Mehdi Gholam‐Rezaee
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View article: Therapeutic Drug Monitoring of Olanzapine: Effects of Clinical Factors on Plasma Concentrations in Psychiatric Patients
Therapeutic Drug Monitoring of Olanzapine: Effects of Clinical Factors on Plasma Concentrations in Psychiatric Patients Open
Background: Therapeutic drug monitoring (TDM) is strongly recommended for olanzapine due to its high pharmacokinetic variability. This study aimed to investigate the impact of various clinical factors on olanzapine plasma concentrations in…
View article: Risk factors for mood disorders among offspring of parents with bipolar disorder: Findings from a discordant-sibling study
Risk factors for mood disorders among offspring of parents with bipolar disorder: Findings from a discordant-sibling study Open
The purpose of this naturalistic, prospective study was to identify risk factors for mood disorders in offspring of parents with bipolar disorder (BPD) using the discordant-sibling design by comparing premorbid psychopathology or symptoms,…
View article: Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population
Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population Open
View article: Childhood maltreatment and late-life generalized anxiety disorder: Are personality and attachment characteristics mediators?
Childhood maltreatment and late-life generalized anxiety disorder: Are personality and attachment characteristics mediators? Open
Background: Childhood maltreatment and generalized anxiety disorder (GAD) are related in adulthood. This association is not clear in the elderly. This work aims to investigate the role of adult attachment style and personality traits in th…
View article: Psychotic features, particularly mood incongruence, as a hallmark of severity of bipolar I disorder
Psychotic features, particularly mood incongruence, as a hallmark of severity of bipolar I disorder Open
View article: Calling situated: a survey among medical students supplemented by a qualitative study and a comparison with a surveyed sample of physicians
Calling situated: a survey among medical students supplemented by a qualitative study and a comparison with a surveyed sample of physicians Open
View article: CYP2C19 expression modulates affective functioning and hippocampal subiculum volume—a large single-center community-dwelling cohort study
CYP2C19 expression modulates affective functioning and hippocampal subiculum volume—a large single-center community-dwelling cohort study Open
View article: Environmental factors in offspring of parents with mood disorders and their role in parent–child transmission: findings from a 14-year prospective high-risk study
Environmental factors in offspring of parents with mood disorders and their role in parent–child transmission: findings from a 14-year prospective high-risk study Open
View article: Evolution of impulsivity levels in relation to early cannabis use in violent patients in the early phase of psychosis
Evolution of impulsivity levels in relation to early cannabis use in violent patients in the early phase of psychosis Open
Background Prevention of violent behaviors (VB) in the early phase of psychosis (EPP) is a real challenge. Impulsivity was shown to be strongly related to VB, and different evolutions of impulsivity were noticed along treatments. One possi…
View article: Plant Sterols, Cholesterol Metabolism, and Cognitive Decline in the Older People: A Population-Based Study
Plant Sterols, Cholesterol Metabolism, and Cognitive Decline in the Older People: A Population-Based Study Open
View article: Study protocol for the ETMED-L project: longitudinal study of mental health and interpersonal competence of medical students in a Swiss university using a comprehensive framework of empathy
Study protocol for the ETMED-L project: longitudinal study of mental health and interpersonal competence of medical students in a Swiss university using a comprehensive framework of empathy Open
Introduction Physician interpersonal competence is crucial for patient care. How interpersonal competence develops during undergraduate medical education is thus a key issue. Literature on the topic consists predominantly of studies on emp…
View article: Correction: Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort
Correction: Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort Open
View article: Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution Open
Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, all…
View article: Ecological momentary assessment of emotional processing: An exploratory analysis comparing daily life and a psychotherapy analogue session
Ecological momentary assessment of emotional processing: An exploratory analysis comparing daily life and a psychotherapy analogue session Open
Background Emotional processing has been studied in psychotherapy as a state‐dependent, sequential process of change. So far, no studies have applied this conceptualisation of emotional processing to the assessments of emotion in daily lif…
View article: Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort
Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort Open
View article: Does Cognitive Functioning Predict Chronic Pain in Older Adult? Results From the CoLaus|PsyCoLaus Longitudinal Study
Does Cognitive Functioning Predict Chronic Pain in Older Adult? Results From the CoLaus|PsyCoLaus Longitudinal Study Open
View article: Factors associated with subjective cognitive decline in dementia‐free older adults—A population‐based study
Factors associated with subjective cognitive decline in dementia‐free older adults—A population‐based study Open
Background Subjective cognitive decline (SCD) is common in older adults, affects quality of life (QoL), and may represent the earliest clinical manifestation of cognitive decline evolving to dementia. Still little is known about factors as…
View article: Retrospectively assessed trajectories of PTSD symptoms and their subsequent comorbidities
Retrospectively assessed trajectories of PTSD symptoms and their subsequent comorbidities Open
Mental health outcomes after trauma exposure were considerably more complex than the four previously established adjustment trajectories. Here, we uncovered additional and more heterogeneous adjustment patterns comprised of PTSS trajectori…
View article: Backtracing persistent biomarker shifts to the age of onset: A novel procedure applied to men’s and women’s white blood cell counts in post-traumatic stress disorder
Backtracing persistent biomarker shifts to the age of onset: A novel procedure applied to men’s and women’s white blood cell counts in post-traumatic stress disorder Open
Background: Traumatic experiences tend to be preserved in altered biomarker profiles. These profiles can be traced back from cross-sectional data regarding the age of exposure. Consequently, the change across developmental stages, e.g. fro…
View article: Predicting involuntary hospitalization in psychiatry: A machine learning investigation
Predicting involuntary hospitalization in psychiatry: A machine learning investigation Open
Background Coercion in psychiatry is a controversial issue. Identifying its predictors and their interaction using traditional statistical methods is difficult, given the large number of variables involved. The purpose of this study was to…
View article: Factors associated with repetitive violent behavior of psychiatric inpatients
Factors associated with repetitive violent behavior of psychiatric inpatients Open
View article: Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication
Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication Open
Background It has been suggested that exposure to Childhood Trauma [CT] may play a role in the risk of obesity in Early Psychosis [EP] patients; however, whether this is independently of age at exposure to CT and the medication profile has…
View article: Subtypes of narcissistic personality disorder based on psychotherapy process: A longitudinal nonparametric analysis.
Subtypes of narcissistic personality disorder based on psychotherapy process: A longitudinal nonparametric analysis. Open
The present study aims at empirically exploring subtypes of narcissistic personality disorder (NPD), based on patient descriptors of the psychotherapeutic process. Subtype identification and characterization of NPD is central, in particula…
View article: Topology predicts long-term functional outcome in early psychosis
Topology predicts long-term functional outcome in early psychosis Open
View article: Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community
Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community Open
View article: Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients
Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients Open
View article: Associations of Personality Traits With Chronic Low-Grade Inflammation in a Swiss Community Sample
Associations of Personality Traits With Chronic Low-Grade Inflammation in a Swiss Community Sample Open
Objective: Among the major dimensions of personality, high Neuroticism and low Conscientiousness have frequently been linked to worse health-related behaviors and poor health outcomes. However, studies on the association between per…
View article: Major depression subtypes are differentially associated with migraine subtype, prevalence and severity
Major depression subtypes are differentially associated with migraine subtype, prevalence and severity Open
Objective Migraine and major depressive disorder show a high rate of comorbidity, but little is known about the associations between the subtypes of major depressive disorder and migraine. In this cross-sectional study we aimed at investig…
View article: Primary care outpatient treatment centre for Intellectual Disabilities helps prevent inpatient psychiatry treatments
Primary care outpatient treatment centre for Intellectual Disabilities helps prevent inpatient psychiatry treatments Open
Background: Our qualitative study evaluated the following two questions: For what needs do adults with intellectual disabilities consult a primary care outpatient treatment at a psychiatry department? How have hospitalization rates and exp…
View article: A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants
A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants Open
The severity of symptoms as well as efficacy of antidepressants in major depressive disorder (MDD) is modified by single nucleotide polymorphisms (SNPs) in different genes, which may contribute in an additive or synergistic fashion. We aim…