Ming Tan
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View article: B cell maturation antigen is a novel target for immunotherapy of acute myeloid leukemia
B cell maturation antigen is a novel target for immunotherapy of acute myeloid leukemia Open
B cell maturation antigen (BCMA) has emerged as a prominent immunotherapeutic target in multiple myeloma (MM) due to its restricted expression on MM cells, plasma cells and mature B cells, with minimal presence in other normal tissues. In …
View article: Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions
Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions Open
Background: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality, yet its pathophysiology is not fully understood. Recent studies suggest that dysregulated maternal immune responses, particularly involving…
View article: Efficacy and safety of different treatments in chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis
Efficacy and safety of different treatments in chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis Open
Background Chemotherapy-induced thrombocytopenia (CIT) is a challenge in cancer treatment, increasing bleeding risks and reducing chemotherapy dose. We sought to compare the efficacy and safety of various treatments for CIT. Methods Random…
View article: MedCite: Can Language Models Generate Verifiable Text for Medicine?
MedCite: Can Language Models Generate Verifiable Text for Medicine? Open
Existing LLM-based medical question-answering systems lack citation generation and evaluation capabilities, raising concerns about their adoption in practice. In this work, we introduce \name, the first end-to-end framework that facilitate…
View article: Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisome proliferator-activated receptor alpha
Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisome proliferator-activated receptor alpha Open
CBAs promoted MASLD through inducing S1PR2 translocation into the nucleus, where it bound PPARα to interdict the function of PPARα in regulating genes involved in lipid catabolism.
View article: Effects of implementation leadership of head nurses on nurses' evidence-based pain management practices behavior
Effects of implementation leadership of head nurses on nurses' evidence-based pain management practices behavior Open
Background Nurses' evidence-based practice competencies were positively correlated with the implementation leadership (IL) of head nurses. However, there was no study to analyze the effect of IL on nurses’ evidence-based pain management pr…
View article: ε-Poly-l-lysine Suppressed Decay Development and Maintained Storage Quality in Guava Fruit by ROS Level Regulation and Antioxidant Ability Enhancement
ε-Poly-l-lysine Suppressed Decay Development and Maintained Storage Quality in Guava Fruit by ROS Level Regulation and Antioxidant Ability Enhancement Open
Guava fruit is susceptible to decay, leading to losses in storability and quality. ε-Poly-l-lysine (ε-PL) is a safe antimicrobial polypeptide that has proven to be effective in preserving produce’s quality. In the present research, ε-PL, a…
View article: Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy
Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy Open
Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring‐opening polymerization of special lactams. However, developing a green polyme…
View article: Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy
Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy Open
Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring‐opening polymerization of special lactams. However, developing a green polyme…
View article: Comparison of the clinicopathological characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis with/without infection at diagnosis
Comparison of the clinicopathological characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis with/without infection at diagnosis Open
Infection at initial diagnosis does not affect the outcomes of children with AGN, although it could lead to a reduction in kidney function.
View article: Metabolic and Immune Adaptations in Preterm Neonates at Early Postnatal Period: Integrated Analysis of Key Metabolites and Pathways
Metabolic and Immune Adaptations in Preterm Neonates at Early Postnatal Period: Integrated Analysis of Key Metabolites and Pathways Open
Objective This study was aimed at clarifying the unique metabolic alterations in preterm neonates, distinct from full‐term neonates, between the first 24 and 48 h postnatally. Methods A cohort of 60 preterm and 60 full‐term neonates was an…
View article: Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus
Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus Open
Introduction Depression is a prevalent and significant psychological consequence of traumatic brain injury (TBI). Ferroptosis, an iron‐dependent form of regulated cell death, exacerbates the neurological damage associated with TBI. This st…
View article: The Generating Logic, Overall Characteristics and Realistic Value of Chinese Cultural Thought in the New Era
The Generating Logic, Overall Characteristics and Realistic Value of Chinese Cultural Thought in the New Era Open
With socialism with Chinese characteristics entering a new historical stage, cultural construction is increasingly important to the stability and development of the country. As the general program and guiding ideology of the cultural const…
View article: Artificial Intelligence-Large Language Models (AI-LLMs) for Reliable and Accurate Cardiotocography (CTG) Interpretation in Obstetric Practice
Artificial Intelligence-Large Language Models (AI-LLMs) for Reliable and Accurate Cardiotocography (CTG) Interpretation in Obstetric Practice Open
BACKGROUND Accurate interpretation of Cardiotocography (CTG) is a critical tool for monitoring fetal well-being during pregnancy and labor, providing crucial insights into fetal heart rate and uterine contractions. Advanced artificial inte…
View article: The regulatory effects of mitragynine on P-glycoprotein transporter
The regulatory effects of mitragynine on P-glycoprotein transporter Open
Objectives Kratom preparation containing Mitragyna speciosa Korth plant is frequently used as a recreational drug. Mitragynine, a major alkaloid isolated from M. speciosa, is often detected concurrently with other drugs during forensic ana…
View article: Assess the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: performance evaluation study (Preprint)
Assess the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: performance evaluation study (Preprint) Open
BACKGROUND Interpreting histopathology slides and scientific figures requires specialized skills and knowledge. Pathologists analyze various tissues and cells, while the general population often struggles with the technical information in…
View article: Construction and verification of an innovative immune-related and hallmark gene sets prognostic model for bladder cancer
Construction and verification of an innovative immune-related and hallmark gene sets prognostic model for bladder cancer Open
We constructed and validated a novel prognostic model for risk stratification in BC based on immunologic and hallmark genes sets, which presents a novel perspective on rational treatment approaches and accurate prognostic evaluations for B…
View article: Construction and analysis of a lysosome-dependent cell death score-based prediction model for non-small cell lung cancer
Construction and analysis of a lysosome-dependent cell death score-based prediction model for non-small cell lung cancer Open
The study showed a significant increase in the proportion of monocytes in NSCLC tissues, suggesting their important role in cancer progression. Cell communication analysis indicated that macrophages, smooth muscle cells, and myeloid cells …
View article: The promise and challenges of Artificial Intelligence-Large Language Models (AI-LLMs) in obstetric and gynecology
The promise and challenges of Artificial Intelligence-Large Language Models (AI-LLMs) in obstetric and gynecology Open
HIGHLIGHTS 1. The article highlights how Artificial Intelligence with Large Language Models (AI-LLMs) greatly improves diagnosis and treatment personalization in obstetrics & gynecology, and also enhances medical education through interact…
View article: Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence
Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence Open
Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with…