Mehar Chand Sharma
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View article: PTHP-10. Unveiling Adult-Type Gliomas in Pediatric and AYA Patients: Insights from Methylation Profiling
PTHP-10. Unveiling Adult-Type Gliomas in Pediatric and AYA Patients: Insights from Methylation Profiling Open
High grade gliomas (HGGs) in pediatric and adolescent/young adult (AYA) patients are typically classified as pediatric type tumors. However, emerging evidence challenges this age-based dichotomy, with some tumors in younger individuals exh…
View article: Acute Hemorrhagic Leukoencephalitis With Active Hepatitis B Virus Infection
Acute Hemorrhagic Leukoencephalitis With Active Hepatitis B Virus Infection Open
CNS involvement in hepatitis B virus (HBV) infection is rare. We report a 27-year-old woman with HBV infection presenting with headaches and seizures, whose imaging and brain biopsy confirmed acute hemorrhagic leukoencephalitis. She respon…
View article: P10.07.B ADVANCING DIAGNOSTIC CRITERIA AND CLINICAL INSIGHTS IN PEDIATRIC HIGH-GRADE GLIOMAS, H3 WILDTYPE AND IDH WILDTYPE
P10.07.B ADVANCING DIAGNOSTIC CRITERIA AND CLINICAL INSIGHTS IN PEDIATRIC HIGH-GRADE GLIOMAS, H3 WILDTYPE AND IDH WILDTYPE Open
BACKGROUND Diffuse pediatric-type high-grade gliomas, characterised by H3 wildtype and IDH wildtype status, represent a recently recognised and highly aggressive brain tumour entity with distinct molecular and epigenetic signatures. Althou…
View article: P10.22.A UNRAVELLING MOLECULAR HETEROGENEITY IN DIFFUSE HIGH-GRADE GLIOMAS OF PEDIATRIC, ADOLESCENT, AND YOUNG ADULTS THROUGH DNA METHYLATION PROFILING
P10.22.A UNRAVELLING MOLECULAR HETEROGENEITY IN DIFFUSE HIGH-GRADE GLIOMAS OF PEDIATRIC, ADOLESCENT, AND YOUNG ADULTS THROUGH DNA METHYLATION PROFILING Open
BACKGROUND High-grade gliomas (HGGs) are among the most aggressive CNS tumors in pediatric, adolescent, and young adult (AYA) populations, marked by rapid progression and poor survival. These tumors show considerable histopathological and …
View article: When The Brain Bleeds, And The Blood Betrays: Coagulopathy In Neurotrauma
When The Brain Bleeds, And The Blood Betrays: Coagulopathy In Neurotrauma Open
View article: Patatin-Like Phospholipase Domain-Containing Protein 8 Mutation Associated with Gonadal Dysgenesis, Cerebellar Ataxia, and Peripheral Neuropathy in an Indian Family
Patatin-Like Phospholipase Domain-Containing Protein 8 Mutation Associated with Gonadal Dysgenesis, Cerebellar Ataxia, and Peripheral Neuropathy in an Indian Family Open
View article: Adult Onset Suprasellar Xanthogranuloma: A Rare Catch!
Adult Onset Suprasellar Xanthogranuloma: A Rare Catch! Open
View article: P-626 Mitochondrial Fatty Acid Shuttle: Novel Targets in the Pathogenesis of Premature Ovarian Insufficiency
P-626 Mitochondrial Fatty Acid Shuttle: Novel Targets in the Pathogenesis of Premature Ovarian Insufficiency Open
Study question Do mitochondrial variants play a role in the pathogenesis of Premature Ovarian Insufficiency (POI)? Summary answer Genetic variants in mitochondrial and fatty acid oxidation pathways are key contributors to the pathogenesis …
View article: Primary synovial sarcoma of thyroid: Diagnostic pitfalls and importance of immunohistochemistry
Primary synovial sarcoma of thyroid: Diagnostic pitfalls and importance of immunohistochemistry Open
Synovial sarcoma in the head and neck region is relatively uncommon, and primary synovial sarcoma of the thyroid gland is extremely rare with only 19 reported cases in the English literature. The rarity of disease leads to delayed and freq…
View article: Depression and Anxiety in Couples Undergoing Infertility Treatment with Assisted Reproductive Techniques in Indian Context
Depression and Anxiety in Couples Undergoing Infertility Treatment with Assisted Reproductive Techniques in Indian Context Open
A BSTRACT Background: Psychological distress has been linked to infertility and its treatment. However, the existing literature data are scarce concerning this issue in Indian couples. Aim: To assess depression and anxiety in couples under…
View article: Dysregulation of miR‑24‑3p and miR‑186‑5p and GABA<sub>A</sub> receptor expression in focal cortical dysplasia
Dysregulation of miR‑24‑3p and miR‑186‑5p and GABA<sub>A</sub> receptor expression in focal cortical dysplasia Open
Spontaneous synaptic activity mediated by GABAA receptor is associated with epileptogenicity in focal cortical dysplasia (FCD). miRNAs are potentially involved in the regulation of GABAA receptor subunit expression and activity. This study…
View article: The Role of Inflammatory Cascade and Reactive Astrogliosis in Glial Scar Formation Post-spinal Cord Injury
The Role of Inflammatory Cascade and Reactive Astrogliosis in Glial Scar Formation Post-spinal Cord Injury Open
Reactive astrogliosis and inflammation are pathologic hallmarks of spinal cord injury. After injury, dysfunction of glial cells (astrocytes) results in glial scar formation, which limits neuronal regeneration. The blood-spinal cord barrier…
View article: Elucidating the Prognostic Role of BRAF V600E and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India
Elucidating the Prognostic Role of BRAF V600E and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India Open
Introduction: Papillary thyroid carcinoma (PTC) has an excellent prognosis, but few cases are treatment-resistant. To check the applicability of combined BRAF V600E and MEK-targeted therapy, the current study correlated BRAF V600E with the…
View article: Osteochondroma of the Tentorium Cerebelli: Report of the First Case and Review of Literature
Osteochondroma of the Tentorium Cerebelli: Report of the First Case and Review of Literature Open
Osteochondromas are tumors composed of both bony and cartilaginous elements. These slow-growing lesions commonly occur in the appendicular skeleton. Intracranial presentation is extremely rare with very isolated case reports in the literat…
View article: The BCOR-rearranged sarcoma involving the lung: Diagnosis with clinical outcome and literature review
The BCOR-rearranged sarcoma involving the lung: Diagnosis with clinical outcome and literature review Open
BCOR- rearranged sarcomas (BRS) constitute relatively newly described sarcomas, which, within the musculoskeletal sites, usually occur in the bones, followed by soft tissues. Primary BRS involving the visceral organs is very rare, and only…
View article: Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles
Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles Open
View article: The role of susceptibility-weighted imaging & contrast-enhanced MRI in the diagnosis of primary CNS vasculitis: a large case series
The role of susceptibility-weighted imaging & contrast-enhanced MRI in the diagnosis of primary CNS vasculitis: a large case series Open
Primary CNS Vasculitis (PCNSV) is a rare, diverse, and polymorphic CNS blood vessel inflammatory condition. Due to its rarity, clinical variability, heterogeneous imaging results, and lack of definitive laboratory markers, PCNSV diagnosis …
View article: Malignancy arising in adamantinomatous craniopharyngioma: Report of a rare case with unusual morphologic features
Malignancy arising in adamantinomatous craniopharyngioma: Report of a rare case with unusual morphologic features Open
Adamantinomatous craniopharyngioma is a grade 1 tumor that arises in a sellar/suprasellar location. Despite being a grade 1 tumor, there is high recurrence and endocrinal insufficiency. Malignancy arising in craniopharyngioma is extremely …
View article: Novel<i>EGFR</i>mutations in diffuse midline gliomas using cost-effective strategies: A report of 2 cases
Novel<i>EGFR</i>mutations in diffuse midline gliomas using cost-effective strategies: A report of 2 cases Open
Background Diffuse midline gliomas (DMGs) are malignant tumors predominantly affecting children, often leading to poor outcomes. The 2021 World Health Organization classification identifies 3 subtypes of DMGs, all characterized by the loss…
View article: Congenital Myasthenia Syndrome Due to a Novel DPAGT1 Gene Mutation – An Error of Glycosylation Masquerading as a Congenital Myopathy
Congenital Myasthenia Syndrome Due to a Novel DPAGT1 Gene Mutation – An Error of Glycosylation Masquerading as a Congenital Myopathy Open
View article: Comparative Analysis of Hemispherotomy in Adults versus Children- A Prospective Observational Series
Comparative Analysis of Hemispherotomy in Adults versus Children- A Prospective Observational Series Open
Background: Hemispherotomy (HS) is an effective treatment for unilateral hemispheric onset epilepsy. There are few publications for HS in adults, and there is no series comparing adults and pediatric patients of HS. Objective: To compare t…
View article: Metastatic alveolar soft part sarcoma of the kidney in a young female
Metastatic alveolar soft part sarcoma of the kidney in a young female Open
A 19-year-old female presented with left flank discomfort and swelling. Imaging revealed a large mass arising from the left kidney, and radical nephrectomy confirmed the diagnosis of alveolar soft part sarcoma (ASPS) based on histopatholog…
View article: SURG-24. FACTORS PREDICTING REMISSION AND RECURRENCE AFTER SURGICAL TREATMENT OF ACTH SECRETING PITUITARY ADENOMAS - CUSHING’S DISEASE
SURG-24. FACTORS PREDICTING REMISSION AND RECURRENCE AFTER SURGICAL TREATMENT OF ACTH SECRETING PITUITARY ADENOMAS - CUSHING’S DISEASE Open
Despite recent advances in management, disease persistence and recurrences are common in patients with ACTH secreting pituitary adenomas-Cushing’s disease (CD). The study aims to determine clinical, biochemical, radiological, histological …
View article: PATH-50. GENETIC AND EPIGENETIC PROFILING OF MENINGIOMAS TO GAIN INSIGHTS INTO MOLECULAR HETEROGENEITY AND RISK STRATIFICATION.
PATH-50. GENETIC AND EPIGENETIC PROFILING OF MENINGIOMAS TO GAIN INSIGHTS INTO MOLECULAR HETEROGENEITY AND RISK STRATIFICATION. Open
BACKGROUND Meningiomas are slow-growing CNS tumors, with most being benign (WHO grade 1) and having indolent behavior. Limited data on molecular profiling of meningiomas and its clinical implications have hindered the implementation of eff…
View article: A Rare Case of Primary Intracranial Ewing's Sarcoma
A Rare Case of Primary Intracranial Ewing's Sarcoma Open
Sir, Extraosseous Ewing's sarcoma (EES), a rare tumor, comes under the ambit of the peripheral primitive neuroectodermal tumor/Ewing's sarcoma (pPNET/ES) family of round cell neuroectodermal origin tumors with a predilection for soft tissu…
View article: Macrofollicular Architecture in Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Pitfall in Thyroid Practice
Macrofollicular Architecture in Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Pitfall in Thyroid Practice Open
View article: 136 Illustrating Quality Improvement in Extended Focused Assessment With Sonography in Trauma Through a Tailored Educational Intervention
136 Illustrating Quality Improvement in Extended Focused Assessment With Sonography in Trauma Through a Tailored Educational Intervention Open
View article: Current status of DNA methylation profiling in neuro-oncology as a diagnostic support tool: A review
Current status of DNA methylation profiling in neuro-oncology as a diagnostic support tool: A review Open
Over the last 2 decades, high throughput genome-wide molecular profiling has revealed characteristic genetic and epigenetic alterations associated with different types of central nervous system (CNS) tumors. DNA methylation profiling has e…
View article: Helicobacter-induced pyoderma gangrenosum–like skin ulcers in a case of Bruton’s agammaglobulinemia
Helicobacter-induced pyoderma gangrenosum–like skin ulcers in a case of Bruton’s agammaglobulinemia Open
View article: Management protocol and surgical techniques for MRI–Negative Cushing’s disease: a series of 6 cases
Management protocol and surgical techniques for MRI–Negative Cushing’s disease: a series of 6 cases Open
Up to 40% of Cushing’s disease (CD) patients show no evidence of an adenoma on dynamic contrast-enhanced MRI. Inferior petrosal sinus sampling (IPSS) remains the gold standard for diagnosis in these patients. Remission rates in MRI–Negativ…