Explanipedia

An alternate receptor for adeno-associated viruses Open

Bijay Dhungel, Hua Xu, Rajini Nagarajah, Joseph N. Vitale, Alex C. H. Wong , et al. · 2025

Systemic gene therapy using adeno-associated virus (AAV) vectors is approved for the treatment of several genetic disorders, but challenges and toxicities associated with high vector doses remain. We report an alternate receptor for AAV (A…

Intrinsically Disordered Regions Define Unique Protein Interaction Networks in <span>CHD</span> Family Remodelers Open

Mehdi Sharifi Tabar, Chirag Parsania, Caroline Giardina, Yue Feng, Alex C. H. Wong , et al. · 2025

Chromodomain helicase DNA‐binding (CHD) enzymes play a pivotal role in genome regulation. They possess highly conserved ATPase domains flanked by poorly characterized and intrinsically disordered N‐ and C‐termini. Using mass spectrometry, …

Intrinsically Disordered Regions Define Unique Protein Interaction Networks in CHD Family Remodelers Open

Mehdi Sharifi Tabar, Chirag Parsania, Caroline Giardina, Yue Feng, Alex C. H. Wong , et al. · 2024

Chromodomain helicase DNA-binding (CHD1-9) enzymes reposition nucleosomal DNA for transcription, recombination, and replication. They possess highly conserved ATPase domains flanked by poorly characterised N- and C-termini, which are enric…

Illuminating the dark protein-protein interactome Open

Mehdi Sharifi Tabar, Chirag Parsania, Hong Chen, Xiaodong Su, Charles G. Bailey , et al. · 2022

Mapping oncogenic protein interactions for precision medicine Open

Mehdi Sharifi Tabar, Habib Francis, Dannel Yeo, Charles G. Bailey, John E.J. Rasko · 2022

Normal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in on…

The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells Open

Bijay Dhungel, Geoffray Monteuuis, Caroline Giardina, Mehdi Sharifi Tabar, Yue Feng , et al. · 2021

Chimeric RNAs are often associated with chromosomal rearrangements in cancer. In addition, they are also widely detected in normal tissues, contributing to transcriptomic complexity. Despite their prevalence, little is known about the char…

Structure–function relationships explain CTCF zinc finger mutation phenotypes in cancer Open

Charles G. Bailey, Shailendra Gupta, Cynthia Metierre, Punkaja M. S. Amarasekera, Patrick O’Young , et al. · 2021

CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutat…

Unique protein interaction networks define the chromatin remodelling module of the NuRD complex Open

Mehdi Sharifi Tabar, Caroline Giardina, Yue Feng, Habib Francis, Hakimeh Moghaddas Sani , et al. · 2021

The combination of four proteins and their paralogues including MBD2/3, GATAD2A/B, CDK2AP1 and CHD3/4/5, which we refer to as the MGCC module, form the chromatin remodelling module of the nucleosome remodelling and deacetylase (NuRD) compl…

Author response for "Unique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex" Open

Mehdi Sharifi Tabar, Caroline Giardina, Yue Feng, Habib Francis, Hakimeh Moghaddas Sani , et al. · 2021

Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy Open

Zaniar Ghazizadeh, Faranak Fattahi, Mehdi Mirzaei, Delger Bayersaikhan, Jaesuk Lee , et al. · 2021

(Stem Cell Reports 10, 848–859; March 13, 2018) The authors wish to make the following corrections to Figures 5C and S4G of this article. The authors declare that these mistakes do not affect the results and conclusions of the study. In Fi…

Unique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex Open

Mehdi Sharifi Tabar, Caroline Giardina, Yue Feng, Habib Francis, Hakimeh Moghaddas Sani , et al. · 2021

The combination of four proteins and their paralogues including MBD2/3, GATAD2A/B, CDK2AP1, and CHD3/4/5, which we refer to as the MGCC module, form the chromatin remodeling module of the Nucleosome Remodeling and Deacetylase (NuRD) comple…

The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture Open

Jason K. K. Low, Ana P. G. Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb , et al. · 2020

The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture Open

Jason K. K. Low, Ana PG Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb , et al. · 2020

The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to biochemical analysis. We present the first integrated analysis of the architecture of the native mammalian …

Understanding the Architecture, Assembly, and Interactome of the Nucleosome Remodelling and Deacetylase (NuRD) Complex Open

Mehdi Sharifi Tabar · 2019

This thesis presents data to enhance our understanding of the composition, assembly, and structure of the nucleosome remodeling and deacetylase (NuRD) complex, a transcriptional coregulator that is strongly linked to cancer. Understanding …

The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex are conserved across multiple cell lines Open

Mehdi Sharifi Tabar, Joel P. Mackay, Jason K. K. Low · 2019

The nucleosome remodelling and deacetylase complex (NuRD) is a widely conserved regulator of gene expression. The determination of the subunit composition of the complex and identification of its binding partners are important steps toward…

Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models Open

Ali Fathi, Mehdi Mirzaei, Banafsheh Dolatyar, Mehdi Sharifi Tabar, Mahnaz Bayat , et al. · 2018

Despite the progress in safety and efficacy of cell replacement therapy with pluripotent stem cells (PSCs), the presence of residual undifferentiated stem cells or proliferating neural progenitor cells with rostral identity remains a major…

Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy Open

Zaniar Ghazizadeh, Faranak Fattahi, Mehdi Mirzaei, Delger Bayersaikhan, Jaesuk Lee , et al. · 2018

Refinement of the subunit interaction network within the nucleosome remodelling and deacetylase (Nu<span>RD</span>) complex Open

Mario Torrado, Jason K. K. Low, Ana P. G. Silva, Jason W. Schmidberger, Maryam Sana , et al. · 2017

The nucleosome remodelling and deacetylase (Nu RD ) complex is essential for the development of complex animals. Nu RD has roles in regulating gene expression and repairing damaged DNA . The complex comprises at least six proteins with two…

Bovine Sex Determining Region Y: Cloning, Optimized Expression, and Purification Open

Bijan Soleymani, Sayed Hassan Hafezian, Ghodratollah Rahimi Mianji, Kamran Mansouri, B. Chaharaein , et al. · 2016

Sex determining region Y gene (SRY) is located on Y chromosome and encodes a protein with 229 amino acids. In this study, ORF region of SRY with a length of 690 bp was synthesized using PCR and ligated to pET28a (+), then transformed in E.…

The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7 Open

Jason W. Schmidberger, Mehdi Sharifi Tabar, Mario Torrado, Ana P. G. Silva, Michael J. Landsberg , et al. · 2016

The nucleosome remodeling and deacetylase (NuRD) complex remodels the genome in the context of both gene transcription and DNA damage repair. It is essential for normal development and is distributed across multiple tissues in organisms ra…

Evaluating Electroporation and Lipofectamine Approaches for Transient and Stable Transgene Expressions in Human Fibroblasts and Embryonic Stem Cells. Open

Mehdi Sharifi Tabar, Mahdi Hesaraki, Fereshteh Esfandiari, Fazel Sahraneshin Samani, Haghighat Vakilian , et al. · 2015

Electroporation was an efficient tool for genetic engineering of hESCs compared to the chemical method. The genetic background of the subjected cell line for transfection seemed to be a fundamental factor in each gene delivery method. For …

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