Mei–Hsuan Lee
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View article: Clinical Outcomes of Different Generation <scp>EGFR TKIs</scp> in Susceptible <scp>EGFR</scp>‐Mutated Advanced Nonsmall‐Cell Lung Cancer
Clinical Outcomes of Different Generation <span>EGFR TKIs</span> in Susceptible <span>EGFR</span>‐Mutated Advanced Nonsmall‐Cell Lung Cancer Open
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are indicated for advanced lung adenocarcinoma patients harboring susceptible EGFR mutations. The aim of this retrospective study was to compare the effectiveness of…
View article: Public health strategies for hepatocellular carcinoma: from risk factors to prevention and control
Public health strategies for hepatocellular carcinoma: from risk factors to prevention and control Open
Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as one of the leading causes of cancer-related deaths worldwide. This review synthesizes current evidence on HCC epidemiology, highlighting both modifiable and no…
View article: Corrigendum: “Causal Mediation Analyses for the Natural Course of Hepatitis C: A Prospective Cohort Study” [J Epidemiol 35(1) (2025) 21–29]
Corrigendum: “Causal Mediation Analyses for the Natural Course of Hepatitis C: A Prospective Cohort Study” [J Epidemiol 35(1) (2025) 21–29] Open
View article: In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma
In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma Open
This combination therapy was safe and effective, with two out of four patients demonstrating objective responses. These preliminary findings warrant further investigation into larger clinical cohorts.
View article: Ethanol inhibits the growth and metastasis of hepatocellular carcinoma by inducing immunogenic cell death
Ethanol inhibits the growth and metastasis of hepatocellular carcinoma by inducing immunogenic cell death Open
Background Immunogenic cell death (ICD) can elicit an adaptive immune response with significant antitumor effects. Percutaneous ethanol injection therapy has been applied as tumor ablation for small hepatocellular carcinoma (HCC). However,…
View article: High Steatosis-Associated Fibrosis Estimator scores predict hepatocellular carcinoma in viral and non-viral hepatitis and metabolic dysfunction-associated steatotic liver disease
High Steatosis-Associated Fibrosis Estimator scores predict hepatocellular carcinoma in viral and non-viral hepatitis and metabolic dysfunction-associated steatotic liver disease Open
Background/Aims: There are no hepatocellular carcinoma (HCC) surveillance recommendations for non-viral chronic liver diseases (CLD), such as metabolic dysfunction-associated steatotic liver disease (MASLD). We explored the Steatosis-Assoc…
View article: Intratumoral administration of poly‐<scp>ICLC</scp> enhances the antitumor effects of anti‐<scp>PD</scp>‐1
Intratumoral administration of poly‐<span>ICLC</span> enhances the antitumor effects of anti‐<span>PD</span>‐1 Open
Background Immune checkpoint inhibitors are effective to treat hepatocellular carcinoma (HCC) yet only successful in a small part of patients. This study aimed to investigate whether poly‐ICLC, an immune stimulant, can enhance the antitumo…
View article: An accurate genetic colocalization method for the HLA locus
An accurate genetic colocalization method for the HLA locus Open
Genetic colocalization analyses are frequently conducted to determine if causal signals at a genetic locus are shared between two phenotypes. However, colocalization is rarely undertaken at the HLA locus, due to its complex linkage disequi…
View article: Causal Mediation Analyses for the Natural Course of Hepatitis C: A Prospective Cohort Study
Causal Mediation Analyses for the Natural Course of Hepatitis C: A Prospective Cohort Study Open
Both intrahepatic and extrahepatic manifestations mediated approximately half of HCV-induced mortality. The mediation mechanisms are supported by a dose-response relationship of HCV viral load.
View article: Fibrosis-4 index stratifies risks of hepatocellular carcinoma in patients with chronic hepatitis C
Fibrosis-4 index stratifies risks of hepatocellular carcinoma in patients with chronic hepatitis C Open
The baseline FIB-4 index can stratify the risks of HCC in untreated CHC patients, even those without viremia. The FIB-4 index should thus be included in the management of CHC.
View article: Real-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Real-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan Open
Eight-week GLE/PIB therapy was effective and well tolerated in all TN patients, regardless of cirrhosis status.
View article: Long-term Risks of Cirrhosis and Hepatocellular Carcinoma Across Steatotic Liver Disease Subtypes
Long-term Risks of Cirrhosis and Hepatocellular Carcinoma Across Steatotic Liver Disease Subtypes Open
INTRODUCTION: The prospective study aimed to investigate the long-term associated risks of cirrhosis and hepatocellular carcinoma (HCC) across various subtypes of steatotic liver disease (SLD). METHODS: We enrolled 332,175 adults who parti…
View article: 5-Methoxytryptophan enhances the sensitivity of sorafenib on the inhibition of proliferation and metastasis for lung cancer cells
5-Methoxytryptophan enhances the sensitivity of sorafenib on the inhibition of proliferation and metastasis for lung cancer cells Open
View article: Risk of Hepatocellular Carcinoma After Spontaneous Clearance of Hepatitis C Virus and in Noncirrhosis Chronic Hepatitis C Patients With Sustained Virological Response: A Systematic Review
Risk of Hepatocellular Carcinoma After Spontaneous Clearance of Hepatitis C Virus and in Noncirrhosis Chronic Hepatitis C Patients With Sustained Virological Response: A Systematic Review Open
In a hepatitis C virus (HCV)–controlled human infection model (CHIM), healthy volunteers are inoculated with HCV and then treated. Residual hepatocellular carcinoma (HCC) risk after viral clearance is an important consideration when evalua…
View article: <i>IFNL4</i> Genotype Frequencies in Asian Populations Support Shorter Duration Therapy with Sofosbuvir-Based Hepatitis C Virus Regimens to Increase the Number Cured
<i>IFNL4</i> Genotype Frequencies in Asian Populations Support Shorter Duration Therapy with Sofosbuvir-Based Hepatitis C Virus Regimens to Increase the Number Cured Open
Globally, ∼56.8 million people are chronically infected with hepatitis C virus (HCV), with about half residing in Asia. The cost and efficiency of delivering regimens based on direct-acting antiviral agents for HCV are important considerat…
View article: Community-centered Disease Severity Assessment of Metabolic Dysfunction-associated Fatty Liver Disease
Community-centered Disease Severity Assessment of Metabolic Dysfunction-associated Fatty Liver Disease Open
A higher proportion of lean MAFLD patients with metabolic abnormalities had advanced fibrosis. HCV infection was significantly associated with advanced fibrosis.
View article: Neoantigen vaccination augments antitumor effects of anti-PD-1 on mouse hepatocellular carcinoma
Neoantigen vaccination augments antitumor effects of anti-PD-1 on mouse hepatocellular carcinoma Open
Immune checkpoint inhibitors are groundbreaking resources for cancer therapy. However, only a few patients with hepatocellular carcinoma (HCC) have shown positive responses to anti-PD-1 therapy. Neoantigens are sequence-altered proteins re…
View article: Supplemental Figure 1a from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma
Supplemental Figure 1a from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma Open
Principal Component Analysis According to ADH1B genotype
View article: Supplemental Figure 1d from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma
Supplemental Figure 1d from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma Open
Principal Component Analysis According to HCC vs. non-HCC cases
View article: Supplemental Figures from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer
Supplemental Figures from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer Open
Supplementary Figures 1-5.
View article: Supplementary Data from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer
Supplementary Data from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer Open
Supplementary Materials and Tables
View article: Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy
Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Open
Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge r…
View article: Supplemental Figure 1b from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma
Supplemental Figure 1b from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma Open
Principal Component Analysis According to ALDH2 genotype
View article: Data from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer
Data from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer Open
Human leukocyte antigen (HLA) gene variation is associated with risk of cancers, particularly those with infectious etiology or hematopoietic origin, given its role in immune presentation. Previous studies focused primarily on HLA allele/h…
View article: Supplemental Figures from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer
Supplemental Figures from Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer Open
Supplementary Figures 1-5.
View article: Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy
Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Open
Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge r…
View article: Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy
Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Open
Figure S1. Hair cycles and disruption and restoration of differentiation in anagen HFs after IR. Figure S2. Comparison of apoptosis and DNA damage response of K5+ and K5negative cells in the hair matrix. Figure S3. Immunofluorescent compar…
View article: Data from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma
Data from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma Open
Background: The role of polymorphisms on ADH1B and ALDH2 in patients with chronic hepatitis B is unclear. This study aims to examine whether alcohol drinking mediates the association between two ADH1B and ALD…
View article: Data from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma
Data from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma Open
Background: The role of polymorphisms on ADH1B and ALDH2 in patients with chronic hepatitis B is unclear. This study aims to examine whether alcohol drinking mediates the association between two ADH1B and ALD…
View article: Supplemental Figure 1d from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma
Supplemental Figure 1d from Alcohol Drinking Mediates the Association between Polymorphisms of <i>ADH1B</i> and <i>ALDH2</i> and Hepatitis B–Related Hepatocellular Carcinoma Open
Principal Component Analysis According to HCC vs. non-HCC cases