulsive disorder and schizophrenia: a case-controlled study Open
Background: Obsessive–compulsive disorder (OCD) and schizophrenia both are chronic and disabling mental illness which imposes considerable burden on caregivers. Many studies have also reported that both of them have a negative impact on th…
View article: Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency in Aligarh, India: A Pilot Study
Prevalence of Glucose-6-phosphate Dehydrogenase Deficiency in Aligarh, India: A Pilot Study Open
Introduction: Deficiency of glucose-6-phosphate dehydrogenase (G6PD) enzyme in erythrocytes is among the prevalent X-linked recessive genetic disorders and affects approximately 400 million people across the globe. It causes neonatal hyper…