Mohammad Najafi
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View article: Transcriptomic signatures in Gaucher disease subtypes: A systems biology perspective
Transcriptomic signatures in Gaucher disease subtypes: A systems biology perspective Open
View article: Mitigating atherosclerosis: Integrating vaccines with gene targets
Mitigating atherosclerosis: Integrating vaccines with gene targets Open
View article: Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach
Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach Open
View article: Heparin suppresses FoxO1/pFoxO1 signaling axis in vascular smooth muscle cells
Heparin suppresses FoxO1/pFoxO1 signaling axis in vascular smooth muscle cells Open
View article: Exploring the potential of predicted miRNAs on the genes involved in the expansion of hematopoietic stem cells
Exploring the potential of predicted miRNAs on the genes involved in the expansion of hematopoietic stem cells Open
View article: Step by step analysis on gene datasets of growth phases in hematopoietic stem cells
Step by step analysis on gene datasets of growth phases in hematopoietic stem cells Open
The data revealed that the different signaling pathways are activated in each of the G0, G1, and differentiation stages so that their genes may be targeted to improve the HSC therapy.
View article: NF-kB affects migration of vascular smooth muscle cells after treatment with heparin and ibrutinib
NF-kB affects migration of vascular smooth muscle cells after treatment with heparin and ibrutinib Open
The migration of vascular smooth muscle cells (VSMCs) is one of the most important events in the remodeling of atherosclerosis plaque. The aim of study was to investigate the role of Heparin in the VSMC migration and its association with t…
View article: Differential gene expression patterns in ST-elevation Myocardial Infarction and Non-ST-elevation Myocardial Infarction
Differential gene expression patterns in ST-elevation Myocardial Infarction and Non-ST-elevation Myocardial Infarction Open
The ST-elevation Myocardial Infarction (STEMI) and Non-ST-elevation Myocardial Infarction (NSTEMI) might occur because of coronary artery stenosis. The gene biomarkers apply to the clinical diagnosis and therapeutic decisions in Myocardial…
View article: Systems biology approach to identify biomarkers and therapeutic targets for colorectal cancer
Systems biology approach to identify biomarkers and therapeutic targets for colorectal cancer Open
View article: Differentially expressed genes of RNA-seq data are suggested on the intersections of normalization techniques
Differentially expressed genes of RNA-seq data are suggested on the intersections of normalization techniques Open
View article: Beta arrestin‐related signalling axes are influenced by dexamethasone and metformin in vascular smooth muscle cells cultured in high glucose condition
Beta arrestin‐related signalling axes are influenced by dexamethasone and metformin in vascular smooth muscle cells cultured in high glucose condition Open
Background Metformin (Met) and dexamethasone (Dexa) are known to reduce blood sugar levels and anti‐inflammatory effects, respectively. Based on the acceleration of atherosclerosis process in diabetes, the β‐arrestin 2 (BARR2) gene and pro…
View article: Cellular crosstalk in atherosclerotic plaque microenvironment
Cellular crosstalk in atherosclerotic plaque microenvironment Open
Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and r…
View article: Cross talk between bacterial and human gene networks enriched using ncRNAs in IBD disease
Cross talk between bacterial and human gene networks enriched using ncRNAs in IBD disease Open
View article: Carvacrol Exerts Anti-Inflammatory, Anti-Oxidative Stress and Hepatoprotective Effects against Diclofenac-Induced Liver Injury in Male Rats
Carvacrol Exerts Anti-Inflammatory, Anti-Oxidative Stress and Hepatoprotective Effects against Diclofenac-Induced Liver Injury in Male Rats Open
Background: Diclofenac (DIC) is an NSAID that can cause toxic effects in animals and humans and carvacrol (CAR) is a monoterpene compound that displays effective pharmacological and biological actions. The purpose of this work was to asses…
View article: Effect of portulaca oleracea (purslane) extract on inflammatory factors in nonalcoholic fatty liver disease: A randomized, double-blind clinical trial
Effect of portulaca oleracea (purslane) extract on inflammatory factors in nonalcoholic fatty liver disease: A randomized, double-blind clinical trial Open
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most serious liver disease that influences nearly-one-quarter of the worldwide adult population. Although the main mechanism of NAFLD is complex, several events can cause …
View article: Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions
Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions Open
View article: The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer
The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer Open
View article: Focal adhesion kinase–related pathways may be suppressed by metformin in vascular smooth muscle cells in high glucose conditions
Focal adhesion kinase–related pathways may be suppressed by metformin in vascular smooth muscle cells in high glucose conditions Open
Introduction Cardiovascular diseases are known as one of the important causes of death in patients with diabetes mellitus. Metformin is used as an oral medication for reducing blood sugar. In this study, the effects of metformin were inves…
View article: The Effect of Hydroalcoholic Seed Extract of Securigera Securidaca on the Hepatic Renin-Angiotensin System in the Streptozotocin-Induced Diabetic Animal Model
The Effect of Hydroalcoholic Seed Extract of Securigera Securidaca on the Hepatic Renin-Angiotensin System in the Streptozotocin-Induced Diabetic Animal Model Open
BACKGROUND: The aim of the study was to investigate the effect of hydroalcoholic seed extract of Securigera securidaca (S. securidaca) (HESS) on liver local reninangiotensin system (RAS) in streptozotocin-induced diabetic rats. METHODS: Th…
View article: Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress
Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress Open
Diclofenac (DIC) is administrated to treat pain, inflammatory disorders, and dysmenorrhea but kidney problems are the main worries of the agent. The literature has revealed that quercetin (QR) has anti-inflammatory and antioxidant attribut…
View article: miR-27a inhibits molecular adhesion between monocytes and human umbilical vein endothelial cells; systemic approach
miR-27a inhibits molecular adhesion between monocytes and human umbilical vein endothelial cells; systemic approach Open
Objective The endothelial cells overexpress the adhesion molecules in the leukocyte diapedesis pathway, developing vessel subendothelial molecular events. In this study, miR-194 and miR-27a were predicted and investigated on the expression…
View article: Additional file 3 of Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions
Additional file 3 of Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions Open
Additional file 3.
View article: Predicted miRNAs suppressed cell proliferation and migration via FAK/VASP axis; Systems biology approach
Predicted miRNAs suppressed cell proliferation and migration via FAK/VASP axis; Systems biology approach Open
Introduction: Many studies have reported that some genes in cellular proliferation and migration pathways relate to CRC pathogenesis. The aim of this study was to predict bioinformatically important gene-related miRNAs and investigate expe…
View article: The compliance of surgical prophylactic antibiotics with standard protocols in Imam Reza teaching hospital of Birjand, Iran
The compliance of surgical prophylactic antibiotics with standard protocols in Imam Reza teaching hospital of Birjand, Iran Open
Background and Objectives: Taking unnecessary or inappropriate prophylactic antibiotics can cause infections with re- sistant organisms. The present study aimed to investigate administration prophylactic antibiotics in surgery ward and its…
View article: The compliance of surgical prophylactic antibiotics with standard protocols in Imam Reza teaching hospital of Birjand, Iran
The compliance of surgical prophylactic antibiotics with standard protocols in Imam Reza teaching hospital of Birjand, Iran Open
Background and Objectives: Taking unnecessary or inappropriate prophylactic antibiotics can cause infections with resistant organisms. The present study aimed to investigate administration prophylactic antibiotics in surgery ward and its c…
View article: Human umbilical cord mesenchymal stem cells express cholinergic neuron markers during co-culture with amniotic membrane cells and retinoic acid induction
Human umbilical cord mesenchymal stem cells express cholinergic neuron markers during co-culture with amniotic membrane cells and retinoic acid induction Open
Background: A wide variety of cytokines are released from human amniotic membrane cells (hAMCs), which can increase the rate of differentiation of mesenchymal stem cells into the neurons. We studied the effect of Retinoic Acid (RA) …
View article: The Role of MicroRNA 143 and MicroRNA 206 in The Regulation of Apoptosis in Mouse Lukemia Cancer Cells and Spermatogonial Cells.
The Role of MicroRNA 143 and MicroRNA 206 in The Regulation of Apoptosis in Mouse Lukemia Cancer Cells and Spermatogonial Cells. Open
Using intelligent transfection by NPs, we were able to induce apoptosis on EL4 cells and maintain acceptable SSC survival rates.
View article: Evaluation of the Toxicity Effects of Polyethyleneimine (Pei) on Cell Viability and Morphology of VSMC Cells
Evaluation of the Toxicity Effects of Polyethyleneimine (Pei) on Cell Viability and Morphology of VSMC Cells Open
Background and Objectives: Today, PEI is used for high-efficiency gene transfection. This polycation can have toxic effects on cells due to charged amine groups. This study evaluated the toxic effects of PEI in both single and oligonucleot…
View article: Palmitic acid increases HCK gene and protein expression levels in vascular smooth muscle cells
Palmitic acid increases HCK gene and protein expression levels in vascular smooth muscle cells Open
Background and Aims: Saturated fatty acids are known to involve in atherosclerosis through different biologic pathways. The aim of this study was to investigate the effects of palmitic acid (PA) on the tyrosine-protein kinase (HCK) gene an…
View article: Adhesion of monocytes and endothelial cells isolated from the human aorta suppresses by miRNA-PEI particles
Adhesion of monocytes and endothelial cells isolated from the human aorta suppresses by miRNA-PEI particles Open